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Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs)
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OBJECTIVE: Executive functioning has been repeatedly linked to the integrity of instrumental activities of daily living (IADL). The present study examined the association of multiple executive functioning elements (i.e., working memory, generation, inhibition, planning, and sequencing) to IADLs among an older adult cohort at risk for future cognitive and functional decline. METHODS: Seventy-two participants with prevalent but stable cardiovascular disease completed a neuropsychological protocol assessing multiple elements of executive functioning, including COWA, PASAT, DKEFS Color-Word Interference Test, DKEFS Trail-Making Test, DKEFS Tower Test, and Ruff Figural Fluency Test. Reliable informants completed a measure of IADLs. RESULTS: Stepwise logistic regression selected a model involving a single significant predictor, a measure of inhibition (i.e., DKEFS Color-Word Interference Test), which had a significant regression coefficient. Subsequent correlation analyses confirmed an association between the inhibition measure and multiple IADL items. Inter-item comparisons among the IADLs revealed significant differences, such that telephone use and laundry were significantly more intact than most other IADLs while shopping and housekeeping were most compromised. CONCLUSIONS: Our data suggest that inhibition, also known as susceptibility to interference, is most strongly related to IADL impairment among patients at risk for future cognitive and functional decline.
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“although our measure of executive functioning (DKEFS Inhibition) is commonly used to measure this NP domain,22,48”
From Neuropsychological Functioning and Treatment Outcomes in Acceptance and Commitment Therapy for Chronic Pain. (2018) · cites this paper as [22]
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Metadata
- Authors
- JEFFERSON, A., PAUL, R., OZONOFF, A., & COHEN, R.
- Affiliations
- Boston University (US)
- Brown University (US)
- Corresponding author
- JEFFERSON, A
- Venue
- Archives of Clinical Neuropsychology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05
- Volume
- 21
- Issue
- 4
- Pages
- 311-320
- ISSN
- 0887-6177 (ISSN-L)
- PMC
- PMC2746400
- OpenAlex
- W1998561429
- Cited by
- 248
- References
- 41
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 8 · 2023: 17 · 2022: 12 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 11 · 2017: 11 · 2016: 21 · 2015: 9 · 2014: 14 · 2013: 17 · 2012: 11
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Clinical Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k12hd043444-10)
- National Institute on Aging (AG017975, AG022773, AG013846, P30AG013846, R01AG017975, F32AG022773)
- National Institute of Mental Health (K23MH065857, MH065857)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD043444, HD043444)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- executive function, instrumental activities of daily living, inhibition, working memory, planning, sequencing, older adults, cardiovascular disease, cognitive decline, functional decline, Color-Word Interference Test, activities of daily living
- MeSH terms
- Activities of Daily Living, Aged, Cardiovascular Diseases, Disability Evaluation, Female, Humans, Inhibition, Psychological, Male, Memory, Short-Term, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Problem Solving, Residence Characteristics, Risk, Sampling Studies, Geriatric Assessment, Logistic Models
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