Mindfulness-based cognitive therapy for severely fatigued multiple sclerosis patients: A waiting list controlled study
Open accessAbstract
BACKGROUND: Fatigue is the most common symptom in multiple sclerosis. Evidence-based treatment options are scarce. OBJECTIVE: To study the feasibility and potential effectiveness of mindfulness-based cognitive therapy in severely fatigued multiple sclerosis patients. METHODS: Non-randomized pilot study with a wai-ting list control period including 59 multiple sclerosis patients with severe fatigue. PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist Individual Strength-20. Secondary measures: Hospital Anxiety and Depression Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale, Coping Inventory of Stressful Situations, and Five Facet Mindfulness Questionnaire-Short Form. Measurements were taken before treatment (double baseline), after treatment, and at follow-up (3 months). RESULTS: Adherence rate was 71%. Eight out of 10 participants who completed the intervention were satisfied with the intervention. Significant time effects were found for 7 out of 11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all outcome measures that were significant post-treatment and/or at follow-up (Ƞ² = 0.10-0.17). Improvements were maintained at follow-up. Of the completers, 46% showed a clinically relevant change regarding fatigue. CONCLUSION: Mindfulness-based cognitive therapy is feasible in severely fatigued multiple sclerosis patients and has positive results in the reduction of severe fatigue and several psychological factors.
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In neurological conditions like multiple sclerosis, mindfulness-based interventions have shown improvements in anxiety, depression, fatigue, and stress.
“MBIs have also been studied in neurological diseases such as multiple sclerosis, demonstrating improvement in anxiety, depression, fatigue, and stress levels (Ghielen et al., 2019; Hoogerwerf et al., 2017; Simpson et al., 2019).”
From Online Mindfulness-Based Cognitive Therapy for People with Parkinson’s Disease and Their Caregivers: a Pilot Study (2022) · cites this paper as Hoogerwerf et al., 2017
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- Authors
- Hoogerwerf, A., Bol, Y., Lobbestael, J., Hupperts, R., & Heugten, C.
- Affiliations
- Zuyderland Medisch Centrum (NL)
- Maastricht University (NL)
- Venue
- Journal of Rehabilitation Medicine
- Published
- 2017
- Volume
- 49
- Issue
- 6
- Pages
- 497-504
- ISSN
- 1650-1977 (ISSN-L)
- OpenAlex
- W2623025629
- Cited by
- 58
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 28 · 2018: 5 · 2016: 1
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Rehabilitation Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by-nc)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- mindfulness-based cognitive therapy, multiple sclerosis, fatigue, feasibility, fatigue severity, anxiety, depression, sleep, cognitive failure, coping, mindfulness, psychological well-being
- MeSH terms
- Adolescent, Adult, Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Pilot Projects, Waiting Lists, Cognitive Behavioral Therapy, Young Adult, Mindfulness
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