Cited by 58Mindfulness and Compassion InterventionsMultiple Sclerosis Research StudiesCancer survivorship and care

Mindfulness-based cognitive therapy for severely fatigued multiple sclerosis patients: A waiting list controlled study

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Hoogerwerf, A, Bol, Y, Lobbestael, J, Hupperts, R, Heugten, C·2017·Journal of Rehabilitation Medicine

Abstract

BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce. OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients. METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue. PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months). RESULTS: Adherence rate was 71%. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46% showed a clinically relevant change regarding fatigue. CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.

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  1. [4]4. Dittner AJ, Wessely SC, Brown RG. The assessment of fatigue: a practical guide for clinicians and researchers. J Psychosom Res 2004; 56: 157-170.
  2. [9]9. Ponds R, Van Boxtel M, Jolles J. [De cognitive failures ques- tionnaire.] Tijdschr Neuropsychol 2006; 1: 37-42. (in Dutch).
  3. [21]21. Kabat-Zinn J. Full Catasprophe living (revised edition): using the wisdom of your body and mind to face stress, pain, and illness. New York: Random House Publishing Group; 2013.
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  6. [35]35. Ludwig DS, Kabat-Zinn J. Mindfulness in medicine. JAMA 2008; 300: 1350-1352.
  7. [37]37. Grossman P, Kappos L, Gensicke H, d'Souza M, Mohr DC, Penner IK, et al. MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial. Neurology 2010; 75: 1141-1149.

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Authors
Hoogerwerf, A., Bol, Y., Lobbestael, J., Hupperts, R., & Heugten, C.
Affiliations
  • Zuyderland Medisch Centrum (NL)
  • Maastricht University (NL)
Venue
Journal of Rehabilitation Medicine
Published
2017
Volume
49
Issue
6
Pages
497-504
ISSN
1650-1977 (ISSN-L)
OpenAlex
W2623025629
Cited by
58
References
30
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 28 · 2018: 5 · 2016: 1
FWCI
11.84
Type
journal article
Language
en
Open access
Locations
  • Journal of Rehabilitation Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by-nc)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords
mindfulness-based cognitive therapy, multiple sclerosis, fatigue, feasibility, fatigue severity, anxiety, depression, sleep, cognitive failure, coping, mindfulness, psychological well-being
MeSH terms
Adolescent, Adult, Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Pilot Projects, Waiting Lists, Cognitive Behavioral Therapy, Young Adult, Mindfulness

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