Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder
Open accessAbstract
Background Psychological items discriminating children of fathers diagnosed with an illicit drug-related substance use disorder and normal controls are indicators of a unidimensional construct termed transmissible liability index (TLI) (Vanyukov et al., 2009). TLI is a highly heritable (Vanyukov et al., 2009; Hicks, Iacono, McGue, 2012) and valid (Vanyukov et al., 2009; Hicks et al., 2009; Kirisci et al., 2013a) measure of childhood liability to substance use disorders (SUDs).Aims This longitudinal study determined whether TLI has incremental validity for predicting SUD beyond commonly measured psychological indicators of risk.Methods TLI and measures of executive cognitive capacity, emotion dysregulation and externalizing disturbance were administered to boys at ages 10-12 and 16. SUD outcome determined at age 22 was assessed as (1) any SUD, (2) the number of drug-specific SUDs, and (3) SUD severity.Results TLI predicted SUD beyond the contribution of measures of emotion dysregulation, executive cognitive capacity and externalizing disturbance. The association of emotion dysregulation and externalizing behavior at ages 10-12 and 16 with SUD at age 22 was also reduced to non-significance after controlling for transmissible risk measured by TLI.Conclusions TLI's incremental validity beyond these latter indicators of risk points to its utility for identifying vulnerable youths requiring intervention.
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Emotion dysregulation at ages 12 and 16 years predicts the risk of developing a substance use disorder in early adulthood.
“Emotion dysregulation at the ages of 12 and 16 years has been found to predict the risk of developing a SUD in early adulthood [94].”
From Emotion regulation in substance use disorders: a systematic review and meta-analysis (2023) · cites this paper as [94]
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“Contents lists available at ScienceDirect Addictive Behaviors Indeed, the order of drug use initiation specified in the “gateway hypothesis” (Kandel & Yamaguchi, 2002) is less informative than TLI for modeling SUD development between childhood and adulthood (Tarter et al., 2012a).”
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- Authors
- Kirisci, L., Tarter, R., Ridenour, T., Reynolds, M., Horner, M., & Vanyukov, M.
- Affiliations
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- Corresponding author
- Kirisci, Levent
- Venue
- Addictive Behaviors
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 42
- Pages
- 57-62
- ISSN
- 0306-4603 (ISSN-L)
- PMC
- PMC4272861
- OpenAlex
- W2024501320
- Cited by
- 19
- References
- 33
- Citations by year
- 2025: 1 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 1 · 2017: 1 · 2015: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addictive Behaviors (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (P50-DA 05605, K02DA017822, P50DA005605, K05DA031248)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Demography › Youth, Drugs, and Violence
- Keywords
- substance use disorders, emotional dysregulation, externalizing problems, executive function, heritability, incremental validity, adolescent boys, risk prediction
- MeSH terms
- Adolescent, Affective Symptoms, Child, Humans, Longitudinal Studies, Male, Risk Factors, Child of Impaired Parents, Intergenerational Relations, Conduct Disorder, Attention Deficit and Disruptive Behavior Disorders, Substance-Related Disorders, Young Adult
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