The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP

He, Zongze; Wang, Yujue; Huang, Guangfu; Wang, Qi; Zhao, Dongdong; Chen, Longyi

doi:10.1016/j.abb.2017.01.013

Cited by 83Cancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases

The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP

He, Zongze, Wang, Yujue, Huang, Guangfu, Wang, Qi, Zhao, Dongdong, Chen, Longyi·2017·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2017.01.013

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Abstract

Long non-coding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) has been reported to be involved in the development and progression of many types of tumors including breast cancer, gastric cancer, and bladder cancer. However, the exact effects and molecular mechanisms of UCA1 in glioma progression remain unclear up to now. In this study, we firstly found that UCA1 was upregulated in glioma tumor samples and negatively correlated with survival time. Then, we investigated the role of UCA1 in human glioma cell lines. Our results showed that upregulation of lncRNA-UCA1 in glioma tissues and cell lines could promote glioma cell proliferation and migration through interaction with miR-182, and knockdown of UCA1 inhibited the proliferation and migration of human glioma cell. In addition, miR-182 dependent inhibitor of apoptosis-stimulating protein of p53 (iASPP) was required in the regulation of UCA1 induced glioma cell proliferation. Taken together, UCA1 might promote proliferation and migration of glioma, to regulate the tumor growth and metastasis via miR-182 dependent iASPP regulation. Therefore, lncRNA-UCA1 could be regarded as a therapeutic target in human glioma.

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Two lncRNAs, H19 and UCA1, regulate glioblastoma progression by interacting with mir-140 and mir-182, respectively.
“Two lncRNAs, H19 and UCA1, regulate GBM progression by interacting with mir-140 and mir-182, respectively.”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [57]
H19 and UCA1 reduce the expression and activity of mir-140 and mir-182, and therefore possess p53-dependent oncogenic activity in glioblastoma.
“H19 and UCA1 reduce the expression and activity of these miRNAs, and therefore possess p53-dependent oncogenic activity in GBM [57,58].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [57]

1 retracted

MicroRNA-124 Regulates the Proliferation of Colorectal Cancer Cells by TargetingiASPP
Liu, K., Zhao, H., Yao, H., Lei, S., Lei, Z., Li, T., & Qi, H. (2013) · BioMed Research International · doi:10.1155/2013/867537 · Cited by 56 · see citing works
Retracted
Landscape of transcription in human cells
Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., et al. (2012) · Nature · doi:10.1038/nature11233 · Cited by 5,187 · see citing works
Evolution and Functions of Long Noncoding RNAs
Ponting, C. P., Oliver, P. L., & Reik, W. (2009) · Cell · doi:10.1016/j.cell.2009.02.006 · Cited by 4,917 · see citing works
Analyzing MiRNA–LncRNA Interactions
Paraskevopoulou, M. D., & Hatzigeorgiou, A. G. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3378-5_21 · Cited by 895 · see citing works
Standards of care for treatment of recurrent glioblastoma—are we there yet?
Weller, M., Cloughesy, T. F., Perry, J., & Wick, W. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos273 · Cited by 766 · see citing works
Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer
Martens‐Uzunova, E. S., Böttcher, R., Croce, C. M., Jenster, G. W., Visakorpi, T., & Călin, G. A. (2013) · European Urology · doi:10.1016/j.eururo.2013.12.003 · Cited by 656 · see citing works
LncRNA-UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p
Nie, W., Ge, H., Yang, X., Sun, X., Huang, H., Tao, X., Chen, W., & Li, B. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.11.024 · Cited by 354 · see citing works
Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143.
Yl, T., Xm, L., & Luo, J. (2015) · PubMed · Cited by 286 · see citing works
UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution
Han, Y., Yang, Y., Yuan, H.-H., Zhang, T., Sui, H., Wei, X.-L., Liu, L., Huang, P., Zhang, W., & Bai, Y. (2014) · Pathology · doi:10.1097/pat.0000000000000125 · Cited by 241 · see citing works
Regulation of lncRNA expression
Wu, Z., Liu, X., Liu, L., Deng, H., Zhang, J., Xu, Q., Cen, B., & Ji, A. (2014) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-014-0212-6 · Cited by 233 · see citing works
The Central Nervous System
Frosch, M. P., Anthony, D. C., & Girolami, U. D. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0792-2.50033-x · Cited by 228 · see citing works
Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells
Pan, J., Li, X., Wu, W., Xue, M., Hou, H., Zhai, W., & Chen, W. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.015 · Cited by 217 · see citing works
Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification.
Vigneswaran, K., Neill, S. G., & Hadjipanayis, C. G. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.57 · Cited by 157 · see citing works
MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma
Wang, L., Shi, Z., Jiang, C., Liu, X., Chen, Q.-D., Qian, X., Li, D., Ge, X. Q., Wang, X.-F., Liu, L.-Z., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2116 · Cited by 143 · see citing works
Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer
Li, H.-J., Li, X., Pang, H., Pan, J., Xie, X., & Chen, W. (2015) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyv132 · Cited by 137 · see citing works
LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway.
Xiao, C., Ch, W., & Hz, H. (2016) · PubMed · Cited by 136 · see citing works
Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer
Shang, C., Guo, Y., Zhang, J., & Huang, B. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3029-3 · Cited by 116 · see citing works
Analysis of the mi RNA – mRNA –lnc RNA networks in ER + and ER − breast cancer cell lines
Wu, Q., Guo, L., Jiang, F., Li, L., Zhong, L., & Chen, F. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12681 · Cited by 106 · see citing works
An emerging understanding of long noncoding RNAs in kidney cancer
Zhou, S., Wang, J., & Zhang, Z. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1699-y · Cited by 105 · see citing works
LncRNA UCA1-miR-507-FOXM1 axis is involved in cell proliferation, invasion and G0/G1 cell cycle arrest in melanoma
Wei, Y., Sun, Q., Zhao, L., Wu, J., Chen, X., Wang, Y., Zang, W., & Zhao, G. (2016) · Medical Oncology · doi:10.1007/s12032-016-0804-2 · Cited by 97 · see citing works
Self-citation
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Zhao, H., Peng, R., Liu, Q., Liu, D., Du, P., Yuan, J., Peng, G., & Liao, Y. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.09.014 · Cited by 86 · see citing works
Expression of Concern: Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor‐suppressive miR‐124
Li, A., Lin, X., Tan, X., Yin, B., Han, W., Zhao, J., Yuan, J., Qiang, B., & Peng, X. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.06.018 · Cited by 85 · see citing works
Suppression of miR-184 in malignant gliomas upregulates SND1 and promotes tumor aggressiveness
Emdad, L., Janjic, A., Alzubi, M. A., Hu, B., Santhekadur, P. K., Menezes, M. E., Shen, X., Das, S. K., Sarkar, D., & Fisher, P. B. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou220 · Cited by 83 · see citing works
Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation
Tao, T., Cheng, C., Ji, Y., Xu, G., Zhang, J., Zhang, L., & Shen, A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0805 · Cited by 75 · see citing works
microRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis
Yang, M., Yu, J., Jiang, D., Li, W., Wang, S., & Ding, Y. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-109 · Cited by 71 · see citing works
MiR-129-2 functions as a tumor suppressor in glioma cells by targeting HMGB1 and is down-regulated by DNA methylation
Yu, Y., Huang, J., Zhang, X., & Shen, L. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2382-6 · Cited by 68 · see citing works
microRNA-214-mediated UBC9 expression in glioma
Zhao, Z., Tan, X., Zhao, A.-N., Zhu, L., Yin, B., Yuan, J., Qiang, B., & Peng, X. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.11.097 · Cited by 50 · see citing works
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
Sun, J., Ji, J., Huo, G., Song, Q., & Zhang, X. (2015) · PubMed Central · Cited by 50 · see citing works
Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling
Turchi, L., Debruyne, D. N., Almairac, F., Virolle, V., Fareh, M., Neirijnck, Y., Burel‐Vandenbos, F., Paquis, P., Junier, M., Obberghen‐Schilling, E. V., et al. (2013) · Stem Cells · doi:10.1002/stem.1373 · Cited by 50 · see citing works
Central nervous system
Adamson, D. C., Rasheed, B. A., McLendon, R. E., & Bigner, D. D. (2011) · Cancer Biomarkers · doi:10.3233/cbm-2011-0177 · Cited by 45 · see citing works
Long non-coding RNA UCA1 is a predictive biomarker of cancer
Hong, H., Hou, L., Pan, X., Wu, C., Huang, H., Li, B., & Nie, W. (2016) · Oncotarget · doi:10.18632/oncotarget.10142 · Cited by 44 · see citing works
脳内出血で発症した転移性extraskeletal myxoid chondrosarcomaの1例
晏, 小., 寺川雄三, 徹, 山., & 中西, 愛. (2008) · Neuro-Oncology · doi:10.11452/neurooncology2005.17.1_1 · Cited by 34 · see citing works
iASPP Inhibition: Increased Options in Targeting the p53 Family for Cancer Therapy
Bell, H. S., & Ryan, K. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0182 · Cited by 33 · see citing works
MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP)
Yi, H., Huang, Y., Yang, F., Liu, W., He, S., & Hu, X. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.05.002 · Cited by 32 · see citing works
Silencing of UCA1, a poor prognostic factor, inhibited the migration of endometrial cancer cell
Lü, L., Shen, Y., Tseng, K., Liu, W., Duan, H., & Meng, W. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160628 · Cited by 32 · see citing works
MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP.
Chen, J., Xiao, H., Huang, Z., Hu, Z., Qi, T., Zhang, B., Tao, X., & Liu, S. (2014) · PubMed Central · Cited by 20 · see citing works
Biomarker analysis of on-treatment and at progression biopsies from BRIM7 - a phase 1B trial of combined vemurafenib and cobimetinib treatment in BRAF V600 mutated melanoma
Yan, Y., McArthur, G. A., Hamid, O., Puzanov, I. J., Gonzalez, R. C., Gajewski, T. F., Wang, Y., Wongchenko, M. J., Choong, N. W., & Ribas, A. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-s1-o12 · Cited by 18 · see citing works
Self-citation
Overexpression of iASPP-SV in glioma is associated with poor prognosis by promoting cell viability and antagonizing apoptosis
Liu, X., Kang, J. P., Liu, F., Wen, S., Zeng, X., Liu, K., Luo, Y., Ji, X., & Zhao, S. (2015) · Tumor Biology · doi:10.1007/s13277-015-4503-y · Cited by 15 · see citing works
Gene expression profiling of microRNAs associated with UCA1 in bladder cancer cells
Xie, X., Pan, J., Wei, L.-Q., Wu, S., Hou, H., Li, X., & Chen, W. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3357 · Cited by 13 · see citing works

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Zhang, Y., Dube, C., Gibert, M., Cruickshanks, N., Wang, B., Coughlan, M., Yang, Y., Setiady, I., Deveau, C., Saoud, K., et al. (2018) · Cancers · doi:10.3390/cancers10090297 · Cited by 440 · see citing works
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Rynkeviciene, R., Simiene, J., Strainiene, E., Stankevicius, V., Usinskiene, J., Miseikyte Kaubriene, E., Meskinyte, I., Cicenas, J., & Suziedelis, K. (2018) · Cancers · doi:10.3390/cancers11010017 · Cited by 136 · see citing works
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Voce, D. J., Bernal, G. M., Wu, L., Crawley, C. D., Zhang, W., Mansour, N. M., Cahill, K. E., Szymura, S. J., Uppal, A., Raleigh, D. R., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2170 · Cited by 92 · see citing works
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Xu, F., & Zhang, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.103 · Cited by 89 · see citing works
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Wu, Y., Shao, A., Wang, L., Hu, K., Yu, C., Pan, C., & Zhang, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00407 · Cited by 89 · see citing works
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Yu, L., Zhao, J. K., & Gao, L. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.23350 · Cited by 87 · see citing works
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Shao, T., Wang, G., Chen, H., Xie, Y., Jin, X., Bai, J., Xu, J., Li, X., Huang, J. H., Jin, Y., et al. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby038 · Cited by 61 · see citing works
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Retracted
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Ramaiah, M. J., Karthikeyan, D., Kumar, S. K., & Yamajala, R. B. R. D. (2019) · Gene · doi:10.1016/j.gene.2019.144126 · Cited by 27 · see citing works
Long non-coding RNAs in brain tumors
Katsushima, K., Jallo, G. I., Eberhart, C. G., & Perera, R. J. (2021) · NAR Cancer · doi:10.1093/narcan/zcaa041 · Cited by 24 · see citing works
Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets
Kciuk, M., Yahya, E. B., Mohamed, M. M. I., Abdulsamad, M. A., Allaq, A. A., Gielecińska, A., & Kontek, R. (2023) · Cancers · doi:10.3390/cancers15133298 · Cited by 28 · see citing works
Identification of transcription factor-miRNA-lncRNA feed-forward loops in breast cancer subtypes
Jiang, L., Yu, X., Ma, X., Liu, H., Zhou, S., Zhou, X., Meng, Q., Wang, L., & Jiang, W. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.11.008 · Cited by 25 · see citing works
Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials
Zeng, T., Li, L., Zhou, Y., & Gao, L. (2018) · International Journal of Genomics · doi:10.1155/2018/2895958 · Cited by 24 · see citing works
Long non-coding RNAs as epigenetic mediator and predictor of glioma progression, invasiveness, and prognosis
Zhang, Y., Xiao, Y., Li, G., Gong, F., Zhang, X., & Hou, K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.08.016 · Cited by 23 · see citing works
Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets
Yadav, G., & Kulshreshtha, R. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30577 · Cited by 22 · see citing works
Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer
Horita, K., Kurosaki, H., Nakatake, M., Ito, M., Kono, H., & Nakamura, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.125 · Cited by 22 · see citing works
LncRNA UCA1/miR-182-5p/MGMT axis modulates glioma cell sensitivity to temozolomide through MGMT-related DNA damage pathways
Cheng, M., Wang, Q., Chen, L., Zhao, D., Tang, J. X., Xu, J., & He, Z. (2022) · Human Pathology · doi:10.1016/j.humpath.2022.02.016 · Cited by 22 · see citing works
Self-citation
RAD21 inhibited transcription of tumor suppressor MIR4697HG and led to glioma tumorigenesis
Mao, Y., Shen, G., Su, Z., Du, J., Xu, F., & Yu, Y. Q. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109759 · Cited by 21 · see citing works
Augmented expression levels of lncRNAs ecCEBPA and UCA1 in gastric cancer tissues and their clinical significance.
Nasrollahzadeh-Khakiani, M., Emadi‐Baygi, M., & Nikpour, P. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.9448 · Cited by 20 · see citing works
Prospective Series of Nine Long Noncoding RNAs Associated with Survival of Patients with Glioblastoma
Lei, B., Yu, L., Jung, T., Deng, Y., Xiang, W., Liu, Y., & Qi, S. (2018) · Journal of Neurological Surgery Part A Central European Neurosurgery · doi:10.1055/s-0038-1655549 · Cited by 20 · see citing works
Current insights on extracellular vesicle-mediated glioblastoma progression: Implications in drug resistance and epithelial-mesenchymal transition
Mukherjee, S., & Pillai, P. P. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130065 · Cited by 18 · see citing works
Long non‐coding RNA SNHG17 promotes proliferation, migration and invasion of glioma cells by regulating the miR‐23b‐3p/ZHX1 axis
Ge, B., & Li, G. (2020) · The Journal of Gene Medicine · doi:10.1002/jgm.3247 · Cited by 18 · see citing works
Retracted : Knockdown of long noncoding RNA urothelial carcinoma–associated 1 inhibits cell viability, migration, and invasion by regulating microRNA‐182 in gastric carcinoma
Qin, L., Jia, Z., Xie, D., & Liu, Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27344 · Cited by 17 · see citing works
Retracted
11 Long noncoding RNA UCA1 functions as miR‐135a sponge to promote the epithelial to mesenchymal transition in glioma
Li, Z., Xiang, W., Shui, S., Han, X., Guo, D., & Lei, Y. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29467 · Cited by 16 · see citing works
LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2
Jiang, X., & Chen, D. (2020) · Aging · doi:10.18632/aging.103391 · Cited by 13 · see citing works
Non-coding RNAs enhance the apoptosis efficacy of therapeutic agents used for the treatment of glioblastoma multiform
Ghaemi, S., Fekrirad, Z., Zamani, N., Rahmani, R., & Arefian, E. (2022) · Journal of drug targeting · doi:10.1080/1061186x.2022.2047191 · Cited by 13 · see citing works
Competing endogenous RNAs regulatory crosstalk networks: The messages from the RNA world to signaling pathways directing cancer stem cell development
Aria, H., Azizi, M., Nazem, S., Mansoori, B., Darbeheshti, F., Niazmand, A., Daraei, A., & Mansoori, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35208 · Cited by 12 · see citing works
Retracted Article: SNHG3 promotes proliferation and invasion by regulating the miR-101/ZEB1 axis in breast cancer
Chang, L., Hu, Z., Zhou, Z., & Zhang, H. (2018) · RSC Advances · doi:10.1039/c8ra02090f · Cited by 11 · see citing works
Retracted
Identification of TNFAIP6 as a hub gene associated with the progression of glioblastoma by weighted gene co‐expression network analysis
Lin, D., Li, W., Zhang, N., & Cai, M. M. (2022) · IET Systems Biology · doi:10.1049/syb2.12046 · Cited by 11 · see citing works
SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis
Du, F., & Hou, Q. (2020) · BMC Cancer · doi:10.1186/s12885-020-07280-8 · Cited by 11 · see citing works
Long noncoding RNA UCA1 as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis
Liu, C., Jin, J., Shi, J. F., Wang, L., Gao, Z., Guo, T., & He, Y. (2019) · Bioscience Reports · doi:10.1042/bsr20180995 · Cited by 10 · see citing works
Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p
Sun, Y., Shen, Y., & Li, X. (2021) · Bioengineered · doi:10.1080/21655979.2021.1995573 · Cited by 9 · see citing works
Retracted
Long non-coding RNA TP73-AS1 contributes to glioma tumorigenesis by sponging the miR-103a/GALNT7 pathway
Wang, J., Chen, X.-L., Han, Z., Wang, H., Wang, Z.-H., Li, N.-N., & Lin, Z. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146886 · Cited by 9 · see citing works
FAM87A as a Competing Endogenous RNA of miR-424-5p Suppresses Glioma Progression by Regulating PPM1H
Xu, H., Zhang, H., Tan, L., Yang, Y., Wang, H., Zhao, Q., & Lu, J. (2021) · Computational and Mathematical Methods in Medicine · doi:10.1155/2021/7952922 · Cited by 8 · see citing works
Retracted
The Long Intergenic Noncoding RNA 00707 Sponges MicroRNA-613 (miR-613) to Promote Proliferation and Invasion of Gliomas
Liu, H., & Hu, K. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820962092 · Cited by 8 · see citing works
Knocking down LINC01116 can inhibit the regulation of TGF-β through miR-774-5p axis and inhibit the occurrence and development of glioma.
Lou, J., Wang, P., Chang, K., Wang, G., Geng, X., Wu, Y., Zhang, W., & Niu, G. (2021) · PubMed Central · Cited by 8 · see citing works
The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification
Schneider, B., William, D., Lamp, N., Zimpfer, A., Henker, C., Classen, C. F., & Erbersdobler, A. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04435-y · Cited by 8 · see citing works
miR‐129 targets CDK1 and iASPP to modulate Burkitt lymphoma cell proliferation in a TAp63‐dependent manner
Zou, H., Zou, R., Chen, K., Zhu, C., Tian, X., You, Y., & He, X. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27189 · Cited by 7 · see citing works
Molecular Pathological Markers Correlated With the Recurrence Patterns of Glioma
Ge, S., Shi, Y., Zhu, G., Li, S., Cai, Y., Ji, P., Liu, J., Guo, W., Gong, L., Lou, M., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.565045 · Cited by 6 · see citing works
Self-citation
Roles of long non-coding RNAs in the hallmarks of glioma.
Xue, B., Xiang, W., Zhang, Q., Wang, Y., Wang, H., Yi, D., Xiong, N., Jiang, X., Zhao, H., & Fu, P. (2020) · PubMed Central · doi:10.3892/ol.2020.11944 · Cited by 5 · see citing works
Self-citation
Particulate Matters Affecting lncRNA Dysregulation and Glioblastoma Invasiveness: In Silico Applications and Current Insights
Mukherjee, S., Kundu, U., Desai, D., & Pillai, P. P. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02069-9 · Cited by 3 · see citing works
MDA-TOEPGA: A novel method to identify miRNA-disease association based on two-objective evolutionary programming genetic algorithm
Cao, B., Luo, J., Xiao, S., & Zhou, X. (2022) · Biocell · doi:10.32604/biocell.2022.019613 · Cited by 3 · see citing works
The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis
Hooshmandi, S., Jangholi, E., Heidarian, A., Dehghani, M., Ghassemi, A., Heidary, A., Rezvanimehr, A., Sadeghi, E., Ghodsi, S. M., Hoseinian, M., et al. (2025) · Precision Medical Sciences · doi:10.1002/prm2.70003 · Cited by 1 · see citing works
LncRNA CAI2 Contributes to Poor Prognosis of Glioma through the PI3K-Akt Signaling Pathway
Jiang, Y., Zhang, J., Yu, S., Zheng, L., Shen, Y., Ju, W., & Lin, L. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207326666230519115845 · Cited by 1 · see citing works
Cancer Stem Cells and Competing Endogenous RNAsPreprint
Aria, H., Azizi, M., Nazem, S., Bahmanyar, M., Moravej, A., Pourjafarian, M. H., Pezeshki, B., Tavassoli, A., Vakil, M. K., & Mansoori, Y. (2022) · Preprints.org · doi:10.20944/preprints202207.0353.v1 · Cited by 1 · see citing works
LncRNA Interpreter: A Protein-Centric Pipeline for Mechanistic Analysis of Long Noncoding RNAsPreprint
Lin, X., Spindler, T. J., Fonseca, M. A. D. S., Corona, R. I., Seo, J.-H., Dezem, F. S., Li, L., Lee, J. M., Long, H. W., Sellers, T. A., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3271630
Curcumin affects the prognosis of renal cell carcinoma (RCC) through a negative feedback loop of H19/miR-675/HDAC/CTCF
Ni, W.-J., Liu, F., Yu, S., Li, F., Zhu, J., Chen, Z., Cheng, Y., & Li, C. (2021) · Archives of Medical Science · doi:10.5114/aoms/118940
Non-coding RNAs in glioblastoma at a glance
Basso, J., Fortuna, A. C., Vitorino, R. M. P., Akimitsu, N., & Vitorino, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99873-4.00028-1
The Future Prospects in Effective Management of Glioblastoma Multiforme Using Exosomes: A Comprehensive Review
Bhaskaran, M., Surabhi, C., Nesamony, J., & Selvam, C. (2024) · Springer eBooks · doi:10.1007/978-981-19-3949-5_34-1
The Future Prospects in Effective Management of Glioblastoma Multiforme Using Exosomes: A Comprehensive Review
Bhaskaran, M., Surabhi, C., Nesamony, J., & Selvam, C. (2024) · Springer eBooks · doi:10.1007/978-981-99-7557-0_34
The Role of Noncoding RNA in MGMT ‐Positive Glioblastoma: A Narrative Review
Zhao, J., Chen, J., Bai, Y., Li, Y., Han, Y., Han, C., & Li, Y. (2026) · Cancer Medicine · doi:10.1002/cam4.72362

A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma
Zhao, W., Sun, C., & Cui, Z. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-016-1597-7 · Cited by 48 · see citing works
11 Long noncoding RNA UCA1 functions as miR‐135a sponge to promote the epithelial to mesenchymal transition in glioma
Li, Z., Xiang, W., Shui, S., Han, X., Guo, D., & Lei, Y. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29467 · Cited by 16 · see citing works
LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1
Liang, C., Yang, Y., Guan, J., Lv, T., Qu, S., Fu, Q., & Zhao, H. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.07.036 · Cited by 50 · see citing works
The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/β-catenin signaling pathway
Zhang, B., Fang, S., Cheng, Y., Zhou, C., & Deng, F. (2019) · Aging · doi:10.18632/aging.102317 · Cited by 18 · see citing works
lncRNA CCAT1 Promotes Glioma Tumorigenesis by Sponging miR‐181b
Cui, B., Li, B., Liu, Q., & Cui, Y. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26116 · Cited by 99 · see citing works

Authors: He, Z., Wang, Y., Huang, G., Wang, Q., Zhao, D., & Chen, L.
Affiliations: University of Electronic Science and Technology of China (CN)
Kailuan General Hospital (CN)
Corresponding author: Zhao, Dongdong
Chen, Longyi
ORCID: He, Zongze
Wang, Yujue
Wang, Qi
Zhao, Dongdong
Chen, Longyi
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2017-06
Volume: 623-624
Pages: 1-8
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2017.01.013
OpenAlex: W2580761780
Cited by: 83
References: 43
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 15 · 2018: 21 · 2017: 8
FWCI: 4.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Funders: Sichuan Provincial Health Department Research Projects (130203)
Youth fund of Sichuan Provincial People's Hospital (2015QN18)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Keywords: UCA1, long non-coding RNA, miR-182, iASPP, glioma, cell proliferation, cell migration, metastasis, prognostic factors, therapeutic target, lncRNA-miRNA interaction
MeSH terms: Brain, Brain Neoplasms, Cell Movement, Female, Glioma, Humans, Male, Middle Aged, Repressor Proteins, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Cell Proliferation, RNA, Long Noncoding

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The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP

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