Laminin Mimetic Peptide Nanofibers Regenerate Acute Muscle Defect
Abstract
Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for acute muscle injuries, and the stimulation of satellite cell proliferation is promising in this context. In this study, we designed and synthesized a laminin-mimetic bioactive peptide (LM/E-PA) system that is capable of accelerating satellite cell activation by emulating the structure and function of laminin, a major protein of the basal membrane of the skeletal muscle. The LM/E-PA nanofibers enhance myogenic differentiation in vitro and the clinical relevance of the laminin-mimetic bioactive scaffold system was demonstrated further by assessing its effect on the regeneration of acute muscle injury in a rat model. Laminin mimetic peptide nanofibers significantly promoted satellite cell activation in skeletal muscle and accelerated myofibrillar regeneration following acute muscle injury. In addition, the LM/E-PA scaffold treatment significantly reduced the time required for the structural and functional repair of skeletal muscle. This study represents one of the first examples of molecular- and tissue-level regeneration of skeletal muscle facilitated by bioactive peptide nanofibers following acute muscle injury.Significance statement Sports, heavy lifting and other strength-intensive tasks are ubiquitous in modern life and likely to cause acute skeletal muscle injury. Speeding up regeneration of skeletal muscle injuries would not only shorten the duration of recovery for the patient, but also support the general health and functionality of the repaired muscle tissue. In this work, we designed and synthesized a laminin-mimetic nanosystem to enhance muscle regeneration. We tested its activity in a rat tibialis anterior muscle by injecting the bioactive nanosystem. The evaluation of the regeneration and differentiation capacity of skeletal muscle suggested that the laminin-mimetic nanosystem enhances skeletal muscle regeneration and provides a suitable platform that is highly promising for the regeneration of acute muscle injuries. This work demonstrates for the first time that laminin-mimetic self-assembled peptide nanosystems facilitate myogenic differentiation in vivo without the need for additional treatment.
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Laminin mimetic peptide nanofibers promote activation of satellite cell in skeletal muscle and accelerate regeneration myofibrillar following acute muscle injury in SD rats.
“Laminin mimetic peptide nanofibers significantly promote the activation of satellite cell in skeletal muscle and accelerate the regeneration myofibrillar following acute muscle injury in SD rats [47].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [47]
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- Authors
- Eren Cimenci, C., Uzunalli, G., Uysal, O., Yergoz, F., Karaca Umay, E., Guler, M. O., & Tekinay, A. B.
- Affiliations
- University of Chicago (US)
- Bilkent University (TR)
- Corresponding author
- Guler, Mustafa O.
- Tekinay, Ayse B.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 60
- Pages
- 190-200
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2729522819
- Cited by
- 36
- References
- 51
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 2
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Bilkent University Institutional Repository (Bilkent University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- peptide nanofibers, skeletal muscle regeneration, acute muscle injury, satellite cells, myogenesis, bioactive scaffolds, tibialis anterior
- MeSH terms
- Acute Disease, Animals, Laminin, Male, Regeneration, Rats, Sprague-Dawley, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Biomimetic Materials, Rats, Nanofibers
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