The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fabrication of magnesium/zinc-metal organic framework on titanium implants to inhibit bacterial infection and promote bone regeneration
Open accessAbstract
The residual bacteria in the second revision surgery caused by infection would further lead to the failure of the implantation. Pathogenic bacteria adhesion to an implant surface not only interfere the functions of bone-formation related cells, but also activate the host immune system, thus resulting in inflammation and osteogenesis inhibition. Thus, to fabricate multifunctional (antibacterial, anti-inflammation and pro-osteogenesis) titanium implants is essential to address this issue. In this work, hybrid magnesium/zinc-metal organic framework (Mg/Zn-MOF74) coating was constructed on alkali-heat treated titanium (AT) surface. The hybrid Mg/Zn-MOF74 coating displayed good stability and its stability was related to the content of Zn2+. The MOF74-modified samples were sensitive to bacterial acid microenvironment and displayed strong antibacterial ability against both Escherichia coli and Staphylococcus aureus due to the degradation of MOF74 coating, leading to alkaline microenvironment (about pH 8.0) and degradation products (2,5-dihydroxyterephthalic acid and Zn2+). The coating also showed good early anti-inflammatory property to native Ti substrates. In vivo results further verified that AT-Mg/Zn3 implants had high antibacterial and anti-inflammatory properties at early stage of implantation, and greatly improved new bone formation around implants both at non-infected and infected femur sites.
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Cites
Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy
Zhang, Y., Wang, F., Liu, C., Wang, Z., Kang, L., Huang, Y., Dong, K., Ren, J., & Qu, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b07746 · Cited by 854
Self-citationBao, X., Zhao, J., Sun, J., Hu, M., & Yang, X. (2018) · ACS Nano · doi:10.1021/acsnano.8b04022 · Cited by 722
Cited by
Yin, M., Wu, J., Deng, M., Wang, P., Ji, G., Wang, M., Zhou, C., Blum, N. T., Zhang, W., Shi, H., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c06036 · Cited by 380
Scaffolds for bone-tissue engineering
Lee, S. S., Du, X., Kim, I., & Ferguson, S. J. (2022) · Matter · doi:10.1016/j.matt.2022.06.003 · Cited by 375
In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications
Jia, B., Yang, H., Han, Y., Zhang, Z., Qu, X., Zhuang, Y., Wu, Q., Zheng, Y., & Dai, K. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.03.009 · Cited by 253
Tao, B., Zhao, W., Lin, C., Yuan, Z., He, Y., Lu, L., Chen, M., Ding, Y., Yang, Y., Xia, Z., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124621 · Cited by 206
Self-citationCurrent status and prospects of metal-organic frameworks for bone therapy and bone repair
Li, M., Yin, S., Lin, M., Chen, X., Pan, Y., Peng, Y., Sun, J., Kumar, A., & Liu, J. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00742h · Cited by 156
Metadata
- Authors
- Shen, X., Zhang, Y., Ma, P., Sutrisno, L., Luo, Z., Hu, Y., Yu, Y., Tao, B., Li, C., & Cai, K.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 212
- Pages
- 1-16
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2944085181
- Cited by
- 291
- References
- 2
- FWCI
- 32.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shen, X., Zhang, Y., Ma, P., Sutrisno, L., Luo, Z., Hu, Y., Yu, Y., Tao, B., Li, C., & Cai, K. (2019). Fabrication of magnesium/zinc-metal organic framework on titanium implants to inhibit bacterial infection and promote bone regeneration. Biomaterials. https://doi.org/10.1016/j.biomaterials.2019.05.008
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