Understanding peroxynitrite biochemistry and its potential for treating human diseases
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The fate of NO is dramatically changed in the presence of other free radicals such as superoxide.
“Biologically, this means that the fate of NO is dramatically changed in the presence of other free radicals such as superoxide (O2˙̄) (2, 20–22).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [22]
The best studied reaction of NO with other free radicals is the very rapid reaction of NO with superoxide to form peroxynitrite.
“The best studied of these reactions is the very rapid reaction of NO with superoxide to form peroxynitrite (2, 21, 22, 24).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [22]
Since the realization that peroxynitrite is produced in biological systems, it has been proposed to be a major mediator of the pathological effects associated with NO, particularly inflammation.
“Since the realization that peroxynitrite is produced in biological systems, it has been proposed to be a major mediator of the pathological effects associated with NO, particularly inflammation (22).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [22]
Peroxynitrite and reactive species derived from it are important in inflammatory responses and can modulate cell signaling, in part by promoting oxidation or nitration of biomolecules.
“Peroxynitrite and reactive species derived from it (e.g., nitrogen dioxide) are important in inflammatory responses [85] and can modulate cell signaling [87-90], in part by promoting the oxidation or nitration of a broad range of biomolecules [62].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [85]
The presence of free radicals such as superoxide changes the fate of NO: once reacted, it forms peroxynitrite and can no longer bind to ferrous heme.
“The presence of free radicals such as superoxide (O2.−) [82-85] changes the fate of NO: once reacted, it forms peroxynitrite [82, 84, 85] and can no longer bind to ferrous heme [86].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [85]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Self-citationNitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works
Self-citationRadí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,196 · see citing works
Self-citationPeroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,495 · see citing works
Self-citationPeroxynitrite formation from macrophage-derived nitric oxide
Ischiropoulos, H., Zhu, L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90433-w · Cited by 1,099 · see citing works
Self-citationBeckman, J. S., Carson, M. A., Smith, C. D. L., & Koppenol, W. H. (1993) · Nature · doi:10.1038/364584a0 · Cited by 876 · see citing works
Self-citationFormation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite
van der Vliet, A., Eiserich, J. P., Halliwell, B., & Cross, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7617 · Cited by 780 · see citing works
Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite
Beckman, J. S., Ischiropoulos, H., Zhu, L., van der Woerd, M., Smith, C. D. L., Chen, J., Harrison, J. G., Martin, J. C., & Tsai, M. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90432-v · Cited by 765 · see citing works
Self-citationEstévez, A. G., Crow, J. P., Sampson, J. B., Reiter, C., Zhuang, Y., Richardson, G. J., Tarpey, M. M., Barbeito, L., & Beckman, J. S. (1999) · Science · doi:10.1126/science.286.5449.2498 · Cited by 596 · see citing works
Self-citationCrow, J. P., Sampson, J. B., Zhuang, Y., Thompson, J. A., & Beckman, J. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051936.x · Cited by 487 · see citing works
Self-citationChemistry of Peroxynitrites as Compared to Peroxynitrates
Goldstein, S., Lind, J., & Merényi, G. (2005) · Chemical Reviews · doi:10.1021/cr0307087 · Cited by 411 · see citing works
Superoxide Reacts with Nitric Oxide to Nitrate Tyrosine at Physiological pH via Peroxynitrite
Reiter, C. D., Teng, R., & Beckman, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910433199 · Cited by 385 · see citing works
Self-citationTyrosine Modification by Reactive Nitrogen Species: A Closer Look
Vandervliet, A., Eiserich, J. P., O’Neill, C., Halliwell, B. B., & Cross, C. E. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1303 · Cited by 373 · see citing works
Hooper, D. C., Bagasra, O., Marini, J. C., Zborek, A., Ohnishi, S. T., Kean, R. B., Champion, J. M., Sarker, A. B., Bobroski, L. E., Farber, J. L., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2528 · Cited by 333 · see citing works
Hinson, J., Reid, A. B., McCullough, S. S., & James, L. P. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-200033494 · Cited by 306 · see citing works
Crow, J. P., Ye, Y. Z., Strong, M. J., KIRK, M. C., Barnes, S., & Beckman, J. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051945.x · Cited by 260 · see citing works
Self-citationHydroxyl Radical Formation during Peroxynitrous Acid Decomposition
Coddington, J. W., Hurst, J. K., & Lymar, S. V. (1999) · Journal of the American Chemical Society · doi:10.1021/ja982887t · Cited by 255 · see citing works
Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins
Ohshima, H., Friesen, M. D., Brouet, I., & Bartsch, H. (1990) · Food and Chemical Toxicology · doi:10.1016/0278-6915(90)90173-k · Cited by 250 · see citing works
Lancaster, J. R. (2006) · Chemical Research in Toxicology · doi:10.1021/tx060061w · Cited by 219 · see citing works
Hinson, J. A., Pike, S. L., Pumford, N. R., & Mayeux, P. R. (1998) · Chemical Research in Toxicology · doi:10.1021/tx9800349 · Cited by 218 · see citing works
On the pH-dependent yield of hydroxyl radical products from peroxynitrite
Crow, J. P., Spruell, C., Chen, J., Gunn, C., Ischiropoulos, H., Tsai, M. Y., Smith, C. D. L., Radí, R., Koppenol, W. H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90034-5 · Cited by 203 · see citing works
Self-citationWink, D. A., Cook, J. A., Kim, S. Y., Yoram Vodovotz, B., Pacelli, R., Krishna, M. C., Russo, A., Mitchell, J. B., Jourd’heuil, D., Miles, A. M., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11147 · Cited by 189 · see citing works
Cassina, P., Peluffo, H., Pehar, M., Palma, L. M., Ressia, A., Beckman, J. S., Estévez, Á. G., & Barbeito, L. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10107 · Cited by 184 · see citing works
Self-citationTyrosine Nitration by Simultaneous Generation of ⋅NO and O⨪2 under Physiological Conditions
Goldstein, S., Czapski, G., Lind, J., & Merényi, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3031 · Cited by 177 · see citing works
Quantitative neuropathological changes in presymptomatic Huntington's disease
Gómez‐Tortosa, E., MacDonald, M. E., Friend, J. C., Taylor, S. A., Weiler, L., Cupples, L. A., Srinidhi, J., Gusella, J. F., Bird, E. D., Vonsattel, J., et al. (2001) · Annals of Neurology · doi:10.1002/1531-8249(200101)49:1 · Cited by 170 · see citing works
Kean, R. B., Spitsin, S. V., Mikheeva, T., Scott, G. S., & Hooper, D. C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6511 · Cited by 157 · see citing works
Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALS
Roberts, B. R., Tainer, J. A., Getzoff, E. D., Malencik, D. A., Anderson, S. R., Bomben, V. C., Meyers, K. R., Karplus, P. A., & Beckman, J. S. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.07.043 · Cited by 152 · see citing works
Self-citationThe Chemistry of Peroxynitrite: Implications for Biological Activity
Goldstein, S., & Merényi, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)36004-2 · Cited by 145 · see citing works
Diet, Urate, and Parkinson's Disease Risk in Men
Gao, X., Chen, H., Choi, H. K., Curhan, G. C., Schwarzschild, M. A., & Ascherio, A. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm385 · Cited by 143 · see citing works
Estévez, Á. G., Spear, N., Manuel, S. M., Barbeito, L., Radí, R., & Beckman, J. S. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)63214-8 · Cited by 91 · see citing works
Self-citationThe role of uric acid in protection against peroxynitrite-mediated pathology
Scott, G. S., & Hooper, D. C. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1118 · Cited by 90 · see citing works
Plasma Urate and Progression of Mild Cognitive Impairment
Irizarry, M. C., Raman, R., Schwarzschild, M. A., et al. (2008) · Neurodegenerative Diseases · doi:10.1159/000170883 · Cited by 86 · see citing works
Hinson, J. A. (2000) · Toxicological Sciences · doi:10.1093/toxsci/53.2.467 · Cited by 76 · see citing works
Jourd’heuil, D., Miranda, K. M., Kim, S. M., Espey, M. G., Yoram Vodovotz, B., Laroux, S., Mai, C. T., Miles, A. M., Grisham, M. B., & Wink, D. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1143 · Cited by 74 · see citing works
Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration
Teng, R., Ye, Y.-Z. U., Parks, D. A., et al. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01020-1 · Cited by 68 · see citing works
Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase
Smith, C. D. L., Carson, M., van der Woerd, M., Chen, J., Ischiropoulos, H., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90286-6 · Cited by 67 · see citing works
Self-citationYe, Y., Quijano, C., Robinson, K. M., Ricart, K. C., Strayer, A. L., Garner, M. A., Shacka, J. J., KIRK, M. C., Barnes, S., Accavitti-Loper, M. A., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610800200 · Cited by 58 · see citing works
Self-citationRole of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver
Zhu, J., Zhang, X., Roneker, C. A., McClung, J. P., Zhang, S., Thannhauser, T. W., Ripoll, D. R., Sun, Q., & Lei, X. G. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.018 · Cited by 41 · see citing works
Zhu, J., & Lei, X. G. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100508 · Cited by 21 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [12]Jian-Hong Z Zhang X Roneker CA McClung JP Zhang S Thannhauser TW Ripoll DR Sun Q Lei XG 2008 Free Radic Biol Med 45 5 611 618 18573333 PMC3078524
- [37]Van der Vliet A Eiserich JP O’Neill CA Halliwell B Cross CE 1995 Arch Biochem Biophys 319 2 341 349 7786014
Cited by
Sorted by citations
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“nitrogen dioxide) are important in inflammatory responses [85] and can modulate cell signaling [87–90], in part by promoting the”
BackgroundDietary Nitrate, Nitric Oxide, and Cardiovascular Health
Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141 · see citing works
Endothelial nitric oxide synthase: A potential therapeutic target for cerebrovascular diseases
Zhu, J., Song, W., Li, L., & Fan, X. (2016) · Molecular Brain · doi:10.1186/s13041-016-0211-9 · Cited by 96 · see citing works
Surmeli, N. B., Litterman, N. K., Miller, A.-F., & Groves, J. T. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105684w · Cited by 94 · see citing works
- Authors
- Beckman, J. S.
- Affiliations
- Oregon State University (US)
- Corresponding author
- Beckman, Joseph S.
- ORCID
- Beckman, Joseph S.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 484
- Issue
- 2
- Pages
- 114-116
- ISSN
- 0003-9861 (ISSN-L)
- PMC
- PMC2709800
- OpenAlex
- W1987922251
- Cited by
- 56
- References
- 39
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS058628)
- National Institute of Environmental Health Sciences (P01ES000040, P30ES000210)
- National Center for Complementary and Integrative Health (P01AT002034)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- peroxynitrite, tyrosine nitration, lipid peroxidation, scholarly publishing, citation impact
- MeSH terms
- Bacteria, Biochemistry, Disease, Humans, Nitrates, Nitrophenols, Superoxides, Superoxide Dismutase, Tyrosine, Macrophages, Alveolar, Cell Death, Peroxynitrous Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
