Dietary Nitrate, Nitric Oxide, and Cardiovascular Health

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study

Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007 · see citing works

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure

Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981 · see citing works

Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond

Lloyd-Jones, D. M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L. J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., Tomaselli, G. F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192703 · Cited by 4,750 · see citing works

Vascular endothelial cells synthesize nitric oxide from L-arginine

Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,745 · see citing works

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., Cooper, C. E., & Knowles, R. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570593 · Cited by 4,106 · see citing works

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works

Platelet Activation and Atherothrombosis

Davì, G., & Patrono, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071014 · Cited by 2,135 · see citing works

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works

The clinical implications of endothelial dysfunction

Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 4× · see citing works

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

Vallance, P., Collier, J., & Moncada, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91013-1 · Cited by 1,590 · see citing works

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,586 · see citing works

Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population

Willum Hansen, T., Staessen, J. A., Torp-Pedersen, C., Rasmussen, S., Thijs, L., Ibsen, H., & Jeppesen, J. (2006) · Circulation · doi:10.1161/circulationaha.105.579342 · Cited by 1,515 · see citing works

Optimal Diets for Prevention of Coronary Heart Disease

Hu, F. B. (2002) · JAMA · doi:10.1001/jama.288.20.2569 · Cited by 1,503 · see citing works

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437 · see citing works

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

Jaffrey, S. R., Erdjument‐Bromage, H., Ferris, C. D., Tempst, P., & Snyder, S. H. (2001) · Nature Cell Biology · doi:10.1038/35055104 · Cited by 1,402 · see citing works

The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease

Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396 · see citing works

Fruit and vegetables, and cardiovascular disease: A review

Ness, A. R., & Powles, J. W. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.1.1 · Cited by 1,368 · see citing works

Fruit and vegetable intake and risk of major chronic disease

Hung, H.-C., Joshipura, K. J., Jiang, R., Hu, F. B., Hunter, D., Smith-Warner, S. A., Colditz, G. A., Rosner, B., Spiegelman, D., & Willett, W. C. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh296 · Cited by 1,327 · see citing works

Mechanical Factors in Arterial Aging

O’Rourke, M. F., & Hashimoto, J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.12.050 · Cited by 1,245 · see citing works

Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus: A Systematic Review and Meta-Analysis

Micha, R., Wallace, S. K., & Mozaffarian, D. (2010) · Circulation · doi:10.1161/circulationaha.109.924977 · Cited by 1,244 · see citing works

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238 · see citing works

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

Radomski, M. W., Palmer, R. M., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5193 · Cited by 1,208 · see citing works

Endothelial Dysfunction

Endemann, D. H., & Schiffrin, E. L. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000132474.50966.da · Cited by 1,198 · see citing works

Physiology of Nitric Oxide in Skeletal Muscle

Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080 · see citing works

Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke

Joshipura, K. J. (1999) · JAMA · doi:10.1001/jama.282.13.1233 · Cited by 1,078 · see citing works

Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078 · see citing works

Food sources of nitrates and nitrites: The physiologic context for potential health benefits

Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069 · see citing works

Nitrate in vegetables: toxicity, content, intake and EC regulation

Santamaria, P. (2006) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2351 · Cited by 1,064 · see citing works

Methods to detect nitric oxide and its metabolites in biological samples

Bryan, N. S., & Grisham, M. B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.026 · Cited by 1,005 · see citing works

Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors

Cornelissen, V. A., & Fagard, R. H. (2005) · Hypertension · doi:10.1161/01.hyp.0000184225.05629.51 · Cited by 1,005 · see citing works

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

Lamas, S., Marsden, P. A., Li, G. K., Tempst, P., & Michel, T. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6348 · Cited by 982 · see citing works

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

Ignarro, L. J. (1989) · Circulation Research · doi:10.1161/01.res.65.1.1 · Cited by 964 · see citing works

Regular Physical Activity Improves Endothelial Function in Patients With Coronary Artery Disease by Increasing Phosphorylation of Endothelial Nitric Oxide Synthase

Hambrecht, R., Adams, V., Erbs, S., Linke, A. H.-P., Kränkel, N., Shu, Y., Baither, Y., Gielen, S., Thiele, H., Gummert, J. F., et al. (2003) · Circulation · doi:10.1161/01.cir.0000074229.93804.5c · Cited by 941 · see citing works

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J., & Hintze, T. H. (1994) · Circulation Research · doi:10.1161/01.res.74.2.349 · Cited by 934 · see citing works

Nitric oxide synthase: Aspects concerning structure and catalysis

Marletta, M. A. (1994) · Cell · doi:10.1016/0092-8674(94)90268-2 · Cited by 862 · see citing works

Endogenous nitric oxide synthesis: Biological functions and pathophysiology

Bredt, D. S. (1999) · Free Radical Research · doi:10.1080/10715769900301161 · Cited by 796 · see citing works

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works

Enzyme-independent formation of nitric oxide in biological tissues

Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788 · see citing works

Blue babies and nitrate-contaminated well water

Knobeloch, L., Salna, B., Hogan, A., Postle, J., & Anderson, H. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108675 · Cited by 775 · see citing works

The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O ₂

Thomas, D. D., Liu, X., Kantrow, S. P., & Lancaster, J. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.355 · Cited by 760 · see citing works

Dietary nitrate supplementation reduces the O ₂ cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans

Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works

Aspirin

Awtry, E. H., & Loscalzo, J. (2000) · Circulation · doi:10.1161/01.cir.101.10.1206 · Cited by 691 · see citing works

Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans

Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · see citing works

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · cited 2× · see citing works

Nitric oxide metabolism and breakdown

Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673 · see citing works

Stomach NO synthesis

Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665 · see citing works

Intragastric nitric oxide production in humans: measurements in expelled air.

Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661 · see citing works

Inorganic nitrate is a possible source for systemic generation of nitric oxide

Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657 · see citing works

Effects of dietary nitrate on oxygen cost during exercise

Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO

Kapil, V., Milsom, A. B., Okorie, M., Maleki-Toyserkani, S., Akram, F., Rehman, F., Arghandawi, S., Pearl, V., Benjamin, N., Loukogeorgakis, S., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153536 · Cited by 621 · see citing works

CYANOSIS IN INFANTS CAUSED BY NITRATES IN WELL WATER

Comly, H. H. (1945) · JAMA · doi:10.1001/jama.1945.02860360014004 · Cited by 621 · see citing works

Nitrate and nitrite in biology, nutrition and therapeutics

Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.260 · Cited by 617 · see citing works

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

Loscalzo, J. (2001) · Circulation Research · doi:10.1161/hh0801.089861 · Cited by 612 · see citing works

The emerging biology of the nitrite anion

Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609 · see citing works

Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage

Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 2× · see citing works

Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans

Bailey, S. J., Fulford, J., Vanhatalo, A., Winyard, P. G., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Benjamin, N., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2010 · Cited by 607 · see citing works

Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works

Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds

Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works

Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries.

Benetos, A., Laurent, S., Hoeks, A. P. G., Boutouyrie, P., & Safar, M. E. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.1.90 · Cited by 587 · see citing works

Effects of Dietary Nitrate on Blood Pressure in Healthy Volunteers

Larsen, F. J., Ekblom, B., Sahlin, K., Lundberg, J. O., & Weitzberg, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmc062800 · Cited by 587 · see citing works

The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash

Govoni, M., Jansson, E. Å., Weitzberg, E., & Lundberg, J. O. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.003 · Cited by 585 · see citing works

Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women

Modena, M. G., Bonetti, L., Coppi, F., Bursi, F., & Rossi, R. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01976-9 · Cited by 573 · see citing works

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works

Quantitation of nitrate and nitrite in extracellular fluids

Grisham, M. B., Johnson, G. G., & Lancaster, J. R. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68026-4 · Cited by 542 · see citing works

Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise

Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Pavey, T. G., Wilkerson, D. P., Benjamin, N., Winyard, P. G., & Jones, A. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2010 · Cited by 529 · see citing works

Mediterranean diet and public health: personal reflections

Keys, A. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1321s · Cited by 528 · see citing works

Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues

Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518 · see citing works

Diffusion-limited reaction of free nitric oxide with erythrocytes

Liu, X., Miller, M. J. S., Joshi, M. S., Sadowska-Krowicka, H., Clark, D. A., & Lancaster, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18709 · Cited by 512 · see citing works

Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease

Neunteufl, T., Katzenschlager, R., Hassan, A. H. M., Klaar, U., Schwarzacher, S. P., Glogar, D., Bauer, P., & Weidinger, F. F. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06018-2 · Cited by 510 · see citing works

Nitric Oxide Regulates Local Arterial Distensibility In Vivo

Wilkinson, I. B., Qasem, A., McEniery, C. M., Webb, D. J., Avolio, A. P., & Cockcroft, J. R. (2002) · Circulation · doi:10.1161/hc0202.101970 · Cited by 502 · see citing works

Relevance of nitrosamines to human cancer

Bartsch, H., & Montesano, R. (1984) · Carcinogenesis · doi:10.1093/carcin/5.11.1381 · Cited by 495 · see citing works

Absence of Age-Related Increase in Central Arterial Stiffness in Physically Active Women

Tanaka, H., DeSouza, C. A., & Seals, D. R. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.127 · Cited by 487 · see citing works

The Molecule of the Year

Guyer, R. L., & Koshland, D. E. (1989) · Science · doi:10.1126/science.2688087 · Cited by 482 · see citing works

Dietary intake of fruits and vegetables and risk of cardiovascular disease

Bazzano, L. A., Serdula, M. K., & Liu, S. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0040-z · Cited by 472 · see citing works

Endothelial Dysfunction The First Step Toward Coronary Arteriosclerosis

Vanhoutte, P. M. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1169 · Cited by 467 · see citing works

Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia

Wilkinson, I. B., Prasad, K., Hall, I. R., Thomas, A., MacCallum, H., Webb, D. J., Frenneaux, M. P., & Cockcroft, J. R. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01723-0 · Cited by 448 · see citing works

Role of circulating nitrite and <i>S</i> -nitrosohemoglobin in the regulation of regional blood flow in humans

Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441 · see citing works

Effect of Smoking on Arterial Stiffness and Pulse Pressure Amplification

Mahmud, A., & Feely, J. (2003) · Hypertension · doi:10.1161/01.hyp.0000047464.66901.60 · Cited by 437 · see citing works

The Molecule of the Year

Koshland, D. E. (1992) · Science · doi:10.1126/science.1470903 · Cited by 436 · see citing works

Autoxidation kinetics of aqueous nitric oxide

Ford, P. C., Wink, D. A., & Stanbury, D. M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81748-o · Cited by 419 · see citing works

Physiological role for nitrate-reducing oral bacteria in blood pressure control

Kapil, V., Haydar, S. M. A., Pearl, V., Lundberg, J. O., Weitzberg, E., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.013 · Cited by 413 · see citing works

Vascular Consequences of Endothelial Nitric Oxide Synthase Uncoupling for the Activity and Expression of the Soluble Guanylyl Cyclase and the cGMP-Dependent Protein Kinase

Münzel, T. F., Daiber, A., Ullrich, V., & Mülsch, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000168896.64927.bb · Cited by 409 · see citing works

Dietary nitrate supplementation reduces the O₂cost of walking and running: a placebo-controlled study

Lansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Gilchrist, M., Benjamin, N., & Jones, A. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01070.2010 · Cited by 404 · see citing works

Cellular targets and mechanisms of nitros(yl)ation: An insight into their nature and kinetics <i>in vivo</i>

Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400 · see citing works

Endothelial function and nitric oxide: clinical relevance

Vallance, P. J., & Chan, N. N. (2001) · Heart · doi:10.1136/heart.85.3.342 · Cited by 389 · see citing works

Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans

Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., Balzer, J., Zotz, R. B., Scharf, R. E., Willers, R., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.025 · Cited by 388 · see citing works

Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance

LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works

The effect of nitrate intake on nitrite formation in human saliva

Tannenbaum, S. R., Weisman, M., & Fett, D. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80006-5 · Cited by 381 · see citing works

Nitrate, nitrite and N-nitroso compounds

Gangolli, S. D., van den Brandt, P. A., Feron, V. J., Janzowsky, C., Koeman, J. H., Speijers, G. J. A., Spiegelhalder, B., Walker, R., & Wishnok, J. S. (1994) · European Journal of Pharmacology: Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(94)90022-1 · Cited by 380 · see citing works

Fruits and vegetables in the prevention of cancer and cardiovascular disease

van't Veer, P., Jansen, M. C., Klerk, M., & Kok, F. J. (2000) · Public Health Nutrition · doi:10.1017/s1368980000000136 · Cited by 362 · see citing works

Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis

Shiva, S., Wang, X., Ringwood, L. A., Xu, X., Yuditskaya, S., Annavajjhala, V., Miyajima, H., Hogg, N., Harris, Z. L., & Gladwin, M. T. (2006) · Nature Chemical Biology · doi:10.1038/nchembio813 · Cited by 359 · see citing works

A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis

Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356 · see citing works

Roles of dietary inorganic nitrate in cardiovascular health and disease

Lundberg, J. O., Carlström, M., Larsen, F. J., & Weitzberg, E. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq325 · Cited by 355 · see citing works

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347 · see citing works

Nitrite reductase activity is a novel function of mammalian mitochondria

Kozlov, A. V., Staniek, K., & Nohl, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00788-7 · Cited by 342 · cited 2× · see citing works

NO Generation From Nitrite and Its Role in Vascular Control

Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works

Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation

Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334 · see citing works

Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise

Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.006 · Cited by 320 · see citing works

Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease

Kenjale, A. A., Ham, K. L., Stabler, T., Robbins, J. L., Johnson, J. L., VanBruggen, M., Privette, G., Yim, E., Kraus, W. E., & Allen, J. D. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00071.2011 · Cited by 316 · see citing works

BLOOD-PRESSURE-LOWERING EFFECT OF A VEGETARIAN DIET: CONTROLLED TRIAL IN NORMOTENSIVE SUBJECTS

ROUSE, I. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91557-x · Cited by 314 · see citing works

When Does Nitrate Become a Risk for Humans?

Powlson, D. S., Addiscott, T. M., Benjamin, N., Cassman, K. G., de Kok, T. M., van Grinsven, H., L'hirondel, J., Avery, A. A., & van Kessel, C. (2008) · Journal of Environmental Quality · doi:10.2134/jeq2007.0177 · Cited by 313 · see citing works

What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology

Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works

Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia.

Hull, S. S., Vanoli, E., Adamson, P. B., Verrier, R. L., Foreman, R. D., & Schwartz, P. J. (1994) · Circulation · doi:10.1161/01.cir.89.2.548 · Cited by 299 · see citing works

Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease-Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112761 · Cited by 298 · see citing works

Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial

Bondonno, C. P., Yang, X., Croft, K. D., Considine, M. J., Ward, N. C., Rich, L., Puddey, I. B., Swinny, E., Mubarak, A., & Hodgson, J. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.028 · Cited by 292 · see citing works

Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery

Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease‐Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12761 · Cited by 289 · see citing works

Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood

Li, H., Cui, H., Kundu, T. K., Alzawahra, W., & Zweier, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801785200 · Cited by 269 · see citing works

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

Gilchrist, M., Winyard, P. G., Aizawa, K., Anning, C., Shore, A., & Benjamin, N. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.024 · Cited by 261 · see citing works

Interactions Between Nitric Oxide and Lipid Oxidation Pathways: Implications for Vascular Disease

O’Donnell, V. B., & Freeman, B. A. (2001) · Circulation Research · doi:10.1161/01.res.88.1.12 · Cited by 257 · see citing works

Early Intravenous Infusion of Sodium Nitrite Protects Brain Against In Vivo Ischemia-Reperfusion Injury

Jung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253 · see citing works

Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice

Liu, V. W. T., & Huang, P. L. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.024 · Cited by 252 · see citing works

Nitrite in saliva increases gastric mucosal blood flow and mucus thickness

Björne, H., Petersson, J., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19019 · Cited by 246 · see citing works

Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense

Dykhuizen, R. S., Frazer, R., Duncan, C., Smith, C. C., Golden, M., Benjamin, N., & Leifert, C. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.6.1422 · Cited by 239 · see citing works

Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

Petersson, J., Carlström, M., Schreiber, O., Phillipson, M., Christoffersson, G., Jägare, A., Roos, S., Jansson, E. Å., Persson, A. E. G., Lundberg, J. O., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.011 · Cited by 235 · see citing works

Effects of short-term dietary nitrate supplementation on blood pressure, O₂uptake kinetics, and muscle and cognitive function in older adults

Kelly, J., Fulford, J., Vanhatalo, A., Blackwell, J. R., French, O., Bailey, S. J., Gilchrist, M., Winyard, P. G., & Jones, A. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00406.2012 · Cited by 232 · see citing works

Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence

MacArthur, P. H., Shiva, S., & Gladwin, M. T. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.12.012 · Cited by 229 · see citing works

Simultaneous Derivatization and Quantification of the Nitric Oxide Metabolites Nitrite and Nitrate in Biological Fluids by Gas Chromatography/Mass Spectrometry

Tsikas, D. (2000) · Analytical Chemistry · doi:10.1021/ac9913255 · Cited by 228 · see citing works

Vascular nitric oxide: formation and function

Loscalzo, J., & Jin (2010) · Journal of Blood Medicine · doi:10.2147/jbm.s7000 · Cited by 227 · see citing works

Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds.

Fox-Robichaud, A., Payne, D., Hasan, S. U., Ostrovsky, L., Fairhead, T., Reinhardt, P., & Kubes, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2736 · Cited by 227 · see citing works

Survey of Literature Relating to Infant Methemoglobinemia Due to Nitrate-Contaminated Water

Walton, G. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.8_pt_1.986 · Cited by 226 · see citing works

Nitrite-Derived Nitric Oxide Protects the Rat Kidney against Ischemia/Reperfusion Injury In Vivo: Role for Xanthine Oxidoreductase

Tripatara, P., Patel, N. S. A., Webb, A., Rathod, K., Lecomte, F. M. J., Mazzon, E., Cuzzocrea, S., Yaqoob, M. M., Ahluwalia, A., & Thiemermann, C. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050450 · Cited by 226 · see citing works

The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort

Shimbo, D., Grahame-Clarke, C., Miyake, Y., Rodriguez, C., Sciacca, R., Di Tullio, M., Boden-Albala, B., Sacco, R., & Homma, S. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.005 · Cited by 219 · see citing works

Infantile methemoglobinemia: Reexamining the role of drinking water nitrates

Avery, A. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107583 · Cited by 218 · see citing works

Tissue Processing of Nitrite in Hypoxia

Feelisch, M., Fernandez, B. O., Bryan, N. S., Garcia-Saura, M. F., Bauer, S., Whitlock, D. R., Ford, P. C., Janero, D. R., Rodriguez, J., & Ashrafian, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806654200 · Cited by 218 · see citing works

Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation

Aamand, R., Dalsgaard, T., Jensen, F. B., Simonsen, U., Roepstorff, A., & Fago, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2009 · Cited by 213 · see citing works

Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects

Hobbs, D. A., Kaffa, N., George, T. W., Methven, L., & Lovegrove, J. A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000190 · Cited by 194 · see citing works

Is the Association Between Flow-Mediated Dilation and Cardiovascular Risk Limited to Low-Risk Populations?

Witte, D. R., Westerink, J., de Koning, E. J. P., van der Graaf, Y., Grobbee, D. E., & Bots, M. L. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.073 · Cited by 191 · see citing works

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

Kumar, D., Branch, B. G., Pattillo, C. B., Hood, J., Thoma, S., Simpson, S., Illum, S., Arora, N., Chidlow, J. H., Langston, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711480105 · Cited by 187 · see citing works

Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers

Sobko, T., Marcus, C., Govoni, M., & Kamiya, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.007 · Cited by 185 · see citing works

Cardioprotective effects of vegetables: is nitrate the answer?

Lundberg, J. O., Feelisch, M., Björne, H., Jansson, E. Å., & Weitzberg, E. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.013 · Cited by 185 · see citing works

Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets

Alheid, U., Frölich, J. C., & Förstermann, U. (1987) · Thrombosis Research · doi:10.1016/0049-3848(87)90361-6 · Cited by 184 · see citing works

Direct and indirect effects of nitric oxide in chemical reactions relevant to biology

Wink, D. A., Grisham, M. B., Mitchell, J. B., & Ford, P. C. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68006-9 · Cited by 182 · see citing works

Plasma Nitrosothiols Contribute to the Systemic Vasodilator Effects of Intravenously Applied NO: Experimental and Clinical Study on the Fate of NO in Human Blood

Rassaf, T., Kleinbongard, P., Preik, M., Dejam, A., Gharini, P., Lauer, T., Erckenbrecht, J., Duschin, A., Schulz, R., Heusch, G., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000035038.41739.cb · Cited by 178 · see citing works

The oral bioavailability of nitrate from nitrate-rich vegetables in humans

van Velzen, A. G., Sips, A. J. A. M., Schothorst, R. C., Lambers, A. C., & Meulenbelt, J. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.07.019 · Cited by 172 · see citing works

Dietary nitrate increases gastric mucosal blood flow and mucosal defense

Petersson, J., Phillipson, M., Jansson, E. Å., Patzak, A., Lundberg, J. O., & Holm, L. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2006 · Cited by 161 · see citing works

Nitric oxide synthase reduces nitrite to NO under anoxia

Vanin, A. F., Bevers, L. M., Slama-Schwok, A., & van Faassen, E. E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6374-2 · Cited by 151 · see citing works

Nitric oxide signaling specificity — the heart of the problem

Bredt, D. S. (2002) · Journal of Cell Science · doi:10.1242/jcs.00183 · Cited by 147 · see citing works

Effects of Inhibition of Basal Nitric Oxide Synthesis on Carotid-Femoral Pulse Wave Velocity and Augmentation Index in Humans

Stewart, A. D., Millasseau, S., Kearney, M. T., Ritter, J. M., & Chowienczyk, P. (2003) · Hypertension · doi:10.1161/01.hyp.0000092882.65699.19 · Cited by 147 · see citing works

Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions

Petersen, M. G., Dewilde, S., & Fago, A. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.05.008 · Cited by 144 · see citing works

Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and KATP channels

Baker, J. E., Su, J., Fu, X., Hsu, A., Gross, G. J., Tweddell, J. S., & Hogg, N. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.057 · Cited by 137 · see citing works

Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function

Green, D. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00601.2005 · Cited by 129 · see citing works

Sir Joseph Barcroft C.B.E., M.A., D.Sc., Hon. M.D., Hon. F.R.C.O.G., F.R.S.

Harris, L. J. (1947) · British Journal Of Nutrition · doi:10.1079/bjn19470003 · Cited by 125 · see citing works

Methemoglobinemia in young infants

Cornblath, M., & Hartmann, A. F. (1948) · The Journal of Pediatrics · doi:10.1016/s0022-3476(48)80200-3 · Cited by 124 · see citing works

Detection of S-nitrosothiols in biological fluids: A comparison among the most widely applied methodologies

Giustarini, D., Milzani, A., Dalle‐Donne, I., & Rossi, R. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.09.031 · Cited by 123 · see citing works

Nitric oxide increases oxidative phosphorylation efficiency

Clerc, P., Rigoulet, M., Leverve, X. M., & Fontaine, E. M. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9074-1 · Cited by 122 · see citing works

S-Nitrosothiol measurements in biological systems

Gow, A. J., Doctor, A., Mannick, J. B., & Gaston, B. M. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.01.052 · Cited by 122 · see citing works

Nitric oxide synthase-derived plasma nitrite predicts exercise capacity

Rassaf, T., Lauer, T., Heiss, C., Balzer, J., Mangold, S., Leyendecker, T., Rottler, J., Drexhage, C., Meyer, C., & Kelm, M. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.035758 · Cited by 122 · see citing works

Nitrate and nitrite in vegetables on the Danish market: content and intake

Petersen, A., & Stoltze, S. (1999) · Food Additives &amp; Contaminants · doi:10.1080/026520399283957 · Cited by 120 · see citing works

Basal NO Locally Modulates Human Iliac Artery Function In Vivo

Schmitt, M., Avolio, A. P., Qasem, A., McEniery, C. M., Butlin, M., Wilkinson, I. B., & Cockcroft, J. R. (2005) · Hypertension · doi:10.1161/01.hyp.0000164581.39811.bd · Cited by 119 · see citing works

Dietary exposures to nitrate in the UK

Ysart, G., Miller, P., Barrett, G., Farrington, D., Lawrance, P., & Harrison, N. (1999) · Food Additives and Contaminants · doi:10.1080/026520399283669 · Cited by 117 · see citing works

Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers

Bahra, M., Kapil, V., Pearl, V., Ghosh, S., & Ahluwalia, A. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.01.004 · Cited by 116 · see citing works

Promoting Global Cardiovascular Health

Fuster, V., Kelly, B. B., & Vedanthan, R. (2011) · Circulation · doi:10.1161/circulationaha.110.009522 · Cited by 114 · see citing works

Inorganic nitrate and nitrite and control of blood pressure

Gilchrist, M., Shore, A. C., & Benjamin, N. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq309 · Cited by 110 · see citing works

Dietary nitrate supplementation improves revascularization in chronic ischemia

Hendgen-Cotta, U. B., Luedike, P., Totzeck, M., Kropp, M., Schicho, A., Stock, P., Rammos, C., Niessen, M., Heiss, C., Lundberg, J. O., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.112912 · Cited by 110 · see citing works

Dietary exposure models for nitrates and nitrites

Pennington, J. A. T. (1998) · Food Control · doi:10.1016/s0956-7135(98)00019-x · Cited by 108 · see citing works

Are nitrate concentrations in leafy vegetables within safe limits

Anjana, A., Umar, S., Iqbal, M. M., & Abrol, Y. P. (2007) · Cited by 105 · see citing works

Nitrate, agriculture and the environment

Addiscott, T. M. (2005) · CABI Publishing eBooks · doi:10.1079/9780851999135.0000 · Cited by 101 · see citing works

The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans

Richardson, G., Hicks, S. L., O'Byrne, S., Frost, M. T., Moore, K., Benjamin, N., & McKnight, G. M. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00010-1 · Cited by 101 · see citing works

Assessment of nitric oxide signals by triiodide chemiluminescence

Hausladen, A., Rafikov, R., Angelo, M., Singel, D. J., Nudler, E., & Stamler, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611191104 · Cited by 99 · see citing works

Inorganic nitrate and the cardiovascular system

Kapil, V., Webb, A. J., & Ahluwalia, A. (2010) · Heart · doi:10.1136/hrt.2009.180372 · Cited by 90 · see citing works

Untitled work

(2005) · PubMed · Cited by 88 · see citing works

Prevention of ischemia-reperfusion lung injury by inhaled nitric oxide in neonatal piglets

Barbotin-Larrieu, F., Mazmanian, M. G., Baudet, B., Détruit, H., Chapelier, A. R., Libert, J., Dartevelle, P., & Hervé, P. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.3.782 · Cited by 86 · see citing works

Human xanthine oxidase converts nitrite ions into nitric oxide (NO)

Zhang, Z., Naughton, D. P., Blake, D. R., Benjamin, N., Stevens, C. R., Winyard, P. G., Symons, M. C. R., & Harrison, R. (1997) · Biochemical Society Transactions · doi:10.1042/bst025524s · Cited by 85 · see citing works

Measurement of Nitric Oxide Levels in the Red Cell

Wang, X., Bryan, N. S., MacArthur, P. H., Rodriguez, J., Gladwin, M. T., & Feelisch, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603953200 · Cited by 79 · see citing works

Nitrite Promotes Lymphoma Incidence in Rats

Newberne, P. M. (1979) · Science · doi:10.1126/science.451551 · Cited by 78 · see citing works

Dietary inorganic nitrate mobilizes circulating angiogenic cells

Heiß, C., Meyer, C. G., Totzeck, M., Hendgen-Cotta, U. B., Heinen, Y., Luedike, P., Keymel, S., Ayoub, N., Lundberg, J. O., Weitzberg, E., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.051 · Cited by 78 · see citing works

Detection of Human Red Blood Cell-bound Nitric Oxide

Rogers, S. C., Khalatbari, A., Gapper, P. W., Frenneaux, M. P., & James, P. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501179200 · Cited by 77 · see citing works

Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine

Troncy, É., Francoeur, M., Salazkin, I., Yang, F., Charbonneau, M., Leclerc, G., Vinay, P., & Blaise, G. A. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/79.5.631 · Cited by 76 · see citing works

Effects of sodium nitrite on ischemia–reperfusion injury in the rat kidney

Basireddy, M., Isbell, T. S., Teng, X., Patel, R. P., & Agarwal, A. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00334.2005 · Cited by 72 · see citing works

Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver

Kozlov, A. V., Dietrich, B., & Nohl, H. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705323 · Cited by 69 · see citing works

Toxicology: Nitrosamines and human cancer: proof of an association?

Craddock, V. M. (1983) · Nature · doi:10.1038/306638a0 · Cited by 67 · see citing works

N-Nitrosamine Generation From Ingested Nitrate Via Nitric Oxide in Subjects With and Without Gastroesophageal Reflux

Winter, J. W., Paterson, S., Scobie, G., Wirz, A., Preston, T., & McColl, K. E. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.047 · Cited by 59 · see citing works

Understanding peroxynitrite biochemistry and its potential for treating human diseases

Beckman, J. S. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.03.013 · Cited by 56 · see citing works

Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation

Takahashi, Y. K., Kobayashi, H., Tanaka, N., Sato, T., Takizawa, N., & Tomita, T. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.1.h349 · Cited by 50 · see citing works

An improved mass spectrometry-based measurement of NO metabolites in biological fluids

Yang, X., Bondonno, C. P., Indrawan, A. P., Hodgson, J. M., & Croft, K. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.12.002 · Cited by 46 · see citing works

Chloride Bound to Oxidized Cytochrome c Oxidase Controls the Reaction with Nitric Oxide

Giuffrè, A., Stubauer, G., Brunori, M., Sarti, P., Torres, J., & Wilson, M. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32475 · Cited by 46 · see citing works

Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry

Rocks, S. A., Davies, C. A., Hicks, S. L., Webb, A. J., Klocke, R., Timmins, G. S., Johnston, A. E., Jawad, A. S. M., Blake, D. R., Benjamin, N., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.05.007 · Cited by 40 · see citing works

Control of Plasma Nitric Oxide Bioactivity by Perfluorocarbons

Rafikova, O., Sokolova, E., Rafikov, R., & Nudler, E. (2004) · Circulation · doi:10.1161/01.cir.0000148782.37563.f8 · Cited by 34 · see citing works

Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women

Bondonno, C. P., Croft, K. D., Puddey, I. B., Considine, M. J., Yang, X., Ward, N. C., & Hodgson, J. M. (2012) · Food &amp; Function · doi:10.1039/c2fo10206d · Cited by 31 · see citing works

The Endothelium – the Cardiovascular Health Barometer

Herrmann, J., & Lerman, A. (2008) · Herz · doi:10.1007/s00059-008-3088-2 · Cited by 28 · see citing works

Insights into human hypertension: the role of endothelial dysfunction

Giansante, C., & Fiotti, N. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001951 · Cited by 24 · see citing works

Food, nutrition and the nitric oxide pathway : biochemistry and bioactivity

Bryan, N. S. (2010) · Destech Publications eBooks · Cited by 20 · see citing works

Nutritional Epidemiology of Nitrogen Oxides: What do the Numbers Mean?

Lajous, M., & Willett, W. C. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_6 · Cited by 3 · see citing works

Nitrate and Nitrites in Foods: Worldwide Regional Distribution in View of Their Risks and Benefits

Kalaycıoğlu, Z., & Erim, F. B. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01194 · Cited by 132 · see citing works

Nitric oxide and its derivatives in the cancer battlefield

Kamm, A., Przychodzen, P., Kuban-Jankowska, A., Jacewicz, D., Dabrowska, A. M., Nussberger, S., Wozniak, M., & Gorska-Ponikowska, M. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.09.005 · Cited by 120 · see citing works

Cardiovascular Health Benefits of Specific Vegetable Types: A Narrative Review

Blekkenhorst, L. C., Sim, M., Bondonno, C. P., Bondonno, N. P., Ward, N. C., Prince, R. L., Devine, A., Lewis, J. R., & Hodgson, J. M. (2018) · Nutrients · doi:10.3390/nu10050595 · Cited by 118 · see citing works

Polyphenols Regulate Endothelial Functions and Reduce the Risk of Cardiovascular Disease

Yamagata, K. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190722100504 · Cited by 111 · see citing works

Role of dietary antioxidants in the preservation of vascular function and the modulation of health and disease

Varadharaj, S., Kelly, O. J., Khayat, R. N., Kumar, P. S., Ahmed, N., & Zweier, J. L. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00064 · Cited by 101 · see citing works

Oxidation During Digestion of Meat: Interactions with the Diet and Helicobacter pylori Gastritis, and Implications on Human Health

HECKE, T. V., Camp, J. V., & SMET, S. D. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12248 · Cited by 98 · see citing works

Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies

Blekkenhorst, L. C., Bondonno, N. P., Liu, A. H., Ward, N. C., Prince, R. L., Lewis, J. R., Devine, A., Croft, K. D., Hodgson, J. M., & Bondonno, C. P. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx046 · Cited by 89 · see citing works

The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches

Zhu, H.-Y., Hong, F.-F., & Yang, S.-L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094540 · Cited by 84 · see citing works

The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Li, Y. H., Zhu, M., Liu, Y., Luo, B., Cui, J., Huang, L., Chen, K., & Liu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010368 · Cited by 88 · see citing works

Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80 · see citing works

Leafy Vegetable Nitrite and Nitrate Content: Potential Health Effects

Luetic, S., Knezović, Z., Jurcic, K., Majić, Z., Tripkovic, K., & Sutlović, D. (2023) · Foods · doi:10.3390/foods12081655 · Cited by 77 · see citing works

Association of dietary nitrate with atherosclerotic vascular disease mortality: a prospective cohort study of older adult women

Blekkenhorst, L. C., Bondonno, C. P., Lewis, J. R., Devine, A., Woodman, R. J., Croft, K. D., Lim, W. H., Wong, G., Beilin, L. J., Prince, R. L., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.146761 · Cited by 74 · see citing works

Red Light Is Effective in Reducing Nitrate Concentration in Rocket by Increasing Nitrate Reductase Activity, and Contributes to Increased Total Glucosinolates Content

Signore, A., Bell, L., Santamaria, P., Wagstaff, C., & Labeke, M. V. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00604 · Cited by 67 · see citing works

The Importance of Dietary Fiber for Metabolic Health

Bulsiewicz, W. J. (2023) · American Journal of Lifestyle Medicine · doi:10.1177/15598276231167778 · Cited by 66 · see citing works

Cruciferous and Allium Vegetable Intakes are Inversely Associated With 15‐Year Atherosclerotic Vascular Disease Deaths in Older Adult Women

Blekkenhorst, L. C., Bondonno, C. P., Lewis, J. R., Devine, A., Zhu, K., Lim, W. H., Woodman, R. J., Beilin, L. J., Prince, R. L., & Hodgson, J. M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006558 · Cited by 57 · see citing works

Chronic Beetroot Juice Supplementation Accelerates Recovery Kinetics following Simulated Match Play in Soccer Players

Daab, W., Bouzid, M. A., Lajri, M., Bouchiba, M., Saafi, M. A., & Rebai, H. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1735571 · Cited by 56 · see citing works

Nitrate: The Dr. Jekyll and Mr. Hyde of human health?

Bondonno, C. P., Zhong, L., Bondonno, N. P., Sim, M., Blekkenhorst, L. C., Liu, A. H., Rajendra, A., Pokharel, P., Erichsen, D. W., Neubauer, O., et al. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.03.014 · Cited by 56 · see citing works

Mg alloy cardio-/cerebrovascular scaffolds: Developments and prospects

Guan, S., Mei, D., Wang, J., Zhang, Z., Du, P., Bai, L., Yan, C., Li, J., Wang, J., & Zhu, S. (2023) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2023.09.011 · Cited by 54 · see citing works

Effect of exercise training on nitric oxide and nitrate/nitrite (NOx) production: A systematic review and meta-analysis

Arefirad, T., Seif, E., Sepidarkish, M., Khonsari, N. M., Mousavifar, S. A., Yazdani, S., Rahimi, F., Einollahi, F., Heshmati, J., & Qorbani, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.953912 · Cited by 51 · see citing works

Effect of soy products and isoflavones on oxidative stress parameters: A systematic review and meta-analysis of randomized controlled trials

Morvaridzadeh, M., Nachvak, S. M., Agah, S., Sepidarkish, M., Dehghani, F., Rahimlou, M., Pizarro, A. B., & Heshmati, J. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109578 · Cited by 49 · see citing works

Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: a 4-wk randomized controlled crossover trial

Blekkenhorst, L. C., Lewis, J. R., Prince, R. L., Devine, A., Bondonno, N. P., Bondonno, C. P., Wood, L. G., Puddey, I. B., Ward, N. C., Croft, K. D., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy061 · Cited by 49 · see citing works

Development of a Food Composition Database for Assessing Nitrate and Nitrite Intake from Animal‐based Foods

Zhong, L., Liu, A. H., Blekkenhorst, L. C., Bondonno, N. P., Sim, M., Woodman, R. J., Croft, K. D., Lewis, J. R., Hodgson, J. M., & Bondonno, C. P. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100272 · Cited by 45 · see citing works

The Oral Microbiota, Microbial Metabolites, and Immuno-Inflammatory Mechanisms in Cardiovascular Disease

Wang, Z., Kaplan, R. C., Burk, R. D., & Qi, Q. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212337 · Cited by 46 · see citing works

Effects of Probiotic Intervention on Markers of Inflammation and Health Outcomes in Women of Reproductive Age and Their Children

Kwok, K. O., Fries, L. R., Silva‐Zolezzi, I., Thakkar, S. K., Iroz, A., & Blanchard, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.889040 · Cited by 43 · see citing works

Relationship of dietary nitrate intake from vegetables with cardiovascular disease mortality: a prospective study in a cohort of older Australians

Liu, A. H., Bondonno, C. P., Russell, J. C., Flood, V. M., Lewis, J. R., Croft, K. D., Woodman, R. J., Lim, W. H., Kifley, A., Wong, G., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1823-x · Cited by 40 · see citing works

Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases

Liu, Y., Croft, K. D., Hodgson, J. M., Mori, T., & Ward, N. C. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.006 · Cited by 41 · see citing works

Urinary nitrite/nitrate ratio measured by isotope-dilution LC–MS/MS as a tool to screen for urinary tract infections

Chao, M., Shih, Y.-M., Hsu, Y., Liu, H., Chang, Y.-J., Lin, B.-H., & Hu, C. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.025 · Cited by 37 · see citing works

Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery

Collins, P., Earnest, C. P., Dalton, R., Sowinski, R. J., Grubic, T., Favot, C., Coletta, A. M., Rasmussen, C. J., Greenwood, M., & Kreider, R. B. (2017) · Nutrients · doi:10.3390/nu9080823 · Cited by 38 · see citing works

Anti-inflammatory effects of probiotics and synbiotics on patients with non-alcoholic fatty liver disease: An umbrella study on meta-analyses

Mahapatro, A., Bawna, F., Kumar, V., Daryagasht, A. A., Gupta, S., Raghuma, N., Moghdam, S. S., Kolla, A., Mahapatra, S. S., Sattari, N., et al. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.07.087 · Cited by 37 · see citing works

Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite

Dent, M. R., DeMartino, A. W., Tejero, J., & Gladwin, M. T. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c01048 · Cited by 35 · see citing works

Dietary intake and health risk assessment of nitrate, nitrite, and nitrosamines: a Bayesian analysis and Monte Carlo simulation

Moazeni, M., Heidari, Z., Gholipour, S., Ghaisari, L., Sillanpää, M. E. T., & Ebrahimi, A. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-10494-9 · Cited by 34 · see citing works

A review on nitrates’ health benefits and disease prevention

Apte, M., Nadavade, N., & Sheikh, S. S. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.11.003 · Cited by 35 · see citing works

Effects of a dietary strawberry powder on parameters of vascular health in adolescent males

Djurica, D., Holt, R. R., Ren, J., Shindel, A. W., Hackman, R. M., & Keen, C. L. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002348 · Cited by 34 · see citing works

Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives

Tănase, D. M., Apostol, A. G., Costea, C. F., Tărniceriu, C. C., Tudorancea, I., Maranducă, M. A., Floria, M., & Șerban, I. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030534 · Cited by 34 · see citing works

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Romandini, M., Hajishengallis, G., Curtis, M. A., & Baima, G. (2026) · Journal of Periodontal Research · doi:10.1111/jre.70099 · Cited by 33 · see citing works

Beetroot and Sodium Nitrate Ameliorate Cardiometabolic Changes in Diet‐Induced Obese Hypertensive Rats

Bhaswant, M., Brown, L., McAinch, A. J., & Mathai, M. L. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700478 · Cited by 30 · see citing works

Pre-harvest Nitrogen Limitation and Continuous Lighting Improve the Quality and Flavor of Lettuce (Lactuca sativa L.) under Hydroponic Conditions in Greenhouse

Yang, X., Hu, J., Wang, Z., Huang, T., Xiang, Y., Zhang, L., Peng, J., Tomás-Barberán, F. A., & Yang, Q. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07420 · Cited by 29 · see citing works

Nitrate and Nitrite in the Diet: Protective and Harmful Effects in Health and Disease

Sokal-Dembowska, A., Jarmakiewicz-Czaja, S., Tabarkiewicz, J., & Filip, R. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00678-5 · Cited by 32 · see citing works

A novel therapeutic effect of mannitol-rich extract from the brown seaweed Sargassum ilicifolium using in vitro and in vivo models

Premarathna, A. D., Tuvikene, R., Somasiri, M., Silva, M. D., Adhikari, R. B., Ranahewa, T. H., Wijesundara, R. R. M. K. K., Wijesekera, S. K., Dissanayake, I., Wangchuk, P., et al. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03840-0 · Cited by 27 · see citing works

A fuzzy-based decision making software for enzymatic electrochemical nitrate biosensors

Vakilian, K. A., & Massah, J. (2018) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2018.04.016 · Cited by 26 · see citing works

Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE−/− mouse fed a high fat diet

Bakker, J. R., Bondonno, N. P., Gaspari, T. A., Kemp‐Harper, B. K., McCashney, A. J., Hodgson, J. M., Croft, K. D., & Ward, N. C. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.009 · Cited by 25 · see citing works

Effect of dietary nitrate ingestion on muscular performance: a systematic review and meta-analysis of randomized controlled trials

Álvares, T. S., de Oliveira, G. V., Volino‐Souza, M., Conte‐Júnior, C. A., & Murias, J. M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1884040 · Cited by 26 · see citing works

Effects of Combined Application of Organic Fertilizer on the Growth and Yield of Pakchoi under Different Irrigation Water Types

Lin, S., Wang, C., Lei, Q., Wei, K., Wang, Q., Deng, M., Su, L., Liu, S., & Duan, X. (2023) · Agronomy · doi:10.3390/agronomy13102468 · Cited by 23 · see citing works

Acute oral dose of sodium nitrite causes redox imbalance and DNA damage in rat kidney

Ansari, F. A., Ali, S. N., Khan, A. A., & Mahmood, R. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26611 · Cited by 21 · see citing works

Mouthwash use and risk of diabetes

Preshaw, P. M. (2018) · BDJ · doi:10.1038/sj.bdj.2018.1020 · Cited by 20 · see citing works

Evaluation of nitrate contents in regulated and non-regulated leafy vegetables of high consumption in the Canary Islands, Spain: Risk assessment

León, V. M., & Luzardo, O. P. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111812 · Cited by 22 · see citing works

Association of Dietary Nitrate Intake with the 15-Year Incidence of Age-Related Macular Degeneration

Gopinath, B., Liew, G., Kifley, A., Lewis, J. R., Bondonno, C. P., Joachim, N., Hodgson, J. M., & Mitchell, P. (2018) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2018.07.012 · Cited by 19 · see citing works

Acute Effects of Dietary Nitrate on Exercise Tolerance, Muscle Oxygenation, and Cardiovascular Function in Patients With Peripheral Arterial Disease

van der Avoort, C. M. T., van Loon, L. J. C., Verdijk, L. B., Poyck, P. P. C., Thijssen, D. T. J., & Hopman, M. T. E. (2021) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2021-0054 · Cited by 18 · see citing works

Association of Dietary Nitrate and a Mediterranean Diet With Age-Related Macular Degeneration Among US Adults

Broadhead, G., Agrón, E., Peprah, D., Keenan, T. D. L., Lawler, T. P., Mares, J. A., Chew, E. Y., AREDS/AREDS2 Investigators, SanGiovanni, J., Ferris, F., et al. (2022) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2022.5404 · Cited by 18 · see citing works

The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion

McCarty, M. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0056 · Cited by 16 · see citing works

Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial

Alharbi, M., Chiurazzi, M., Nasti, G., Muscariello, E., Mastantuono, T., Köchl, C., Stephan, B. C. M., Shannon, O. M., Colantuoni, A., & Siervo, M. (2023) · Nutrients · doi:10.3390/nu15040890 · Cited by 14 · see citing works

Potential role of dietary nitrate in relation to cardiovascular and cerebrovascular health, cognition, cognitive decline and dementia: a review

Rajendra, A., Bondonno, N. P., Rainey‐Smith, S. R., Gardener, S. L., Hodgson, J. M., & Bondonno, C. P. (2022) · Food & Function · doi:10.1039/d2fo02427f · Cited by 14 · see citing works

Oral nitrate-reducing bacteria as potential probiotics for blood pressure homeostasis

Chai, X., Liu, L., & Chen, F. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1337281 · Cited by 15 · see citing works

Transcriptome analysis reveals the differential regulatory effects of red and blue light on nitrate metabolism in pakchoi (Brassica campestris L.)

Fan, X., Zhong-hua, B. I. A. N., Bo, S. O. N. G., & Xu, H. (2022) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(21)63784-x · Cited by 12 · see citing works

HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1

Cheng, H., Lu, T., Wang, J., Xia, Y., Chai, X., Zhang, M., Yao, Y., Zhou, N., Zhou, S., Chen, X., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00201 · Cited by 13 · see citing works

Water Quality Standards

Saleh, H. M., & Hassan, A. I. (2021) · Wiley eBooks · doi:10.1002/9781119725237.ch17 · Cited by 13 · see citing works

Implication of self-organizing map, stable isotopes combined with MixSIAR model for accurate nitrogen control in a well-protected reservoir

Lin, C., Du, R., & Guo, F. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118335 · Cited by 12 · see citing works

Effects of Cooking Conditions on the Relationships Among Oxalate, Nitrate, and Lutein in Spinach

Wang, Z., Ando, A., Takeuchi, A., & Ueda, H. (2018) · Food Science and Technology Research · doi:10.3136/fstr.24.421 · Cited by 12 · see citing works

Investigation of the interaction of the cationic nitrosyl iron complex [Fe(SC(NH2)2)2(NO)2]+ with molecular oxygen

Emel’yanova, N. S., Gutsev, L. G., Pokidova, O. V., Shestakov, A. F., Санина, Н. А., & Aldoshin, S. M. (2021) · Inorganica Chimica Acta · doi:10.1016/j.ica.2021.120361 · Cited by 12 · see citing works

Dietary Nitrate Intake Is Associated with Decreased Incidence of Open-Angle Glaucoma: The Rotterdam Study

Vergroesen, J. E., de Crom, T. O. E., Blekkenhorst, L. C., Klaver, C. C. W., Voortman, T., & Ramdas, W. D. (2022) · Nutrients · doi:10.3390/nu14122490 · Cited by 13 · see citing works

Concurrent dietary intake to nitrate, thiocyanate, and perchlorate is negatively associated with hypertension in adults in the USA

Xu, D., Zhu, X., Xie, X., Huang, C., Fang, X., & Yin, T. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-23093-7 · Cited by 12 · see citing works

Wild Watermelon-Extracted Juice Ingestion Reduces Peripheral Arterial Stiffness with an Increase in Nitric Oxide Production: A Randomized Crossover Pilot Study

Fujie, S. J., Iemitsu, K., Inoue, K., Ogawa, T., Nakashima, A., Suzuki, K., & Iemitsu, M. (2022) · Nutrients · doi:10.3390/nu14245199 · Cited by 12 · see citing works

Acute inorganic nitrate intake increases regional insulin action in the brain: Results of a double-blind, randomized, controlled cross-over trial with abdominally obese men

Kleinloog, J., Mensink, R., Smeets, E., Ivanov, D., & Joris, P. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103115 · Cited by 9 · see citing works

Evaluation of Apricot, Bilberry, and Elderberry Pomace Constituents and Their Potential To Enhance the Endothelial Nitric Oxide Synthase (eNOS) Activity

Waldbauer, K., Seiringer, G., Sykora, C., Dirsch, V. M., Zehl, M., & Kopp, B. (2018) · ACS Omega · doi:10.1021/acsomega.8b00638 · Cited by 11 · see citing works

Association of dietary nitrate intake with retinal microvascular structure in older adults

Gopinath, B., Liew, G., Lewis, J. R., Blekkenhorst, L. C., Bondonno, C. P., Burlutsky, G., Hodgson, J. M., & Mitchell, P. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02055-9 · Cited by 11 · see citing works

Short communication: Effects of dietary N-carbamoylglutamate supplementation on the milk amino acid profile and mozzarella cheese quality in mid-lactating dairy cows

Gu, F., Wang, D., Yang, D., Liu, J., & Ren, D. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17385 · Cited by 11 · see citing works

Effects of Beetroot Powder with or without L-Arginine on Postprandial Vascular Endothelial Function: Results of a Randomized Controlled Trial with Abdominally Obese Men

Smeets, E. T. H. C., Mensink, R. P., Joris Hoeks, J., den Bosch, J. D. V., Hageman, R. J. J., & Joris, P. J. (2020) · Nutrients · doi:10.3390/nu12113520 · Cited by 9 · see citing works

Dietary Beetroot Juice – Effects in Patients with COPD: A Review

Chen, M., Chang, S., Xu, Y., Parke, H. G., & Liu, J. (2024) · International Journal of COPD · doi:10.2147/copd.s473397 · Cited by 8 · see citing works

An Evidence-Based Review of Application Devices for Nitric Oxide Concentration Determination from Exhaled Air in the Diagnosis of Inflammation and Treatment Monitoring

Wyszyńska, M., Nitsze-Wierzba, M., Czelakowska, A., Kasperski, J., Żywiec, J., & Skucha-Nowak, M. (2022) · Molecules · doi:10.3390/molecules27134279 · Cited by 8 · see citing works

A Single Dosage of l-Arginine Oral Supplementation Induced Post-Aerobic Exercise Hypotension in Hypertensive Patients

Casonatto, J., & Cavalari, J. V. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2022.2106006 · Cited by 6 · see citing works

The effects of cannabidiol on nitric oxide synthases: a narrative review on therapeutic implications for inflammation and oxidative stress in health and disease

Hooshmand, S. A. A., Rameshrad, M., Sahebkar, A., & Iranshahi, M. (2025) · Journal of Cannabis Research · doi:10.1186/s42238-025-00332-5 · Cited by 7 · see citing works

A Study on Vascular Regulators as Early Biomarkers of Hand Arm Vibration Syndrome

Yang, H., Chen, Z., Xiuwen, H. U., Wei, N., Li, J., Yuan, W., & Chen, Q. (2023) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000002957 · Cited by 7 · see citing works

Exposure to nitrate and nitrite disrupts cardiovascular development through estrogen receptor in zebrafish embryos and larvae

Saputra, F., Hu, S., & Kishida, M. (2024) · Fish Physiology and Biochemistry · doi:10.1007/s10695-024-01381-y · Cited by 7 · see citing works

Carnosine and N‐acetyl cysteine protect against sodium nitrite‐induced oxidative stress in rat blood

Ansari, F. A., & Mahmood, R. (2017) · Cell Biology International · doi:10.1002/cbin.10893 · Cited by 7 · see citing works

Hirudin-Based Treatment of Diabetes-Induced Erectile Dysfunction Through Inhibition of the HIF-1α to Regulate RhoA/ROCK Signaling Pathway: An In Vivo Animal Experiment

Sun, L., Huang, N., Yang, C., Feng, J., Chen, H., Feng, W., Gao, Z., Wang, B., & Wang, J. (2025) · American Journal of Men s Health · doi:10.1177/15579883241310763 · Cited by 6 · see citing works

Tongue-coating microbiome reflects cardiovascular health and determines outcome in blood pressure intervention

Chen, H., Ma, Y., Li, M., Li, Q., Zhang, M., Wang, Z., Liu, H., Wang, J., Tong, X., & Zeng, Y. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.01.003 · Cited by 6 · see citing works

Plasma hydrogen sulfide, nitric oxide, and thiocyanate levels are lower during pregnancy compared to postpartum in a cohort of women from the Pacific northwest of the United States

Zeigler, M. B., Fay, E., Moreni, S. L., Mao, J., Totah, R. A., & Hébert, M. F. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121625 · Cited by 6 · see citing works

Isolation of nitrite‐degrading strains from Douchi and their application to degrade high nitrite in Jiangshui

Guo, X., Liu, B., Gao, L., Zhou, Y., Shan, Y., & Lü, X. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9163 · Cited by 6 · see citing works

Synthesis and Modeling Studies of Furoxan Coupled Spiro-Isoquinolino Piperidine Derivatives as NO Releasing PDE 5 Inhibitors

Swami, P. M., Tamboli, Y., Choudhari, P. B., Bhatia, M. S., Mohanta, T. K., Al‐Harrasi, A., & Pudukulathan, Z. K. (2020) · Biomedicines · doi:10.3390/biomedicines8050121 · Cited by 6 · see citing works

Endothelial, Cardiovascular, and Performance Responses to L-arginine Intake and Resistance Exercise

Streeter, D. M., Trautman, K. A., Bennett, T. W., McIntosh, L. E., Grier, J. W., Stastny, S., & Hackney, K. J. (2019) · International journal of exercise science · doi:10.70252/sqvu9671 · Cited by 6 · see citing works

Anti-hypertensive Function of Plant-derived Bioactive Peptides: A Review

Gochhi, M., Dash, P., Kar, B., Pradhan, D., Halder, J., Das, C., Rai, V. K., Rout, S. K., Ghosh, G., & Rath, G. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128386781250415105515 · Cited by 5 · see citing works

Transcriptional, physiological and ultrastructure levels revealed silicon enhanced cadmium detoxification and functional compound accumulation in pakchoi

Liu, Z., Qin, M., Li, R., Zhou, Y., Yan, J., Ahmad, P., El‐Sheikh, M. A., Yang, L., Liu, P., & Shi, Q. (2024) · LWT · doi:10.1016/j.lwt.2024.117253 · Cited by 5 · see citing works

APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan

Rasmussen, P. M., Aamand, R., Weitzberg, E., Christiansen, M., Østergaard, L., & Lund, T. E. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101955 · Cited by 5 · see citing works

Endothelial Hyper-Permeability Induced by T1D Sera Can be Reversed by iNOS Inactivation

Cazzaniga, A., Scrimieri, R., Giani, E., Zuccotti, G., & Maier, J. A. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082798 · Cited by 5 · see citing works

Acute Effects of Inorganic Nitrate Intake on Brachial and Femoral Flow-Mediated Vasodilation, and on Carotid Artery Reactivity Responses: Results of a Randomized, Double-Blinded, Placebo-Controlled Cross-Over Study in Abdominally Obese Men

Smeets, E. T. H. C., Mensink, R. P., Kleinloog, J. P. D., & Joris, P. J. (2022) · Nutrients · doi:10.3390/nu14173560 · Cited by 5 · see citing works

Allergic activation of mast cells.

Parker, C. W. (1986) · PubMed · Cited by 5 · see citing works

Healing the heart naturally: The role of bioactive phytocompounds in cardiovascular therapeutics

Anand, A. K., Srivastava, S., Sharma, D., Sridhar, S. B., Tariq, M., Rao, G. S. N. K., Mruthunjaya, K., Manjula, S. N., Sahu, R., & Hamida, M. B. B. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158084 · Cited by 4 · see citing works

The role of gut microbiota augmentation in managing non-alcoholic fatty liver disease: an in-depth umbrella review of meta-analyses with grade assessment

Maddineni, G., Obulareddy, S. J., Paladiya, R. D., Korsapati, R. R., Jain, S., Jeanty, H., Vikash, F., Tummala, N., Shetty, S., Ghazalgoo, A., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002276 · Cited by 4 · see citing works

Chronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity

Sowton, A. P., Holzner, L. M. W., Krause, F. N., Baxter, R. M., Mocciaro, G., Krzyzanska, D., Minnion, M., O’Brien, K. A., Harrop, M. C., Darwin, P. M., et al. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00256.2024 · Cited by 4 · see citing works

Urinary Nitric Oxide Levels Are Associated with Blood Pressure, Fruit and Vegetable Intake and Total Polyphenol Excretion in Adolescents from the SI! Program

Ramírez-Garza, S. L., Santos, E. P. L., Arancibia‐Riveros, C., Carrasco-Jiménez, J. C., Bodega, P., de Cos-Gandoy, A., de Miguel, M., Santos-Beneit, G., Fernández-Alvira, J. M., Fernández‐Jiménez, R., et al. (2022) · Antioxidants · doi:10.3390/antiox11112140 · Cited by 4 · see citing works

Are Chokeberry Products Safe for Health? Evaluation of the Content of Contaminants and Health Risk

Olechno, E., Puścion‐Jakubik, A., Soroczyńska, J., Socha, K., & Zujko, M. E. (2023) · Foods · doi:10.3390/foods12173271 · Cited by 4 · see citing works

Effect of F Substituents in Thiophenol on the Structure and Properties of µ2-S-(Difluorothiolate)tetranitrosyl Iron Binuclear Complexes

Санина, Н. А., Konyukhova, A. S., Корчагин, Д. В., Ovanesyan, N. S., Куликов, А. В., Mumyatova, V. A., Терентьев, А. А., & Aldoshin, S. M. (2023) · Russian Journal of Inorganic Chemistry · doi:10.1134/s0036023623601526 · Cited by 4 · see citing works

Quantum chemical modeling in the system polyvinylpyrrolidone—cation of the dinitrosyl iron complex

Ignat’ev, V. M., Emel’yanova, N. S., & Санина, Н. А. (2020) · Russian Chemical Bulletin · doi:10.1007/s11172-020-3045-7 · Cited by 4 · see citing works

Accelerated Arterial Stiffening Change in Early Years of Spinal Cord Injury

Wu, H.-M., Chu, B.-Y., Hsu, C., Wang, C.-W., Wong, M., & Huang, S.-C. (2016) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000565 · Cited by 4 · see citing works

Chronic nitrite treatment activates adenosine monophosphate-activated protein kinase-endothelial nitric oxide synthase pathway in human aortic endothelial cells

Liu, Y., Croft, K. D., Hodgson, J. M., Mori, T. A., & Ward, N. C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104447 · Cited by 4 · see citing works

Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis

Dong, Y., Zhang, Y., Lin, Z., Li, X., Guo, Z., Tian, L., Ma, F., & Li, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.041 · Cited by 3 · see citing works

Prenatal nitrate and nitrite intake in mammals: A scoping review of effects and associations with pregnancy and maternal and child health.

Kardol, L. R., Rhaman, A., Kelty, E., Morgan, S., Russell, D. J., Gebremedhin, A., Bourke, S., & Wyrwoll, C. (2025) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2025.114712 · Cited by 3 · see citing works

Harnessing the gut-heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategies.

Chandra, Q. M., Clister, D., Halim, P., Dalimunthe, A., Ichwan, M., Sari, D. K., Umaya, C., Aktary, N., Rani, A., Park, M. N., et al. (2026) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2026.120941 · Cited by 3 · see citing works

The nitrate–nitrite–nitric oxide pathway of neuroinflammation and cognitive impairment in ischemic stroke

Liu, J., Deng, Q., Wei, S., Cheng, L., Shen, C., Liu, Z., Qiu, Y., Teng, J., Wang, L., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1790943 · Cited by 4 · see citing works

Metabolomics study of APETx2 post-conditioning on myocardial ischemia-reperfusion injury

Li, J., Wei, Y., Wang, Y., Zhang, Y., Xu, Y., Ma, H., Ma, L., & Zeng, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1470142 · Cited by 3 · see citing works

Vegetable-derived bioactive nitrate and cardiovascular health

Bondonno, C. P., Blekkenhorst, L. C., Liu, A. H., Bondonno, N. P., Ward, N. C., Croft, K. D., & Hodgson, J. M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.08.001 · Cited by 101 · see citing works

Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits

Machha, A., & Schechter, A. N. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0192-5 · Cited by 146 · see citing works

Roles of dietary inorganic nitrate in cardiovascular health and disease

Lundberg, J. O., Carlström, M., Larsen, F. J., & Weitzberg, E. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq325 · Cited by 355 · see citing works

Nitric oxide mediated cardiovascular benefits of dietary nitrate and polyphenols

Bondonno, C. P. (2012) · UWA Profiles and Research Repository (University of Western Australia)

Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies

Blekkenhorst, L. C., Bondonno, N. P., Liu, A. H., Ward, N. C., Prince, R. L., Lewis, J. R., Devine, A., Croft, K. D., Hodgson, J. M., & Bondonno, C. P. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx046 · Cited by 89 · see citing works