Nanoparticle formulations in pulmonary drug delivery

Bailey, Mark M.; Berkland, Cory J.

doi:10.1002/med.20140

Cited by 302Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Nanoparticle formulations in pulmonary drug delivery

Bailey, Mark M., Berkland, Cory J.·2009·Medicinal Research Reviews

DOI 10.1002/med.20140

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Abstract

The advent of nanotechnology has reignited interest in the lungs as a major route of drug delivery for both systemic and local treatments. The large surface area of the lungs and the minimal barriers impeding access to the lung periphery make this organ a suitable portal for a variety of therapeutic interventions. Nanoparticles provide new formulation options for both dispersed liquid droplet dosage forms such as metered dose inhalers and nebulizers, and dry powder formulations. Nanoparticle formulations have many advantages over traditional dosage forms, such as enhanced dissolution properties and the potential for intracellular drug delivery. Specifically, pure drug nanoparticles, polymeric nanoparticles, polyelectrolyte complexes, and drug‐loaded liposomes offer some encouraging results for delivering drugs to and through the lungs. Methods are also being investigated to produce nanoparticles with properties suitable for improving access to the peripheral lung. Traditional techniques such as spray drying and grinding, and more recent advances in supercritical fluid extraction, precipitation, and solvent extraction have been employed to produce nanoparticle formulations for pulmonary delivery. Here, the benefits of nanoparticle formulations and current progress are compared in light of the practical encumbrances of producing formulations, and possible toxicological effects of these materials. © 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 1, 196–212, 2009

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Polymeric materials have shown potential as drug delivery vehicles due to high biocompatibility and biodegradability.
“Polymeric materials have shown tremendous potential as drug delivery vehicles due to their high biocompatibility and biodegradability.163”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [163]

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Advances in crystal growing technology
(1966) · Microelectronics Reliability · doi:10.1016/0026-2714(66)90041-2

Authors: Bailey, M. M., & Berkland, C. J.
Affiliations: University of Kansas (US)
Corresponding author: Berkland, Cory J.
ORCID: Bailey, Mark M.
Berkland, Cory J.
Venue: Medicinal Research Reviews
Publisher: Wiley
Published: 2008-10-27
Volume: 29
Issue: 1
Pages: 196-212
ISSN: 0198-6325 (ISSN-L)
1098-1128
DOI: 10.1002/med.20140
OpenAlex: W2111564907
Cited by: 302
References: 80
Citations by year: 2026: 8 · 2025: 6 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 13 · 2020: 18 · 2019: 22 · 2018: 12 · 2017: 13 · 2016: 20 · 2015: 19 · 2014: 25 · 2013: 25 · 2012: 20
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Medicinal Research Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: pulmonary drug delivery, nanoparticles, dry powder inhaler, nebulizer, polymeric nanoparticles, polyelectrolyte complexes, liposomes, spray drying, supercritical fluid extraction, precipitation chemistry, solvent extraction, intracellular drug delivery, nanoparticle toxicity
MeSH terms: Administration, Inhalation, Animals, Pharmaceutical Preparations, Humans, Liposomes, Lung, Nebulizers and Vaporizers, Drug Design, Drug Delivery Systems, Nanomedicine, Nanoparticles

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Nanoparticle formulations in pulmonary drug delivery

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