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Cited by 136Cancer-related molecular mechanisms researchGlioma Diagnosis and TreatmentMicroRNA in disease regulation

Non-coding RNAs in Glioma

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Rynkeviciene, Ryte, Simiene, Julija, Strainiene, Egle, Stankevicius, Vaidotas, Usinskiene, Jurgita, Miseikyte Kaubriene, Edita, Meskinyte, Ingrida, Cicenas, Jonas +1 more·2018·Cancers
DOI 10.3390/cancers11010017PMC PMC6356972
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Abstract

Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma. Numerous studies indicate that non-coding RNA species have critical functions across biological processes that regulate glioma initiation and progression. Recently, new data emerged, which shows that the cross-regulation between long non-coding RNAs and small non-coding RNAs contribute to phenotypic diversity of glioblastoma subclasses. In this paper, we review data of long non-coding RNA expression, which was evaluated in human glioma tissue samples during a five-year period. Thus, this review summarizes the following: (I) the role of non-coding RNAs in glioblastoma pathogenesis, (II) the potential application of non-coding RNA species in glioma-grading, (III) crosstalk between lncRNAs and miRNAs (IV) future perspectives of non-coding RNAs as biomarkers for glioma.

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  • In meningioma samples, members of the SNORD115 cluster have not been identified as up-regulated, supporting their exclusive neuronal origin.

    “Interestingly, in meningioma samples – members of SNORD115 cluster have not been identified as up-regulated, supporting their exclusive neuronal origin (Jha et al., 2015; Rynkeviciene et al., 2018).”

    From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Rynkeviciene et al., 2018

    The Discussion (page unavailable) describes snoRNA expression in pediatric gliomas, not meningioma samples. Searches for SNORD115, meningioma up-regulation, and neuronal origin found no passage addressing the attributed claim in our copy. (LLM, conf=0.73)

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Authors
Rynkeviciene, R., Simiene, J., Strainiene, E., Stankevicius, V., Usinskiene, J., Miseikyte Kaubriene, E., Meskinyte, I., Cicenas, J., & Suziedelis, K.
Affiliations
  • National Cancer Institute (LT)
  • Nacional Cancer Institute, Santariskiu str. 1, LT-08660 Vilnius, Lithuania
  • Vilnius University (LT)
ORCID
Venue
Cancers
Publisher
MDPI AG
Published
2018-12-22
Volume
11
Issue
1
Pages
17
ISSN
2072-6694 (ISSN-L)
DOI
10.3390/cancers11010017
PMC
PMC6356972
OpenAlex
W2906376872
Cited by
136
References
6
Citations by year
2026: 3 · 2025: 5 · 2024: 26 · 2023: 9 · 2022: 14 · 2021: 30 · 2020: 34 · 2019: 15
FWCI
2.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancers (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Research Council of Lithuania (MIP-015/2014)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords
non-coding RNA, glioma, glioblastoma, long non-coding RNA, microRNA, glioma grading, biomarkers, tumor heterogeneity, tumor invasion, tumor progression

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