Reactive Oxygen Species (Ros-Induced) Ros Release
Open accessAbstract
We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of tetramethylrhodamine derivatives, which also served to report the mitochondrial transmembrane potential, ΔΨ. This ROS accumulation reproducibly triggered abrupt (and sometimes reversible) mitochondrial depolarization. This phenomenon was ascribed to MPT induction because (a) bongkrekic acid prevented it and (b) mitochondria became permeable for calcein (∼620 daltons) concurrently with depolarization. These photodynamically produced “triggering” ROS caused the MPT induction, as the ROS scavenger Trolox prevented it. The time required for triggering ROS to induce the MPT was dependent on intrinsic cellular ROS-scavenging redox mechanisms, particularly glutathione. MPT induction caused by triggering ROS coincided with a burst of mitochondrial ROS generation, as measured by dichlorofluorescein fluorescence, which we have termed mitochondrial “ROS-induced ROS release” (RIRR). This MPT induction/RIRR phenomenon in cardiac myocytes often occurred synchronously and reversibly among long chains of adjacent mitochondria demonstrating apparent cooperativity. The observed link between MPT and RIRR could be a fundamental phenomenon in mitochondrial and cell biology.
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High levels of ROS may damage mitochondria, leading to opening of mitochondrial pores and loss of membrane polarization.
“High levels of ROS may damage mitochondria, leading to the opening of mitochondrial pores and allowing the influx of protons and ions, which leads to a loss of membrane polarization (13, 52).”
From Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence (2009) · cites this paper as [52]
An oxidant burst in one mitochondrion can spread oxidant production throughout the mitochondrial network via transient MPT pore formation, waves of reduction in mitochondrial potential, and propagation of oxidant bursts, at least in cardiomyocytes.
“An oxidant burst in one mitochondrion may also serve to spread oxidant production throughout the mitochondrial network in a manner that involves transient MPT pore formation, waves of reduction in mitochondrial potential, and propagation of oxidant bursts, at least in cardiomyocytes (48, 481).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [481]
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“…swelling and SOCS3 upregulation NMJ deterioration Bannow et al. (2022) the study also found that mitochondrial function within the muscle decreased during aging, as well as in response to altered neuronal redox status prior to NMJ deterioration or loss of muscle mass and force (Zorov et al., 2000).”
BackgroundJankauskas, S. S., Pevzner, I. B., Andrianova, N. V., Zorova, L. D., Popkov, V. A., Silachev, D. N., Kolosova, N. G., Plotnikov, E. Y., & Zorov, D. B. (2017) · Scientific Reports · doi:10.1038/srep44430 · Cited by 41 · see citing works
Self-citation
- Authors
- Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J.
- Affiliations
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2000-10-02
- Volume
- 192
- Issue
- 7
- Pages
- 1001-1014
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2193314
- OpenAlex
- W2135314348
- Cited by
- 1,412
- References
- 48
- Citations by year
- 2026: 34 · 2025: 40 · 2024: 62 · 2023: 71 · 2022: 69 · 2021: 82 · 2020: 71 · 2019: 56 · 2018: 67 · 2017: 70 · 2016: 78 · 2015: 65 · 2014: 68 · 2013: 67 · 2012: 70
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-38324, R01HL063744, HL52315, P50HL052315, HL 63744, R01HL038324)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- reactive oxygen species, mitochondrial permeability transition, cardiomyocytes, mitochondrial depolarization, mitochondrial membrane potential, bongkrekic acid, glutathione, mitochondrial ROS generation
- MeSH terms
- Animals, Calcium, Cells, Cultured, Fluorescent Dyes, Heart, Mitochondria, Heart, Myocardium, Oxidation-Reduction, Permeability, Proteins, Solubility, Sulfhydryl Compounds, Reactive Oxygen Species, Rats
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