Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability
Open accessAbstract
The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI's phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.
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In a twin study of ages 9-18, the Transmissible Liability Index showed a high degree of heritability (0.79).
“In a twin study (i.e., ages 9–18-years-old: Vanyukov et al., 2009), TLI showed a high degree of heritability (i.e., 0.79).”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Vanyukov et al., 2009
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“…disorder Children Risk Family history Background: Psychological items discriminating children of fathers diagnosed with an illicit drug-related substance use disorder and normal controls are indicators of a unidimensional construct termed transmissible liability index (TLI) (Vanyukov et al., 2009).”
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The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project
Vanyukov, M. M., MAES, H. H. M., Iacono, W. G., Kirisci, L., Samek, D. R., Silberg, J. L., Zimmerman, E. B., & Prom‐Wormley, E. C. (2023) · Twin Research and Human Genetics · doi:10.1017/thg.2023.8 · Cited by 6 · see citing works
Tarter, R. E., Kirisci, L., & Reynolds, M. (2014) · Substance Abuse · doi:10.1080/08897077.2014.956918 · Cited by 6 · see citing works
Informing Prevention and Intervention Policy Using Genetic Studies of Resistance
Maher, B. S., Latendresse, S. J., & Vanyukov, M. M. (2016) · Prevention Science · doi:10.1007/s11121-016-0730-8 · Cited by 6 · see citing works
Brown, A. L., España, R., Benca‐Bachman, C. E., Welsh, J. W., & Palmer, R. H. C. (2020) · Substance Abuse Research and Treatment · doi:10.1177/1178221820970925 · Cited by 5 · see citing works
Introduction to Metrics in Person Centered Medicine Research
Kirisci, L., Vanyukov, M. M., & Mezzich, J. E. (2017) · The International Journal of Person Centered Medicine · doi:10.5750/ijpcm.v6i4.611 · Cited by 5 · see citing works
Abou‐Saleh, M. T., Tarter, R. E., & Salloum, I. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-39724-5_24 · Cited by 4 · see citing works
Brick, L., Benca-Bachman, C., Bertin, L., Martin, K. P., Risner, V. A., & Palmer, R. (2021) · Addiction · doi:10.1111/add.15476 · Cited by 4 · see citing works
Sharma, P., Riehm, K. E., Young, A. S., Reynolds, M., Tarter, R. E., Horner, M. S., & Hammond, C. J. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1964086 · Cited by 4 · see citing works
Substance Use: Disorders and Continuous Traits
Kirisci, L., & Vanyukov, M. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-95350-8_1 · Cited by 4 · see citing works
Tarter, R. E., Kirisci, L., Reynolds, M., Horner, M. S., Zhai, Z. W., Gathuru, I. M., & Vanyukov, M. M. (2015) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000163 · Cited by 4 · see citing works
Garofalo, C., Weller, J. A., Kirisci, L., Reynolds, M., & Mazzeschi, C. (2024) · Development and Psychopathology · doi:10.1017/s0954579424001639 · Cited by 3 · see citing works
Psychological Antecedents and Correlates of Substance Use and Addiction
Tarter, R. E., & Reynolds, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-95350-8_3 · Cited by 3 · see citing works
Substance Use Disorders in Adolescence
Szobot, C. M., & Bukstein, O. G. (2008) · KARGER eBooks · doi:10.1159/000118523 · Cited by 2 · see citing works
Prevention of Opioid Addiction
Tarter, R. E., Cochran, G., & Reynolds, M. (2018) · Commonwealth · doi:10.15367/com.v20i2-3.187 · Cited by 2 · see citing works
Cornelius, J. R., Kirisci, L., Reynolds, M., Vanyukov, M. M., & Tarter, R. E. (2015) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2015.1011744 · Cited by 2 · see citing works
Cornelius, J. R., & Kirisci, L. (2013) · PubMed · Cited by 1 · see citing works
Understanding the role of race, ethnicity, and culture in the development of polysubstance use
Banks, D. E., Campbell, K. D., & Ghonasgi, R. (2023) · The Psychology of learning and motivation/The psychology of learning and motivation · doi:10.1016/bs.plm.2023.06.003 · Cited by 1 · see citing works
Cheslack‐Postava, K., Cycowicz, Y. M., Rodriguez‐Moreno, D. V., Amsel, L., Musa, G. J., Ryan, M., Bresnahan, M. A., Tang, H., Geronazzo‐Alman, L., Bisaga, A. M., et al. (2024) · Children · doi:10.3390/children11060671 · Cited by 1 · see citing works
Wood, E. E., Liang, Y., Moon, T., Hill‐Kapturczak, N., Wasserman, A. M., Roache, J. D., Mathias, C. W., Blumenthal, H., & Dougherty, D. M. (2024) · Substance Use & Misuse · doi:10.1080/10826084.2024.2434007 · Cited by 1 · see citing works
Hulvershorn, L. A., Hummer, T. A., Wu, Y., Tarter, R. E., Rea, P., Anand, A., Chambers, R. A., & Finn, P. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9679-x · Cited by 1 · see citing works
Phenotypic and Genetic Analysis of Indices of Liability to Addiction
Infante, E. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
An investigation of the dark side of information technology use: three essays on IT addiction
Vaghefi, A., & Vaghefi, S. E. A. (2016)
Mahrs-Gould, R., Jallo, N., Svikis, D. S., Ameringer, S., Robins, J. L. W., & Elswick, R. K. (2024) · Journal of Ethnicity in Substance Abuse · doi:10.1080/15332640.2024.2331108
Tarhan, N., Demirsoy, Ç., & Tutgun-Ünal, A. (2025) · Psychiatry International · doi:10.3390/psychiatryint6010019
Benca‐Bachman, C. E., Najera, D. D., Delawalla, C. N., Jaume-Feliciosi, N., McGeary, J. E., & Palmer, R. H. C. (2025) · Research Square · doi:10.21203/rs.3.rs-6157562/v1
- Authors
- Vanyukov, M. M., Kirisci, L., Moss, L., Tarter, R. E., Reynolds, M. D., Maher, B. S., Kirillova, G. P., Ridenour, T., & Clark, D. B.
- Affiliations
- University of Pittsburgh (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Vanyukov, Michael M.
- ORCID
- Venue
- Behavior Genetics
- Published
- 2009-04-18
- Volume
- 39
- Issue
- 3
- Pages
- 233-244
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- PMC
- PMC3099440
- OpenAlex
- W1990798140
- Cited by
- 88
- References
- 35
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 11
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01da011922-05)
- National Institute on Alcohol Abuse and Alcoholism (K01AA000296, K02AA00296)
- National Institute on Drug Abuse (R01-DA011922, K02DA017822, P50DA005605, R01DA019157, K02DA018701)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Keywords
- substance use disorders, latent trait measurement, item response theory, heritability, twin studies, ethnic differences, illicit drug use, risk prediction
- MeSH terms
- Adolescent, Age Factors, Marijuana Abuse, Child, Diseases in Twins, Genotype, Humans, Longitudinal Studies, Male, Opioid-Related Disorders, Phenotype, Pilot Projects, Risk, Social Environment, Illicit Drugs, Twins, Dizygotic, Twins, Monozygotic, Logistic Models, Proportional Hazards Models, Child of Impaired Parents, Substance-Related Disorders, Cocaine-Related Disorders, Genetic Predisposition to Disease, Young Adult
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