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Cited by 164

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy

Open access
Rae, Caroline D., Williams, Stephen R.·2017·Analytical Biochemistry
DOI 10.1016/j.ab.2016.12.022
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Abstract

We review the transport, synthesis and catabolism of glutathione in the brain as well as its compartmentation and biochemistry in different brain cells. The major reactions involving glutathione are reviewed and the factors limiting its availability in brain cells are discussed. We also describe and critique current methods for measuring glutathione in the human brain using magnetic resonance spectroscopy, and review the literature on glutathione measurements in healthy brains and in neurological, psychiatric, neurodegenerative and neurodevelopmental conditions In summary: Healthy human brain glutathione concentration is ∼1-2 mM, but it varies by brain region, with evidence of gender differences and age effects; in neurological disease glutathione appears reduced in multiple sclerosis, motor neurone disease and epilepsy, while being increased in meningiomas; in psychiatric disease the picture is complex and confounded by methodological differences, regional effects, length of disease and drug-treatment. Both increases and decreases in glutathione have been reported in depression and schizophrenia. In Alzheimer's disease and mild cognitive impairment there is evidence for a decrease in glutathione compared to age-matched healthy controls. Improved methods to measure glutathione in vivo will provide better precision in glutathione determination and help resolve the complex biochemistry of this molecule in health and disease.

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Metadata

Authors
Rae, C. D., & Williams, S. R.
Venue
Analytical Biochemistry
Publisher
Elsevier BV
Published
2017-07
Volume
529
Pages
127-143
ISSN
0003-2697 (ISSN-L)
DOI
10.1016/j.ab.2016.12.022
OpenAlex
W2566293522
Cited by
164
References
13
FWCI
6.19
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy. https://app.cochat.ai/papers/10.1016/j.ab.2016.12.022
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Rae, C. D., & Williams, S. R. (2017). Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy. Analytical Biochemistry. https://doi.org/10.1016/j.ab.2016.12.022

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.