Novel Strategies for the Prevention and Treatment of Biofilm Related Infections
Open accessAbstract
Biofilm formation by human bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. As a result, novel therapeutic solutions other than the conventional antibiotic therapies are in urgent need. In this review, we will discuss the recent research in discovery of alternative approaches to prevent or treat biofilms. Current anti-biofilm technologies could be divided into two groups. The first group focuses on targeting the biofilm forming process of bacteria based on our understanding of the molecular mechanism of biofilm formation. Small molecules and enzymes have been developed to inhibit or disrupt biofilm formation. Another group of anti-biofilm technologies focuses on modifying the biomaterials used in medical devices to make them resistant to biofilm formation. While these novel anti-biofilm approaches are still in nascent phases of development, efforts devoted to these technologies could eventually lead to anti-biofilm therapies that are superior to the current antibiotic treatment.
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After planktonic bacteria colonize polymeric device surfaces, they grow into colonies and form hydrated EPS matrices known as biofilms.
“After planktonic bacteria initially colonize onto the surfaces of polymeric devices, cells start to grow into colonies, and then hydrated matrices of extracellular polymeric substances (EPS) are formed, also known as biofilms,16–18”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [16]
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- Authors
- Chen, M., Yu, Q., & Sun, H.
- Affiliations
- Nanova Biomaterials (United States) (US)
- University of Missouri (US)
- Corresponding author
- Sun, Hongmin
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-09-06
- Volume
- 14
- Issue
- 9
- Pages
- 18488-18501
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3794791
- OpenAlex
- W2084387253
- Cited by
- 429
- References
- 86
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 27 · 2023: 42 · 2022: 44 · 2021: 41 · 2020: 45 · 2019: 43 · 2018: 39 · 2017: 31 · 2016: 37 · 2015: 28 · 2014: 12
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R44HL097485, P01HL573461)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- biofilm, biofilm-associated infections, antibiofilm strategies, biomedical implants, antibiotic resistance, biofilm inhibition, small molecules, enzymes, biomaterial modification, pathogenic bacteria, infection control
- MeSH terms
- Anti-Bacterial Agents, Biocompatible Materials, Humans, Biofilms
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