The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications
Abstract
In recent years, Zn-based materials provide a new option as biodegradable metals for orthopedic applications. To improve the low strength and brittle nature of pure Zn, small amounts of alloying element Mn (0.1, 0.4 and 0.8 wt. %) were added into Zn to fabricate binary Zn-Mn alloys. An extremely high elongation (83.96 ± 2.36%) was achieved in the resulting Zn-0.8wt.%Mn alloy. Moreover, Zn-Mn alloys displayed significantly improved cytocompatibility as compared to pure Zn, according to cell proliferation and morphology analyses. More importantly, a significantly improved osteogenic activity was verified after adding Mn regarding ALP activity and osteogenic expression. Furthermore, Zn-0.8wt.%Mn alloy scaffolds were implanted into the rat femoral condyle for repairing bone defects with pure Ti as control. Enhanced osteogenic activities were confirmed for Zn-0.8Mn alloy in contrast to pure Ti based on Micro-CT and histological results, and favorable in vivo biosafety of Zn-0.8Mn alloy was verified by H&E staining and blood tests. The exceptional mechanical performance and favorable osteogenic capability render Zn-Mn alloy a promising candidate material in the treatment of bone defects or fracture repair. Statements of significance The element Mn, on the one hand, as an essential trace element in the human body, promotes cell proliferation, adhesion, spreading, and regulates bone metabolism; on the other hand, it could significantly improve the ductility of Zn alloys. Here, we systematically reported the biocompatibility and biofunctionality of binary biodegradable Zn-Mn alloys in the bone environment. The Zn-Mn alloys promoted MC3T3-E1 cell proliferation, adhesion, spreading, and osteogenic differentiation in vitro. Furthermore, a rat femoral condyle defect model was established; porous Zn-Mn alloy scaffolds were manufactured to repair the bone defects. Significant bone regenerations, considerable bone ingrowth, and desirable biosafety were confirmed in vivo. Therefore, biodegradable Zn-Mn with promising osteogenic properties may become new options for orthopedic implant materials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zheng, Y. F., Gu, X. N., & Witte, F. (2014) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2014.01.001 · Cited by 2,436
Self-citationFunction and Mechanism of Zinc Metalloenzymes
McCall, K. A., Huang, C.-C., & Fierke, C. A. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1437s · Cited by 1,136
Alloying design of biodegradable zinc as promising bone implants for load-bearing applications
Yang, H., Jia, B., Zhang, Z., Qu, X., Li, G., Lin, W., Zhu, D., Dai, K., & Zheng, Y. (2020) · Nature Communications · doi:10.1038/s41467-019-14153-7 · Cited by 756
Self-citationZinc-based alloys for degradable vascular stent applications
Mostaed, E., Sikora-Jasinska, M., Drelich, J. W., & Vedani, M. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.005 · Cited by 565
Biodegradable Metals for Cardiovascular Stents: from Clinical Concerns to Recent Zn‐Alloys
Bowen, P. K., Shearier, E. R., Zhao, S., Guillory, R. J., Zhao, F., Goldman, J., & Drelich, J. W. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201501019 · Cited by 544
Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr
Li, H. F., Xie, X. H., Zheng, Y. F., Cong, Y., Zhou, F. Y., Qiu, K. J., Wang, X., Chen, S. H., Huang, L., Tian, L., et al. (2015) · Scientific Reports · doi:10.1038/srep10719 · Cited by 515
Self-citationRole of nutritional zinc in the prevention of osteoporosis
Yamaguchi, M. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0358-0 · Cited by 396
Corrosion resistance and surface biocompatibility of a microarc oxidation coating on a Mg–Ca alloy
Gu, X. N., Li, N., Zhou, W. R., Zheng, Y. F., Zhao, X., Cai, Q. Z., & Ruan, L. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.11.034 · Cited by 383
Self-citationShen, X., Zhang, Y., Ma, P., Sutrisno, L., Luo, Z., Hu, Y., Yu, Y., Tao, B., Li, C., & Cai, K. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.05.008 · Cited by 291
Li, Y., Liu, L., Wan, P., Zhai, Z., Mao, Z., Ouyang, Z., Yu, D., Sun, Q., Tan, L., Ren, L., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.031 · Cited by 286
Self-citation
Cited by
Mei, D., Lamaka, S. V., Lu, X., & Zheludkevich, M. L. (2020) · Corrosion Science · doi:10.1016/j.corsci.2020.108722 · Cited by 284
Biodegradable magnesium‐based biomaterials: An overview of challenges and opportunities
Amukarimi, S., & Mozafari, M. (2021) · MedComm · doi:10.1002/mco2.59 · Cited by 258
Wang, S., Gu, R., Wang, F., Zhao, X., Yang, F., Xu, Y., Yan, F., Zhu, Y., Xia, D., & Liu, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100202 · Cited by 115
Surface Functionalized Zinc Composite Coatings: A Review
Awasthi, S., Palomero, B. P., Srivastava, A., Selvaraj, S., Kumar, D., & Pandey, S. K. (2025) · Advanced Engineering Materials · doi:10.1002/adem.202401597 · Cited by 6
Metadata
- Authors
- Jia, B., Yang, H., Han, Y., Zhang, Z., Qu, X., Zhuang, Y., Wu, Q., Zheng, Y., & Dai, K.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 108
- Pages
- 358-372
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W3011285626
- Cited by
- 253
- References
- 41
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications. https://app.cochat.ai/papers/10.1016/j.actbio.2020.03.009
- The paper
- Jia, B., Yang, H., Han, Y., Zhang, Z., Qu, X., Zhuang, Y., Wu, Q., Zheng, Y., & Dai, K. (2020). In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.03.009
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
