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Cited by 175Bacterial biofilms and quorum sensingSurface Modification and SuperhydrophobicityPolymer Surface Interaction Studies

Submicron-textured biomaterial surface reduces staphylococcal bacterial adhesion and biofilm formation

Xu, Li-Chong, Siedlecki, Christopher A.·2012·Acta Biomaterialia
DOI 10.1016/j.actbio.2011.08.009
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Abstract

Staphylococci are among the most important pathogens causing bloodstream infections associated with implanted medical devices. Control of bacterial adhesion to material surfaces is important for prevention of biofilm formation and biomaterial-associated infections. In this study, we hypothesized that submicron (staphylococcal bacterial dimension) surface textures may reduce the bacterial adhesion via a decrease in surface area that bacteria can contact, and subsequently inhibit biofilm formation. Poly(urethane urea) films were textured with two different sizes of submicron pillars via a two-stage replication process. Adhesion of two bacterial strains (Staphylococcus epidermidis RP62A and S. aureus Newman) was assessed over a shear stress range of 0-13.2 dyn cm(-2) using a rotating disk system in physiological buffer solutions. Significant decreases in bacterial adhesion were observed on textured surfaces for both strains compared with smooth controls. Biofilm formation was further tested on surfaces incubated in solution for either 2 or 5 days and it was found that biofilm formation was dramatically inhibited on textured surfaces. The results of the approaches used in this work demonstrate that patterned surface texturing of biomaterials provides an effective means to reduce staphylococcal adhesion and biofilm formation on biomaterial surfaces, and thus to prevent biomaterial-associated infections.

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Crossref · 10.1016/j.actbio.2011.08.009

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  • Creating a submicron-textured surface can reduce accessible contact area for platelets and bacteria, minimizing adsorption opportunities.

    “Creating a submicron-textured surface can dramatically reduce the accessible contact area for platelets or bacteria to interact with the surface, thereby minimizing the opportunities for bacteria and platelet adsorption.102–104”

    From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [103]

  • For medical device applications, focus has been on antibacterial and antibiofilm properties, especially for bacteria that commonly cause CRBSIs, such as S. epidermidis, S. aureus, and P. aeruginosa.

    “However, for medical device applications, the focus has thus far been on its antibacterial/antibiofilm properties, especially for the bacteria that most commonly cause CRBSIs (catheter related bloodstream infections), such as Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), and Pseudomonas aeruginosa (P. aeruginosa).66,103”

    From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [103]

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Authors
Xu, L.-C., & Siedlecki, C. A.
Affiliations
Pennsylvania State University (US)
Corresponding author
Siedlecki, Christopher A.
ORCID
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2012-01
Volume
8
Issue
1
Pages
72-81
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2011.08.009
OpenAlex
W2046033766
Cited by
175
References
55
Citations by year
2026: 8 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 20 · 2014: 15 · 2013: 9 · 2012: 6
FWCI
3.88
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Acta Biomaterialia (publishedVersion)
  • PubMed (publishedVersion)
Funders
Penn State College of Medicine
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Surface Modification and Superhydrophobicity
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
biomaterial surface modification, bacterial adhesion, biofilm formation, Staphylococcus epidermidis, Staphylococcus aureus, pillar arrays, replication molding, shear stress, biomaterial-associated infection, implant surface design
MeSH terms
Bacterial Adhesion, Biocompatible Materials, Humans, Materials Testing, Polyurethanes, Staphylococcal Infections, Staphylococcus aureus, Staphylococcus epidermidis, Stress, Mechanical, Surface Properties, Biofilms

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