Differential cigarette-related startle cue reactivity among light, moderate, and heavy smokers
Open accessAbstract
In this study, we examined the relationship between the level of daily cigarette consumption and the startle response to affective and cigarette-related cues among treatment-seeking smokers. Before receiving any behavioral or pharmacological treatment, 136 smokers attended a baseline laboratory session, during which we recorded their reflexive eyeblink responses to acoustic startle probes while they were viewing pleasant, unpleasant, neutral, and cigarette-related pictures. We found that 1) cigarette-related and pleasant pictures similarly reduced the startle magnitude compared to neutral pictures; 2) the magnitude of startle modulation rendered by pleasant or unpleasant pictures did not differ among light, moderate, and heavy smokers; and 3) startle attenuation by cigarette-related pictures was greater in heavy smokers than in light smokers. These results suggest that similar to pleasant stimuli, cigarette-related cues are motivationally salient for smokers, and that this salience increases with nicotine dependence.
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Smoking-related cues have repeatedly been shown to induce craving on a physiological, neural and subjective level, and the extent of craving has been associated with the severity of nicotine use and dependence.
“Smoking-related cues have repeatedly been shown to induce craving on a physiological, neural and subjective level (Betts et al., 2021; Cui et al., 2012; Lin et al., 2020), of which the extent of craving has been associated with the severity of nicotine use and dependence (Lin et al., 2020; Vollst ¨ adt-Klein et al., 2011).”
From Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults. (2023) · cites this paper as Cui et al., 2012
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“Smoking-related cues have repeatedly been shown to induce craving on a physiological, neural and subjective level (Betts et al., 2021; Cui et al., 2012; Lin et al., 2020), of which the extent of craving has been associated with the severity of nicotine use and dependence (Lin et al.”
Background
- Authors
- Cui, Y., Robinson, J. D., Versace, F., Lam, C. Y., Minnix, J. A., Karam-Hage, M., Dani, J. A., Kosten, T. R., Wetter, D. W., Brown, V. L., & Cinciripini, P. M.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Cinciripini, Paul M.
- ORCID
- Venue
- Addictive Behaviors
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 37
- Issue
- 8
- Pages
- 885-889
- ISSN
- 0306-4603 (ISSN-L)
- PMC
- PMC3358408
- OpenAlex
- W2028022741
- Cited by
- 23
- References
- 52
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Addictive Behaviors (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- National Institute on Drug Abuse (R01DA017073)
- National Cancer Institute (CA 016672, P30CA016672)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- startle response, eyeblinks, cue reactivity, nicotine dependence, smoking intensity, emotional cues, motivational salience, smokers
- MeSH terms
- Adolescent, Adult, Aged, Blinking, Cues, Female, Humans, Male, Middle Aged, Smoking, Reflex, Startle, Texas, Smoking Cessation, Young Adult
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