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Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications
Open accessAbstract
The present paper intends to overview a wide range of natural-origin polymers with special focus on proteins and polysaccharides (the systems more inspired on the extracellular matrix) that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues. The combination of both applications into a single material has proven to be very challenging though. The paper presents also some examples of commercially available natural-origin polymers with applications in research or in clinical use in several applications. As it is recognized, this class of polymers is being widely used due to their similarities with the extracellular matrix, high chemical versatility, typically good biological performance and inherent cellular interaction and, also very significant, the cell or enzyme-controlled degradability. These biocharacteristics classify the natural-origin polymers as one of the most attractive options to be used in the tissue engineering field and drug delivery applications.
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Cites
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
Polymer blends and composites from renewable resources
Yu, L., Dean, K., & Li, L. (2006) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2006.03.002 · Cited by 2,107
Inoue, S., Tanaka, K., Arisaka, F., Kimura, S., Ohtomo, K., & Mizuno, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006897200 · Cited by 784
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575
Applications of Polymer Nanofibers in Biomedicine and Biotechnology
Venugopal, J., & Ramakrishna, S. (2005) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:125:3:147 · Cited by 370
Cited by
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703
Vroman, I., & Tighzert, L. (2009) · Materials · doi:10.3390/ma2020307 · Cited by 1,355
Advancing biomaterials of human origin for tissue engineering
Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158
Natural and synthetic polymers for wounds and burns dressing
Mogoşanu, G. D., & Grumezescu, A. M. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.12.015 · Cited by 1,052
Biodegradable and biocompatible polymers for tissue engineering application: A review
Asghari, F., Samiei, M., Adibkia, K., Akbarzadeh, A., & Davaran, S. (2017) · Artificial Cells, Nanomedicine, and Biotechnology · doi:10.3109/21691401.2016.1146731 · Cited by 482
Metadata
- Authors
- Malafaya, P. B., Silva, G. A., & Reis, R. L.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 59
- Issue
- 4-5
- Pages
- 207-233
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2154659743
- Cited by
- 1,401
- References
- 5
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Malafaya, P. B., Silva, G. A., & Reis, R. L. (2007). Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2007.03.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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