Cited by 109Bone Tissue Engineering MaterialsCollagen: Extraction and CharacterizationElectrospun Nanofibers in Biomedical Applications

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Gradient collagen/nanohydroxyapatite composite scaffold: Development and characterization

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Liu, Chaozong, Han, Zhiwu, Czernuszka, J.T.·2009·Acta Biomaterialia

DOI 10.1016/j.actbio.2008.09.022

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Abstract

This paper reports an in situ diffusion method for the fabrication of compositionally graded collagen/nanohydroxyapatite (HA) composite scaffold. The method is diffusion based and causes the precipitation of nano-HA crystallites in situ. A collagen matrix acts as a template through which calcium ions (Ca(2+)) and phosphate ions (PO4(3-)) diffuse and precipitate a non-stoichiometric HA. It was observed that needle-like prismatic nano-HA crystallites (about 2 x 2 x 20 nm) precipitated in the interior of the collagen template onto the collagen fibrils. Chemical and microstructural analysis revealed a gradient of the Ca to P ratio across the width of the scaffold template, resulting in the formation of a Ca-rich side and a Ca-depleted side of scaffold. The Ca-rich side featured low porosity and agglomerates of the nano-HA crystallites, while the Ca-depleted side featured higher porosity and nano-HA crystallites integrated with collagen fibrils to form a porous network structure.

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“Hydroxyapatite (HAp), a nanoparticle extensively investigated in the context of orthopedic grafts (Liu et al., 2009; Zandi et al., 2010; Ravichandran et al., 2012), is the prevailing subject of study in relation to bone regeneration.”
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Collagen scaffolds with in situ-grown calcium phosphate for osteogenic differentiation of Wharton's jelly and menstrual blood stem cells
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“The pore sizes of the foams used for cell seeding in this study were around 200 mm, and Liu et al. (2009) reported that large pores support the transport of nutrients and removal of wastes, but also cause low attachment efficiency and intracellular signalling.”
An update on hydroxyapatite/collagen composites: What is there left to say about these bioinspired materials?
Veiga, A., Castro, F., Rocha, F. A., & Oliveira, A. L. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34976 · Cited by 24
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Chemical and morphological gradient scaffolds to mimic hierarchically complex tissues: From theoretical modeling to their fabrication
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“…scaffolds providing appropriate chemical and physical (such as porosity, stiffness, and topology) cues can build up a microenvironment, the so-called niche, which may trigger a selective cellular differentiation and matrix formation (Liu et al., 2009; Pennesi et al., 2011; Scaglione et al., 2011).”
Background
Electrolytic Deposition of Collagen/HA Composite on Post HA∕TiO[sub 2] Coated Ti6Al4V Implant Alloy
Yang, C.-C., Huang, C.-Y., Lin, C.-C., & Yen, S. (2010) · Journal of The Electrochemical Society · doi:10.1149/1.3525604 · Cited by 17
Supplementation of collagen scaffolds with SPARC to facilitate mineralization
Pataquiva-Mateus, A., Wu, H., Lucchesi, C., Ferraz, M. P., Monteiro, F. J., & Spector, M. (2012) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.32650 · Cited by 16
Synthesis of ultralong hydroxyapatite micro/nanoribbons and their application as reinforcement in collagen scaffolds for bone regeneration
Ying, R.-L., Sun, R., Li, Q., Fu, C.-N., & Chen, K. (2018) · Ceramics International · doi:10.1016/j.ceramint.2018.12.059 · Cited by 16
Mineralization of Collagen‐Coated Electrospun Poly(lactide‐co‐glycolide) Nanofibrous Mesh to Enhance Growth and Differentiation of Osteoblasts and Bone Marrow Mesenchymal Stem Cells
Lao, L., Zhu, Y., Zhang, Y., Gao, Z., Zhou, F., Chen, L., Ouyang, H., & Gao, C. (2011) · Advanced Engineering Materials · doi:10.1002/adem.201180023 · Cited by 16
Facile fabrication of Luffa cylindrica-assisted 3D hydroxyapatite scaffolds
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Decellularized dermis–polymer complex provides a platform for soft-to-hard tissue interfaces
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A facile approach to construct three-dimensional oriented chitosan scaffolds with in-situ precipitation method
Li, Y., Wang, Y., Wu, D. X., Zhang, K., & Hu, Q. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.11.042 · Cited by 15
Collagen-Chondroitin Sulphate-Hydroxyapatite Porous Composites: A Histochemical and Electron Microscopy Approach
Zărnescu, O., Crăciunescu, O., & Moldovan, L. (2010) · Microscopy and Microanalysis · doi:10.1017/s1431927609991346 · Cited by 15
“…with an adequate amount of carbonate substitution ~Murugan & Ramakrishna, 2005!. Scaffolds based on inorganic and organic substances such as hydroxyapatite and collagen have been constructed ~Zhang et al., 2003; Kikuchi et al., 2004; Kamakura et al., 2007; Yunoki et al., 2007; Liu et al., 2009!.”
Background
Stabilizing effect of carbodiimide and dehydrothermal treatment crosslinking on the properties of collagen/hydroxyapatite scaffolds
Kozłowska, J., Sionkowska, A., Osyczka, A. M., & Dubiel, M. (2017) · Polymer International · doi:10.1002/pi.5371 · Cited by 14
Enhance stability and in vitro cell response to a bioinspired coating on zr alloy with increasing chitosan content
Ioniță, D., Vardaki, M., Stan, M. S., Dinischiotu, A., & Demetrescu, I. (2017) · Journal of Bionic Engineering · doi:10.1016/s1672-6529(16)60411-0 · Cited by 13
Integrated approach in designing biphasic nanocomposite collagen/nBCP scaffolds with controlled porosity and permeability for bone tissue engineering
Ebrahimi, M., Botelho, M. G., Lu, W. W., & Monmaturapoj, N. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34518 · Cited by 12
Micro‐ and Nanoengineering Approaches to Developing Gradient Biomaterials Suitable for Interface Tissue Engineering
Ostrovidov, S., Seidi, A., Ahadian, S., Ramalingam, M., & Khademhosseini, A. (2013) · doi:10.1002/9781118574775.ch3 · Cited by 12
Toward chronopharmaceutical drug delivery patches and biomaterial coatings for the facilitation of wound healing
Uskoković, V., Velie, P. N., & Wu, V. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.12.156 · Cited by 11
Incorporation of Hydroxyapatite Sol Into Collagen Gel to Regulate the Contraction Mediated by Human Bone Marrow-Derived Stromal Cells
Liu, Y., & Williams, D. (2009) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2009.2034654 · Cited by 11
Nanoparticles for Dental Materials
Mitra, S. B. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-7862-1.00002-x · Cited by 11
Effect of gradient biomineral concentrations on osteogenic and chondrogenic differentiation of adipose derived stem cells
Perikamana, S. K. M., Lee, J., Park, S. Y., Jung, H. S., & Shin, H. (2019) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2019.06.037 · Cited by 11
Label-Free Characterization of Collagen Crosslinking in Bone-Engineered Materials Using Nonlinear Optical Microscopy
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“In summary, collagen-based materials have a variety of advantages, including (i) nontoxicity and biocompatibility, (ii) decomposability and absorbability by living organisms, (iii) various forms of a matrix with other biologically active molecules, (iv) hemostatic properties for blood clot formation, (v) biodegradatio…”
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Mineralization of fibers for bone regeneration
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Authors: Liu, C., Han, Z., & Czernuszka, J. T.
Affiliations: University of Oxford (GB)
Jilin University (CN)
Corresponding author: Liu, Chaozong
ORCID: Liu, Chaozong
Han, Zhiwu
Czernuszka, J.T.
Venue: Acta Biomaterialia
Publisher: Elsevier BV
Published: 2009-02
Volume: 5
Issue: 2
Pages: 661-669
ISSN: 1742-7061 (ISSN-L)
DOI: 10.1016/j.actbio.2008.09.022
OpenAlex: W2059421614
Cited by: 109
References: 45
Citations by year: 2024: 3 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 16
FWCI: 4.65
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Acta Biomaterialia (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust (074486)
University of Oxford
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: gradient scaffolds, calcium phosphate precipitation, collagen fibrils, porous scaffolds, scaffold porosity
MeSH terms: Animals, Cattle, Collagen, Hydrogen-Ion Concentration, Spectrum Analysis, Tomography, X-Ray Computed, X-Rays, Durapatite, Microscopy, Electron, Transmission, Nanoparticles

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Gradient collagen/nanohydroxyapatite composite scaffold: Development and characterization

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