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The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Mitochondrial membrane potential

Open access
Zorova, Ljubava D., Popkov, Vasily A., Plotnikov, Egor Y., Silachev, Denis N., Pevzner, Irina B., Jankauskas, Stanislovas S., Babenko, Valentina A., Zorov, Savva D., Balakireva, Anastasia V., Juhaszova, Magdalena, Sollott, Steven J., Zorov, Dmitry B.·2018·Analytical Biochemistry
DOI 10.1016/j.ab.2017.07.009
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Abstract

The mitochondrial membrane potential (ΔΨm) generated by proton pumps (Complexes I, III and IV) is an essential component in the process of energy storage during oxidative phosphorylation. Together with the proton gradient (ΔpH), ΔΨm forms the transmembrane potential of hydrogen ions which is harnessed to make ATP. The levels of ΔΨm and ATP in the cell are kept relatively stable although there are limited fluctuations of both these factors that can occur reflecting normal physiological activity. However, sustained changes in both factors may be deleterious. A long-lasting drop or rise of ΔΨmvs normal levels may induce unwanted loss of cell viability and be a cause of various pathologies. Among other factors, ΔΨm plays a key role in mitochondrial homeostasis through selective elimination of dysfunctional mitochondria. It is also a driving force for transport of ions (other than H+) and proteins which are necessary for healthy mitochondrial functioning. We propose additional potential mechanisms for which ΔΨm is essential for maintenance of cellular health and viability and provide recommendations how to accurately measure ΔΨm in a cell and discuss potential sources of artifacts.

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Metadata

Authors
Zorova, L. D., Popkov, V. A., Plotnikov, E. Y., Silachev, D. N., Pevzner, I. B., Jankauskas, S. S., Babenko, V. A., Zorov, S. D., Balakireva, A. V., Juhaszova, M., Sollott, S. J., & Zorov, D. B.
Venue
Analytical Biochemistry
Publisher
Elsevier BV
Published
2018-07
Volume
552
Pages
50-59
ISSN
0003-2697 (ISSN-L)
DOI
10.1016/j.ab.2017.07.009
OpenAlex
W2735590725
Cited by
2,006
References
12
FWCI
30.18
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Mitochondrial membrane potential. https://app.cochat.ai/papers/10.1016/j.ab.2017.07.009
The paper
Zorova, L. D., Popkov, V. A., Plotnikov, E. Y., Silachev, D. N., Pevzner, I. B., Jankauskas, S. S., Babenko, V. A., Zorov, S. D., Balakireva, A. V., Juhaszova, M., Sollott, S. J., & Zorov, D. B. (2018). Mitochondrial membrane potential. Analytical Biochemistry. https://doi.org/10.1016/j.ab.2017.07.009

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.