The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Gradient collagen/nanohydroxyapatite composite scaffold: Development and characterization
Open accessAbstract
This paper reports an in situ diffusion method for the fabrication of compositionally graded collagen/nanohydroxyapatite (HA) composite scaffold. The method is diffusion based and causes the precipitation of nano-HA crystallites in situ. A collagen matrix acts as a template through which calcium ions (Ca(2+)) and phosphate ions (PO4(3-)) diffuse and precipitate a non-stoichiometric HA. It was observed that needle-like prismatic nano-HA crystallites (about 2 x 2 x 20 nm) precipitated in the interior of the collagen template onto the collagen fibrils. Chemical and microstructural analysis revealed a gradient of the Ca to P ratio across the width of the scaffold template, resulting in the formation of a Ca-rich side and a Ca-depleted side of scaffold. The Ca-rich side featured low porosity and agglomerates of the nano-HA crystallites, while the Ca-depleted side featured higher porosity and nano-HA crystallites integrated with collagen fibrils to form a porous network structure.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A Ca-rich scaffold with interconnected porous structure was developed which facilitates cell attachment and proliferation.[111]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [111]
Citations
Cites
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639
Porous scaffold design for tissue engineering
Hollister, S. J. (2005) · Nature Materials · doi:10.1038/nmat1421 · Cited by 3,979
Phenomenological Theory of Ion Solvation. Effective Radii of Hydrated Ions
Nightingale, E. R. (1959) · The Journal of Physical Chemistry · doi:10.1021/j150579a011 · Cited by 3,505
Synthesis and characterization of hydroxyapatite crystals: A review study on the analytical methods
Koutsopoulos, S. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10280 · Cited by 1,663
Polymeric Scaffolds for Bone Tissue Engineering
Liu, X., & Ma, P. X. (2004) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000017544.36001.8e · Cited by 1,368
The effect of pore size on cell adhesion in collagen-GAG scaffolds
O’Brien, F. J., Harley, B. A. C., Yannas, I. V., & Gibson, L. J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.052 · Cited by 1,336
Scaffolds for tissue fabrication
Ma, P. X. (2004) · Materials Today · doi:10.1016/s1369-7021(04)00233-0 · Cited by 1,108
The direct examination of three-dimensional bone architecture in vitro by computed tomography
Feldkamp, L. A., Goldstein, S. A., Parfitt, M. A., Jesion, G., & Kleerekoper, M. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040103 · Cited by 1,073
Oh, S. H., Park, I. K., Kim, J., & Lee, J. H. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.024 · Cited by 720
Cellular materials as porous scaffolds for tissue engineering
Freyman, T. M., Yannas, I. V., & Gibson, L. J. (2001) · Progress in Materials Science · doi:10.1016/s0079-6425(00)00018-9 · Cited by 586
FT-IR study for hydroxyapatite/collagen nanocomposite cross-linked by glutaraldehyde
Chang, M. C., & Tanaka, J. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00232-6 · Cited by 560
Kushida, A., Yamato, M., Konno, C., Kikuchi, A., Sakurai, Y., & Okano, T. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990615)45:4 · Cited by 495
Compressive and shear properties of alginate gel: Effects of sodium ions and alginate concentration
LeRoux, M. A., Guilak, F., & Setton, L. A. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199910)47:1 · Cited by 449
Chitosan scaffolds: Interconnective pore size and cartilage engineering
Griffon, D. J., Sedighi, M. R., Schaeffer, D. J., Eurell, J. A. C., & Johnson, A. (2006) · Acta Biomaterialia · doi:10.1016/j.actbio.2005.12.007 · Cited by 352
Novel collagen scaffolds with predefined internal morphology made by solid freeform fabrication
Sachlos, E. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00528-8 · Cited by 350
Engineering functionally graded tissue engineering scaffolds
Leong, K. F., Chua, C. K., Sudarmadji, N., & Yeong, W. Y. (2007) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2007.11.002 · Cited by 346
Biomaterials, artificial organs and tissue engineering
Hench, L. L., & Jones, J. R. (2005) · Woodhead Publishing Limited eBooks · doi:10.1533/9781845690861 · Cited by 310
Kikuchi, M., Ikoma, T., Itoh, S., Matsumoto, H., Koyama, Y., Takakuda, K., Shinomiya, K., & Tanaka, J. (2003) · Composites Science and Technology · doi:10.1016/j.compscitech.2003.09.002 · Cited by 279
In vitro generation of osteochondral composites
Schaefer, D. J., Martín, I., Shastri, P. V., Padera, R. F., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00127-7 · Cited by 261
Martin, R. B., & Boardman, D. L. (1993) · Journal of Biomechanics · doi:10.1016/s0021-9290(05)80004-1 · Cited by 250
Interactions of 3T3 fibroblasts and endothelial cells with defined pore features
Salem, A. K., Stevens, R., Pearson, R. G., Davies, M. C., Tendler, S. J. B., Roberts, C. J., Williams, P. M., & Shakesheff, K. M. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10195 · Cited by 229
Mechanical Properties of Dried Defatted Spongy Bone
Lindahl, O. (1976) · Acta Orthopaedica Scandinavica · doi:10.3109/17453677608998966 · Cited by 194
Controlling the processing of collagen-hydroxyapatite scaffolds for bone tissue engineering
Wahl, D. A., Sachlos, E., Liu, C., & Czernuszka, J. T. (2007) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-006-0682-9 · Cited by 170
Self-citationSachlos, E., Gotora, D., & Czernuszka, J. T. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.2479 · Cited by 152
Self-citationBiologically inspired growth of hydroxyapatite nanocrystals inside self-assembled collagen fibers
Roveri, N., Falini, G., Sidoti, M. C., Tampieri, A., Landi, E., Sandri, M., & Parma, B. (2003) · Materials Science and Engineering C · doi:10.1016/s0928-4931(02)00318-1 · Cited by 137
Chang, M. C., & Tanaka, J. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00133-3 · Cited by 137
Hydroxyapatite/collagen composite materials formation in simulated body fluid environment
Zhang, L., Feng, X.-S., Liu, H.-G., Qian, D., Zhang, L., Yu, X., & Cui, F. (2003) · Materials Letters · doi:10.1016/j.matlet.2003.07.009 · Cited by 126
Novel 3D collagen scaffolds fabricated by indirect printing technique for tissue engineering
Liu, C., Xia, Z., Han, Z., Hulley, P. A., Triffitt, J. T., & Czernuszka, J. T. (2007) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30975 · Cited by 117
Self-citationCollagen-calcium phosphate composites
Lawson, A. C., & Czernuszka, J. T. (1998) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1243/0954411981534187 · Cited by 112
Self-citationIntroduction to the biomechanics of joints and joint replacement
Dumbleton, J. H. (1981) · Tribology International · doi:10.1016/0301-679x(81)90136-5 · Cited by 104
Persidis, A. (1999) · Nature Biotechnology · doi:10.1038/8700 · Cited by 100
Yaylaoglu, M., Yıldız, C., Korkusuz, F., & Hasırcı, V. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00062-9 · Cited by 93
Preferred growth orientation of biomimetic apatite crystals
Müller, F. A., Müller, L., Caillard, D., & Conforto, E. (2007) · Journal of Crystal Growth · doi:10.1016/j.jcrysgro.2007.03.014 · Cited by 86
Development of biodegradable scaffolds for tissue engineering: A perspective on emerging technology
Liu, C., & Czernuszka, J. T. (2007) · Materials Science and Technology · doi:10.1179/174328407x177027 · Cited by 81
Self-citationFormation of nano-hydroxyapatite on recombinant human-like collagen fibrils
Zhai, Y., Cui, F. Z., & Wang, Y. (2005) · Current Applied Physics · doi:10.1016/j.cap.2005.01.004 · Cited by 68
Preparation and Characterization of a Multilayer Biomimetic Scaffold for Bone Tissue Engineering
Kong, L., Ao, Q., Wang, A., Gong, K., Wang, X., Lu, G., Gong, Y., Zhao, N., & Zhang, X. (2007) · Journal of Biomaterials Applications · doi:10.1177/0885328206073706 · Cited by 65
Apatite coating on anionic and native collagen films by an alternate soaking process
Góes, J. C., Figueiró, S. D., Oliveira, A. M., Macêdo, A. A. M., Silva, C. C., Ricardo, N. M. P. S., & Sombra, A. S. B. (2007) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.02.008 · Cited by 61
A fractographic study of human long bone
Corondan, G., & Haworth, W. L. (1986) · Journal of Biomechanics · doi:10.1016/0021-9290(86)90153-3 · Cited by 52
Constructal view of electrokinetic transfer through porous media
Lorente, S. (2007) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/40/9/041 · Cited by 46
Hu, K., Yang, X., Cai, Y.-L., Cui, Z., & Wei, Q. (2006) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2006.02.036 · Cited by 34
Calcium phosphate precipitation in the 60–80°C range
Freche, M., & Heughebaert, J. C. (1989) · Journal of Crystal Growth · doi:10.1016/0022-0248(89)90128-0 · Cited by 29
An Introduction to the Biomechanics of Joints and Joint Replacement
Gardner, D. L. (1982) · Annals of the Rheumatic Diseases · doi:10.1136/ard.41.4.439-c · Cited by 18
Transformation behaviour of calcium phosphate 2. Effects of various phosphorylated amino acids
Wong, A. T.-C., & Czernuszka, J. T. (1995) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/0927-7757(95)03216-z · Cited by 11
Self-citationStructure-Function Relationships for a Coralline Hydroxyapatite Bone Substitute
Haddock, S. M., Debes, J. C., & Keaveny, T. M. (1998) · Advances in Bioengineering · doi:10.1115/imece1998-0163 · Cited by 2
Flagged first, then by citations
1 of the 45 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Sah, 2004, Repair, regeneration, and replacement of articular cartilage, Osteoarthritis Cartilage, 12, S28
- Lawson AC. Collagen–calcium phosphate composite. D. Phil. thesis, University of Oxford; 1998.
- Gotora D. Pre-cross-linked collagen-hydroxyapatite composites. D. Phil. thesis, University of Oxford; 2005.
Cited by
Sorted by citations
Conductive Polymers: Opportunities and Challenges in Biomedical Applications
Nezakati, T., Seifalian, A., Tan, A., & Seifalian, A. M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00275 · Cited by 1,010
Engineering biocompatible implant surfaces
Bauer, S., Schmuki, P., von der Mark, K., & Park, J. (2012) · Progress in Materials Science · doi:10.1016/j.pmatsci.2012.09.001 · Cited by 795
Duan, B., Wang, M., Zhou, W. Y., Cheung, W. L., Li, Z. Y., & Lu, W. W. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.06.024 · Cited by 421
“Nanosized osteoconductive calcium phosphates (Ca-Ps), including HA, tricalcium phosphate (TCP) and substituted HA and TCP, have gained much recognition in biomaterials development because of their small size, high surface area to volume ratio and biomimetic similarity to natural bone structure when combined with biopo…”
BackgroundGradient biomaterials for soft-to-hard interface tissue engineering
Seidi, A., Ramalingam, M., Elloumi-Hannachi, I., Ostrovidov, S., & Khademhosseini, A. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.01.011 · Cited by 400
“Table 2 [30–32,40–46] summarizes the most commonly used methods to generate gradient biomaterials.”
Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix
von der Mark, K., Park, J., Bauer, S., & Schmuki, P. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0896-5 · Cited by 347
“…Tiitu et al. 2008), frequently also being employed as composite scaffolds by including hydroxyapatite (Al-Munajjed et al. 2009; Keeney et al. 2009; Liu et al. 2009a), fibrin (Malicev et al. 2007), HA (Liao et al. 2007; Tang and Spector 2007), or synthetic polymers such as…”
BackgroundMethod
Metadata
- Authors
- Liu, C., Han, Z., & Czernuszka, J. T.
- Affiliations
- University of Oxford (GB)
- Jilin University (CN)
- Corresponding author
- Liu, Chaozong
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 5
- Issue
- 2
- Pages
- 661-669
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2059421614
- Cited by
- 109
- References
- 45
- Citations by year
- 2024: 3 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 16
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust (074486)
- University of Oxford
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- gradient scaffolds, calcium phosphate precipitation, collagen fibrils, porous scaffolds, scaffold porosity
- MeSH terms
- Animals, Cattle, Collagen, Hydrogen-Ion Concentration, Spectrum Analysis, Tomography, X-Ray Computed, X-Rays, Durapatite, Microscopy, Electron, Transmission, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
