Cited by 382Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudySubstance Abuse Treatment and Outcomes

Nicotine addiction and comorbidity with alcohol abuse and mental illness

Dani, John A, Harris, R Adron·2005·Nature Neuroscience

Abstract

The World Health Organization estimates that one-third of the global adult population smokes. Because tobacco use is on the rise in developing countries, death resulting from tobacco use continues to rise. Nicotine, the main addictive component of tobacco, initiates synaptic and cellular changes that underlie the motivational and behavioral alterations that culminate in addiction. Nicotine addiction progresses rapidly in adolescents and is most highly expressed in vulnerable people who have psychiatric illness or other substance abuse problems.

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Crossref · 10.1038/nn1580

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96 of 96 references verified0 citation errors · 0 not checkable

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  • Smoking and drinking are two of the earliest drug use behaviors in human teens, and many reports indicate a positive interaction between smoking and drinking in this age group.

    “Smoking and drinking are two of the earliest drug use behaviors in human teens, and many reports indicate a positive interaction of smoking and drinking in this age group (Dani & Harris, 2005; Kristjansson et al., 2015).”

    From Unique, long-term effects of nicotine on adolescent brain. (2020) · cites this paper as Dani & Harris, 2005

  • Anxiety has been shown to impact relapse rate.

    “Although craving and cognitive impairments are reliable markers of nicotine withdrawal (Kenney and Gould, 2008; Levin et al, 2006; McClernon et al, 2004; Rezvani and Levin, 2001), anxiety has been shown to impact relapse rate as well (Dani and Harris, 2005; DiMatteo et al, 2000).”

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Authors
Dani, J. A., & Harris, R. A.
Affiliations
  • Baylor College of Medicine (US)
  • The University of Texas at Austin (US)
Venue
Nature Neuroscience
Published
2005-10-26
Volume
8
Issue
11
Pages
1465-1470
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2147927117
Cited by
382
References
95
Citations by year
2026: 6 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 9 · 2020: 18 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 21 · 2015: 27 · 2014: 23 · 2013: 31 · 2012: 17
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS021229)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
nicotine dependence, tobacco use, alcohol abuse, psychiatric comorbidity, substance use disorders, adolescent smoking, synaptic changes, addiction vulnerability
MeSH terms
Alcoholism, Mental Disorders, Humans, Limbic System, Models, Biological, Reward, Tobacco Use Disorder, Comorbidity

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