The causes and functions of mitochondrial proton leak

Chapter 4 Preparation of Isolated Rat Liver Cells

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Cardiolipins and biomembrane function

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PROTEIN TURNOVER WITH SPECIAL REFERENCE TO MAN

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Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile

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Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the ‘top‐down’ approach of metabolic control theory

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The proton leak across the mitochondrial inner membrane

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Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate

Porter, R. K., & Brand, M. D. (1993) · Nature · doi:10.1038/362628a0 · Cited by 257 · see citing works

Significance of cation transport in control of energy metabolism and thermogenesis.

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CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS

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Effect of Funiculosin and Antimycin A on the Redox‐Driven H+‐Pumps in Mitochondria: on the Nature of ‘Leaks’

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Non-ohmic proton conductance of the mitochondrial inner membrane in hepatocytes.

Nobes, C. D., Brown, G. C., Olive, P. N., & Brand, M. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38245-6 · Cited by 191 · see citing works

Control of respiration and oxidative phosphorylation in isolated rat liver cells

Brown, G. C., Lakin‐Thomas, P. L., & Brand, M. D. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19234.x · Cited by 175 · see citing works

The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status

Harper, M., & Brand, M. D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82411-5 · Cited by 171 · see citing works

Altered relationship between protonmotive force and respiration rate in non‐phosphorylating liver mitochondria isolated from rats of different thyroid hormone status

Hafner, R. P., Nobes, C. D., McGown, A. D., & Brand, M. D. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14477.x · Cited by 151 · see citing works

Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes

Brand, M. D., Harper, M., & Taylor, H. C. (1993) · Biochemical Journal · doi:10.1042/bj2910739 · Cited by 126 · see citing works

The contribution of the leak of protons across the mitochondrial inner membrane to standard metabolic rate

Brand, M. D. (1990) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80131-6 · Cited by 115 · see citing works

The mechanism of the increase in mitochondrial proton permeability induced by thyroid hormones

Brand, M. D., Steverding, D., Kadenbach, B., Stevenson, P. M., & Hafner, R. P. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16984.x · Cited by 101 · see citing works

Experimental discrimination between proton leak and redox slip during mitochondrial electron transport

Brand, M. D., Chien, L., & Diolez, P. (1994) · Biochemical Journal · doi:10.1042/bj2970027 · Cited by 99 · see citing works

The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes.

Nobes, C. D., Hay, W. W., & Brand, M. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38246-8 · Cited by 80 · see citing works

On the nature of the mitochondrial proton leak

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Protonmotive functions of cytochrome c oxidase in reconstituted vesicles. Influence of turnover rate on ‘proton translocation’

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Variable stoichiometry of proton pumping by the mitochondrial respiratory chain

Murphy, M. P., & Brand, M. D. (1987) · Nature · doi:10.1038/329170a0 · Cited by 71 · see citing works

Effects of thyroid hormones on oxidative phosphorylation

Harper, M., Ballantyne, J. S., Leach, M. F., & Brand, M. D. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210785 · Cited by 63 · see citing works

Flux ratios and pump stoichiometries at sites II and III in liver mitochondria. Effect of slips and leaks.

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Hypothyroidism in rats decreases mitochondrial inner membrane cation permeability

Hafner, R. P., Leake, M. J., & Brand, M. D. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80455-7 · Cited by 46 · see citing works

Hypothyroidism in rats does not lower mitochondrial ADP/O and H+/O ratios

Hafner, R. P., & Brand, M. D. (1988) · Biochemical Journal · doi:10.1042/bj2500477 · Cited by 44 · see citing works

Characterisation of the control of respiration in potato tuber mitochondria using the top‐down approach of metabolic control analysis

Kesseler, A., Diolez, P., Brinkmann, K., & Brand, M. D. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17480.x · Cited by 39 · see citing works

Control of oxidative phosphorylation in liver mitochondria and hepatocytes

Brand, M. D., Chien, L., & Rolfe, D. F. S. (1993) · Biochemical Society Transactions · doi:10.1042/bst0210757 · Cited by 34 · see citing works

The proteoliposomal steady state. Effect of size, capacitance and membrane permeability on cytochrome-oxidase-induced ion gradients

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Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works

Energetics of bacterial growth: balance of anabolic and catabolic reactions

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Uncoupling to survive? The role of mitochondrial inefficiency in ageing

Brand, M. D. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00135-2 · Cited by 789 · see citing works

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J. (2005) · Biochemical Journal · doi:10.1042/bj20050890 · Cited by 410 · see citing works

The efficiency and plasticity of mitochondrial energy transduction.

Brand, M. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330897 · Cited by 406 · see citing works

Molecular mechanisms linking calorie restriction and longevity

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G., & Brand, M. D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01540-9 · Cited by 227 · see citing works

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function

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The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

Cadenas, S., Echtay, K. S., Harper, J. A., Jekabsons, M. B., Buckingham, J. A., Grau, E., Abuin, A., Chapman, H., Clapham, J. C., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109736200 · Cited by 199 · see citing works

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169 · see citing works

Mitochondrial proton leak and the uncoupling protein 1 homologues

Stuart, J. A., Cadenas, S., Jekabsons, M. B., Roussel, D., & Brand, M. D. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00243-7 · Cited by 169 · see citing works

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

Christoffersen, B. Ø., Sanchez‐Delgado, G., John, L. M., Ryan, D. H., Raun, K., & Ravussin, E. (2022) · Obesity · doi:10.1002/oby.23374 · Cited by 142 · see citing works

Exercise and mitochondrial dynamics: keeping in shape with ROS and AMPK

Trewin, A., Berry, B., & Wojtovich, A. (2018) · Antioxidants · doi:10.3390/antiox7010007 · Cited by 129 · see citing works

The efficiency of cellular energy transduction and its implications for obesity

Harper, M.-E., Green, K., & Brand, M. D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155357 · Cited by 121 · see citing works

Triiodothyronine‐mediated upregulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes

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Top-down control analysis of temperature effect on oxidative phosphorylation

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Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

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Mechanistic and methodological perspectives on the impact of intense interval training on post-exercise metabolism

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Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics

Yu, X. X., Barger, J. L., Boyer, B. B., Brand, M. D., Pan, G., & Adams, S. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e433 · Cited by 81 · see citing works

Diorcinol D Exerts Fungicidal Action against Candida albicans through Cytoplasm Membrane Destruction and ROS Accumulation

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Glucocorticoid and thyroid hormone receptors in mitochondria of animal cells

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The lifecycle of skeletal muscle mitochondria in obesity

Pileggi, C. A., Parmar, G., & Harper, M. (2021) · Obesity Reviews · doi:10.1111/obr.13164 · Cited by 61 · see citing works

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells

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Targeting skeletal muscle mitochondrial health in obesity

Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21 · see citing works

Substituted Hydrocarbons

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Electrochemical and spectroelectrochemical properties of thiadiazole substituted metallo-phthalocyanines

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Model-based leak localization in small water supply networks

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Procedure for the determination of redox potentials of chemically (and electrochemically) irreversible inorganic redox couples from spectroscopic data

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Redox Materials

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