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Cited by 77Tissue Engineering and Regenerative MedicineCongenital heart defects researchCardiac Fibrosis and Remodeling

Decellularized neonatal cardiac extracellular matrix prevents widespread ventricular remodeling in adult mammals after myocardial infarction

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Wang, Zhouguang, Long, Daniel W., Huang, Yan, Chen, William C.W., Kim, Kang, Wang, Yadong·2019·Acta Biomaterialia
DOI 10.1016/j.actbio.2019.01.062PMC PMC6414086
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Abstract

Heart disease remains a leading killer in western society and irreversibly impacts the lives of millions of patients annually. While adult mammals do not possess the ability to regenerate functional cardiac tissue, neonatal mammals are capable of robust cardiomyocyte proliferation and regeneration within a week of birth. Given this change in regenerative function through development, the extracellular matrix (ECM) from adult tissues may not be conducive to promoting cardiac regeneration, although conventional ECM therapies rely exclusively on adult-derived tissues. Therefore the potential of ECM derived from neonatal mouse hearts (nmECM) to prevent adverse ventricular remodeling in adults was investigated using an in vivo model of acute myocardial infarction (MI). Following a single administration of nmECM, we observed a significant improvement in heart function while adult heart-derived ECM (amECM) did not improve these parameters. Treatment with nmECM limits scar expansion in the left ventricle and promotes revascularization of the injured region. Furthermore, nmECM induced expression of the ErbB2 receptor, simulating a neonatal-like environment and promoting neuregulin-1 associated cardiac function. Inhibition of the ErbB2 receptor effectively prevents these actions, suggesting its role in the context of nmECM as a therapy. This study shows the potential of a neonatal-derived biological material in vivo, diverting from the conventional use of adult-derived ECM therapies in research and the clinic. STATEMENT OF SIGNIFICANCE: The of use extracellular matrix biomaterials to aid tissue repair has been previously reported in many forms of injury. The majority of ECM studies to date utilized ECM derived from adult tissues that are not able to fully regenerate functional tissue. In contrast, this study tests the ability of ECM derived from a regenerative organ, the neonatal heart, to stimulate functional cardiac repair after MI. This study is the first to test its potential in vivo. Our results indicate that extracellular factors present in the neonatal environment can be used to alter the healing response in adults, and we have identified the role of ErbB2 in neonatal ECM-based cardiac repair.

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  • The content of laminin, elastin, and growth factors decreases with age.

    “Moreover, the content of laminin, elastin, and growth factors decreases with age [30,37,84,85].”

    From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [84]

    The Results section ('Neonatal and adult-derived tissues are distinct biomaterials'; page unavailable) reports less elastin in adult than neonatal mouse cardiac ECM. The composition analysis did not measure laminin or growth-factor content, so this paper does not support those parts of the claim. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Sorted by citations

Authors
Wang, Z., Long, D. W., Huang, Y., Chen, W. C. W., Kim, K., & Wang, Y.
Affiliations
University of Pittsburgh (US)
Corresponding author
Wang, Yadong
ORCID
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2019-03
Volume
87
Pages
140-151
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2019.01.062
PMC
PMC6414086
OpenAlex
W2913768376
Cited by
77
References
1
Citations by year
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FWCI
9.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Acta Biomaterialia (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (1S10RR027383-01, 5T32HL007208, 5T32EB003392-13)
  • University of Pittsburgh
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
decellularized extracellular matrix, neonatal heart, myocardial infarction, ventricular remodeling, cardiac regeneration, ErbB2 receptor, neuregulin-1, cardiac revascularization, cardiac repair
MeSH terms
Animals, Extracellular Matrix, Female, Humans, Male, Mice, Inbred BALB C, Myocardial Infarction, Myocardium, Regeneration, Ventricular Remodeling, Mice, Human Umbilical Vein Endothelial Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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