The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index, and 1 are not checked yet.
Multifunctional magnetic nanoparticles for targeted imaging and therapy
Open accessAbstract
Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.
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“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [7]
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Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
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Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
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Metadata
- Authors
- MCCARTHY, J., & WEISSLEDER, R.
- Affiliations
- Harvard University (US)
- Corresponding author
- MCCARTHY, J
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2008-08-17
- Volume
- 60
- Issue
- 11
- Pages
- 1241-1251
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC2583936
- OpenAlex
- W2154964751
- Cited by
- 892
- References
- 92
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 24 · 2021: 33 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 56 · 2016: 57 · 2015: 55 · 2014: 71 · 2013: 88 · 2012: 83
- FWCI
- 46.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (5u54ca119349-05)
- National Heart, Lung, and Blood Institute (U01HL080731)
- National Cancer Institute (U54CA126515, U54 CA-119349)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- magnetic nanoparticles, targeted imaging, theranostics, MRI contrast agents, affinity ligands, phage display, aptamers, immunoglobulins, tumor imaging, atherosclerosis, diabetes mellitus, multifunctional nanomaterials
- MeSH terms
- Animals, Biocompatible Materials, Diagnostic Imaging, Ferric Compounds, Humans, Magnetics, Neoplasms, Drug Delivery Systems, Atherosclerosis, Nanoparticles
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