Intrinsic and extrinsic mechanisms regulating satellite cell function
Open accessAbstract
Muscle stem cells, termed satellite cells, are crucial for skeletal muscle growth and regeneration. In healthy adult muscle, satellite cells are quiescent but poised for activation. During muscle regeneration, activated satellite cells transiently re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors or symmetric divisions to expand the satellite cell pool. Thus, a complex balance between extrinsic cues and intrinsic regulatory mechanisms is needed to tightly control satellite cell cycle progression and cell fate determination. Defects in satellite cell regulation or in their niche, as observed in degenerative conditions such as aging, can impair muscle regeneration. Here, we review recent discoveries of the intrinsic and extrinsic factors that regulate satellite cell behaviour in regenerating and degenerating muscles.
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Satellite cells are niche stem cells located in skeletal muscle with the capacity to promote adaptation through the contribution of new myonuclei within existing muscle fibres and/or myocytes that can fuse and form new myofibres.
“Satellite cells are niche stem cells located in skeletal muscle with the capacity to promote adaptation through the contribution of new myonuclei within existing muscle fibres and/or myocytes that can fuse and form new myofibres (Dumont et al., 2015).”
From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Dumont et al., 2015
MuSC regenerative function is regulated by interactions with the extrinsic niche, including systemic proteins and local structural and soluble factors that influence cell cycle and transcription and alter muscle biomechanics and contractile forces.
“The regenerative function of MuSCs is regulated by their interaction with components of their extrinsic tissue microenvironment or ‘niche,’ including systemic proteins and localized structural and soluble factors that affect cell cycle and transcriptional regulation18 and alter muscle biomechanical properties and contractile forces19,20.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [18]
Intrinsic modulators control SC-initiated postnatal myogenesis.
“Intrinsic modulators control SC-initiated postnatal myogenesis29.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [29]
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- Authors
- Dumont, N. A., Wang, Y. X., & Rudnicki, M. A.
- Affiliations
- Ottawa Hospital Research Institute (CA)
- University of Ottawa (CA)
- Corresponding author
- Rudnicki, Michael A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-05-01
- Volume
- 142
- Issue
- 9
- Pages
- 1572-1581
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC4419274
- OpenAlex
- W2112326292
- Cited by
- 491
- References
- 106
- Citations by year
- 2026: 36 · 2025: 34 · 2024: 42 · 2023: 40 · 2022: 42 · 2021: 48 · 2020: 58 · 2019: 44 · 2018: 57 · 2017: 39 · 2016: 39 · 2015: 12
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Development (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP81288, MOP12080)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR044031)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- satellite cells, muscle stem cells, muscle regeneration, cell cycle regulation, cell fate determination, asymmetric cell division, symmetric cell division, myogenic progenitor cells, skeletal muscle degeneration, aging
- MeSH terms
- Aging, Animals, Cell Cycle, Cell Differentiation, Cues, Humans, Models, Biological, Regeneration, Signal Transduction, Muscle, Skeletal, Cell Lineage, Muscle Development, Satellite Cells, Skeletal Muscle
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