CoChat
Sign Up
Cited by 151Multiple Sclerosis Research StudiesCancer survivorship and careFibromyalgia and Chronic Fatigue Syndrome Research

An examination of four models predicting fatigue in multiple sclerosis

STROBER, L, ARNETT, P·2005·Archives of Clinical Neuropsychology
DOI 10.1016/j.acn.2005.04.002
Open this paper in CoChat — free account

Abstract

Fatigue is a common symptom of multiple sclerosis (MS) that is purported to cause significant distress and have detrimental effects on daily functioning, social and occupational obligations, and overall well-being. The prevalence of fatigue in MS is high, with 53-87% of patients reporting significant problems with fatigue across different studies reported in the literature. The cause of fatigue in MS is still poorly understood. Some researchers have suggested that fatigue is a direct consequence of the MS disease process, but several studies have failed to find a relationship between disease severity and MS fatigue. A number of investigations have reported that depression and sleep are significantly related to fatigue in MS, as well as to one another. The purpose of the present investigation was to examine the relationships among disease severity, depression, and sleep disturbance in MS, and their possible role in predicting fatigue. Four models were proposed to explore these relationships. The best fitting model showed that all three were significant independent contributors to fatigue in MS, accounting for 43% of the variance, with sleep disturbance reigning as the largest contributor. Furthermore, although disease severity predicted fatigue in our sample, both depression and sleep disturbance emerged as stronger predictors. These findings suggest that, beyond core physical/neurological MS symptomatology, there are other factors that contribute to fatigue in MS, namely, dep…

Integrity signals

Registry

Crossref · 10.1016/j.acn.2005.04.002

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
STROBER, L., & ARNETT, P.
Affiliations
Pennsylvania State University (US)
Corresponding author
ARNETT, P
ORCID
Venue
Archives of Clinical Neuropsychology
Publisher
Oxford University Press (OUP)
Published
2005-07
Volume
20
Issue
5
Pages
631-646
ISSN
0887-6177 (ISSN-L)
DOI
10.1016/j.acn.2005.04.002
OpenAlex
W2101442960
Cited by
151
References
4
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 6 · 2016: 18 · 2015: 9 · 2014: 2 · 2013: 7 · 2012: 7
FWCI
5.61
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Clinical Neuropsychology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
multiple sclerosis, fatigue, depression, sleep disorders, disease severity, predictors of fatigue
MeSH terms
Adult, Aged, Depression, Fatigue, Female, Humans, Male, Middle Aged, Models, Theoretical, Multiple Sclerosis, Prognosis, Severity of Illness Index, Sleep Wake Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review