The DOI matches its Crossref record; 95 of the 99 references it cites were found in a registry or an index.
Targeted delivery of nanoparticles for the treatment of lung diseases
Abstract
Targeted delivery of drug molecules to organs or special sites is one of the most challenging research areas in pharmaceutical sciences. By developing colloidal delivery systems such as liposomes, micelles and nanoparticles a new frontier was opened for improving drug delivery. Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other delivery systems. Targeted nanoparticle delivery to the lungs is an emerging area of interest. This article reviews research performed over the last decades on the application of nanoparticles administered via different routes of administration for treatment or diagnostic purposes. Nanotoxicological aspects of pulmonary delivery are also discussed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast to i.v. administration, i.t. administration via suspension nebulization or dry powder inhalation can directly deliver mRNA to the airways of the lungs.[184]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [184]
In the citing paper
“Moreover, using i.t. administration, mRNA can be delivered to a variety of cell types, such as alveolar cells, pulmonary endothelium, and immune cells.[126, 184]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [184]
Citations
Cites
Continuous cultures of fused cells secreting antibody of predefined specificity
Köhler, G., & Milstein, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,200
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Hillery, A. M., Lloyd, A. W., & Swarbrick, J. (2016) · CRC Press eBooks · doi:10.1201/b12801 · Cited by 2,031
Xia, T., Kovochich, M., Brant, J. A., Hotze, M., Sempf, J. M., Oberley, T. D., Sioutas, C., Yeh, J. I., Wiesner, M. R., & Nel, A. E. (2006) · Nano Letters · doi:10.1021/nl061025k · Cited by 1,931
Comparative Pulmonary Toxicity Assessment of Single-wall Carbon Nanotubes in Rats
Warheit, D. B. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg228 · Cited by 1,531
Large Porous Particles for Pulmonary Drug Delivery
Edwards, D. A., Hanes, J. S., Caponetti, G., Hrkach, J. S., Ben-Jebria, A., Eskew, M. L., Mintzes, J. D., Deaver, D. R., Lotan, N., & Langer, R. (1997) · Science · doi:10.1126/science.276.5320.1868 · Cited by 1,184
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
Jani, P., Halbert, G. W., Langridge, J., & Florence, A. T. (1990) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1990.tb07033.x · Cited by 920
Sayes, C. M., Reed, K. L., & Warheit, D. B. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm018 · Cited by 769
The Potential Advantages of Nanoparticle Drug Delivery Systems in Chemotherapy of Tuberculosis
Gelperina, S. E., Kisich, K. O., Iseman, M. D., & Heifets, L. B. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-613pp · Cited by 744
Green, M. R., Manikhas, G. M., Орлов, С. В., Afanasyev, B. V., Makhson, A. M., Bhar, P., & Hawkins, M. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl104 · Cited by 671
Flagged first, then by citations
4 of the 99 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Clark, 2002, Formulation of proteins and peptides for inhalation, Drug Deliv. Syst. Sci., 2, 73
- Page, 1996, Entrapment of colistin into polyhexylcyanoacrylate nanoparticles: preparation, drug release and tissue distribution in mice, S.T.P. Pharm. Sci., 6, 298
- Leucuta, 2003, Preparation and pharmaceutical/pharmacokinetic characterization of liposomes and nanoparticles loaded with epirubicin, S.T.P. Pharm. Sci., 13, 291
- Shvedova, 2003, Exposure to carbon nanotube material: evidence of exposure-induced oxidant stress in human keratinocyte and bronchial epithelial cells, Free Radic. Res., 37, 97
Cited by
Sorted by citations
mRNA-based therapeutics--developing a new class of drugs
Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474
Treating metastatic cancer with nanotechnology
Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3180 · Cited by 1,175
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,140
Xu, M., Qi, Y., Liu, G. H., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 654
Weber, S., Zimmer, A., & Pardeike, J. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.08.013 · Cited by 579
Metadata
- Authors
- Azarmi, S., Roa, W. H., & Löbenberg, R.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Löbenberg, Raimar
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 60
- Issue
- 8
- Pages
- 863-875
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1972609612
- Cited by
- 440
- References
- 99
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 22 · 2023: 25 · 2022: 27 · 2021: 25 · 2020: 24 · 2019: 23 · 2018: 18 · 2017: 21 · 2016: 27 · 2015: 28 · 2014: 35 · 2013: 25 · 2012: 33
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted drug delivery, nanoparticles, lung disease, pulmonary drug delivery, liposomes, micelles, colloidal drug delivery systems, route of administration, nanotoxicology
- MeSH terms
- Animals, Antibodies, Monoclonal, Humans, Lung, Lung Diseases, Magnetics, Drug Delivery Systems, Gene Transfer Techniques, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review