Cited by 440Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Targeted delivery of nanoparticles for the treatment of lung diseases

Azarmi, Shirzad, Roa, Wilson H., Löbenberg, Raimar·2008·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2007.11.006

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Abstract

Targeted delivery of drug molecules to organs or special sites is one of the most challenging research areas in pharmaceutical sciences. By developing colloidal delivery systems such as liposomes, micelles and nanoparticles a new frontier was opened for improving drug delivery. Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other delivery systems. Targeted nanoparticle delivery to the lungs is an emerging area of interest. This article reviews research performed over the last decades on the application of nanoparticles administered via different routes of administration for treatment or diagnostic purposes. Nanotoxicological aspects of pulmonary delivery are also discussed.

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Authors: Azarmi, S., Roa, W. H., & Löbenberg, R.
Affiliations: University of Alberta (CA)
Corresponding author: Löbenberg, Raimar
ORCID: Roa, Wilson H.
Löbenberg, Raimar
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2008-05
Volume: 60
Issue: 8
Pages: 863-875
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2007.11.006
OpenAlex: W1972609612
Cited by: 440
References: 99
Citations by year: 2026: 11 · 2025: 12 · 2024: 22 · 2023: 25 · 2022: 27 · 2021: 25 · 2020: 24 · 2019: 23 · 2018: 18 · 2017: 21 · 2016: 27 · 2015: 28 · 2014: 35 · 2013: 25 · 2012: 33
FWCI: 4.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: targeted drug delivery, nanoparticles, lung disease, pulmonary drug delivery, liposomes, micelles, colloidal drug delivery systems, route of administration, nanotoxicology
MeSH terms: Animals, Antibodies, Monoclonal, Humans, Lung, Lung Diseases, Magnetics, Drug Delivery Systems, Gene Transfer Techniques, Nanoparticles

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Targeted delivery of nanoparticles for the treatment of lung diseases

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