Nicotine addiction and comorbidity with alcohol abuse and mental illness
Abstract
The World Health Organization estimates that one-third of the global adult population smokes. Because tobacco use is on the rise in developing countries, death resulting from tobacco use continues to rise. Nicotine, the main addictive component of tobacco, initiates synaptic and cellular changes that underlie the motivational and behavioral alterations that culminate in addiction. Nicotine addiction progresses rapidly in adolescents and is most highly expressed in vulnerable people who have psychiatric illness or other substance abuse problems.
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Smoking and drinking are two of the earliest drug use behaviors in human teens, and many reports indicate a positive interaction between smoking and drinking in this age group.
“Smoking and drinking are two of the earliest drug use behaviors in human teens, and many reports indicate a positive interaction of smoking and drinking in this age group (Dani & Harris, 2005; Kristjansson et al., 2015).”
From Unique, long-term effects of nicotine on adolescent brain. (2020) · cites this paper as Dani & Harris, 2005
Anxiety has been shown to impact relapse rate.
“Although craving and cognitive impairments are reliable markers of nicotine withdrawal (Kenney and Gould, 2008; Levin et al, 2006; McClernon et al, 2004; Rezvani and Levin, 2001), anxiety has been shown to impact relapse rate as well (Dani and Harris, 2005; DiMatteo et al, 2000).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Dani and Harris, 2005
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- Authors
- Dani, J. A., & Harris, R. A.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas at Austin (US)
- Venue
- Nature Neuroscience
- Published
- 2005-10-26
- Volume
- 8
- Issue
- 11
- Pages
- 1465-1470
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2147927117
- Cited by
- 382
- References
- 95
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 9 · 2020: 18 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 21 · 2015: 27 · 2014: 23 · 2013: 31 · 2012: 17
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS021229)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- nicotine dependence, tobacco use, alcohol abuse, psychiatric comorbidity, substance use disorders, adolescent smoking, synaptic changes, addiction vulnerability
- MeSH terms
- Alcoholism, Mental Disorders, Humans, Limbic System, Models, Biological, Reward, Tobacco Use Disorder, Comorbidity
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