Cited by 892Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index, and 1 are not checked yet.

Multifunctional magnetic nanoparticles for targeted imaging and therapy

Open access

MCCARTHY, J, WEISSLEDER, R·2008·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2008.03.014PMC PMC2583936

Open this paper in CoChat — free account

Abstract

Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.addr.2008.03.014

Cites

93 of 94 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,796
Applications of Magnetic Nanoparticles in Biomedicine
Bárcena, C., Sra, A. K., & Gao, J. (2009) · Springer eBooks · doi:10.1007/978-0-387-85600-1_20 · Cited by 2,571
The immune response in atherosclerosis: a double-edged sword
Hansson, G. K., & Libby, P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1882 · Cited by 2,220
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971
Self-citation
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716
Self-citation
Delineation of prognostic biomarkers in prostate cancer
Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R. B., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., & Chinnaiyan, A. M. (2001) · Nature · doi:10.1038/35090585 · Cited by 1,675

Flagged first, then by citations

Show all 92 references

Sorted by citations

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., Pogue, B. W., & Hasan, T. G. (2010) · Chemical Reviews · doi:10.1021/cr900300p · Cited by 2,359
Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
Gao, J., Gu, H., & Xu, B. (2009) · Accounts of Chemical Research · doi:10.1021/ar9000026 · Cited by 1,907
Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy
Mahmoudi, M., Sant, S., Wang, B., Laurent, S., & Sen, T. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.006 · Cited by 1,931
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
Omid Veiseh, A., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,854
Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications
Shi, J., Votruba, A. R., Farokhzad, O. C., & Langer, R. (2010) · Nano Letters · doi:10.1021/nl102184c · Cited by 1,651
Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,528
Nanoparticles in the clinic
Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy
Dong, H., Du, S., Zheng, X.-Y., Lyu, G.-M., Sun, L., Li, L.-D., Zhang, P., Zhang, C., & Yan, C. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00091 · Cited by 1,133
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin, M., & Arora, S. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30320 · Cited by 1,148
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H. (2010) · Nano Reviews · doi:10.3402/nano.v1i0.5358 · Cited by 1,112
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,084
Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy
Yu, M. K., Park, J., & Jon, S. (2012) · Theranostics · doi:10.7150/thno.3463 · Cited by 907
Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications
Fadeel, B., & Garcia‐Bennett, A. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.008 · Cited by 811
Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy
Tassa, C., Shaw, S. Y., & Weissleder, R. (2011) · Accounts of Chemical Research · doi:10.1021/ar200084x · Cited by 653
Self-citation
Magnetic Nanoparticles: From Design and Synthesis to Real World Applications
Kudr, J., Haddad, Y., Richtera, L., Heger, Z., Černák, M., Adam, V., & Zítka, O. (2017) · Nanomaterials · doi:10.3390/nano7090243 · Cited by 646
Atrp in the design of functional materials for biomedical applications
Siegwart, D. J., Oh, J. K., & Matyjaszewski, K. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.001 · Cited by 613
Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances
Revia, R. A., & Zhang, M. (2015) · Materials Today · doi:10.1016/j.mattod.2015.08.022 · Cited by 612
A Review of Clinical Translation of Inorganic Nanoparticles
Anselmo, A. C., & Mitragotri, S. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9780-2 · Cited by 509
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
Monodisperse Magnetic Nanoparticles for Theranostic Applications
Ho, D. N., Sun, X., & Sun, S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200090c · Cited by 510
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
Wei, H., Bruns†, O. T., Kaul, M. G., Hansen, E. C., Barch, M., Wiśniowska, A. E., Chen, O., Chen, Y., Li, N., Okada, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620145114 · Cited by 500
From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications
Figuerola, A., Di Corato, R., Manna, L., & Pellegrino, T. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.012 · Cited by 480
Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy
Yallapu, M. M., Othman, S. F., Curtis, E. T., Gupta, B. K., Jaggi, M., & Chauhan, S. C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.028 · Cited by 476
Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy
Li, J., Rao, J., & Pu, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.025 · Cited by 472
Nanoparticles for biomedical imaging
Nune, S. K., Gunda, P., Thallapally, P. K., Lin, Y., Forrest, M. L., & Berkland, C. J. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903229031 · Cited by 456
In vivo degeneration and the fate of inorganic nanoparticles
Feliu, N., Docter, D., Heine, M., del Pino, P., Ashraf, S., Kolosnjaj‐Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00699f · Cited by 446
Iron oxide-based superparamagnetic polymeric nanomaterials: design, preparation, and biomedical application
Oh, J. K., & Park, J. M. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.08.005 · Cited by 427
Cancer theranostics: the rise of targeted magnetic nanoparticles
Cole, A. J., Yang, V. C.-M., & David, A. E. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.03.001 · Cited by 425
Receptor-targeted nanocarriers for therapeutic delivery to cancer
Yu, B., Tai, H.-C., Xue, W., Lee, L. J., & Lee, R. J. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.521200 · Cited by 429
Stabilization and functionalization of iron oxide nanoparticles for biomedical applications
Amstad, E., Textor, M., & Reimhult, E. (2011) · Nanoscale · doi:10.1039/c1nr10173k · Cited by 421
Review—Organic-Inorganic Hybrid Functional Materials: An Integrated Platform for Applied Technologies
Mir, S. H., Nagahara, L. A., Thundat, T. G., Mokarian‐Tabari, P., Furukawa, H., & Khosla, A. (2018) · Journal of The Electrochemical Society · doi:10.1149/2.0191808jes · Cited by 388
Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma
Xin, H., Jiang, X., Gu, J., Sha, X., Chen, L., Law, K., Chen, Y., Wang, X., Jiang, Y., & Fang, X. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.044 · Cited by 392
Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances
Holá, K., Marková, Z., Zoppellaro, G., Tuček, J., & Zbořil, R. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.02.003 · Cited by 377
Nanoparticle Technologies for Cancer Therapy
Alexis, F., Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00477-3_2 · Cited by 384
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo, D. N., Yang, D. H., Moon, H., Lee, J. B., Bae, M. S., Lee, S. C., Lee, W. J., Sun, I., & Kwon, I. K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.064 · Cited by 358
Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation
Choi, H. S., & Frangioni, J. V. (2010) · Molecular Imaging · doi:10.2310/7290.2010.00031 · Cited by 361
Multifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 359
New forms of superparamagnetic nanoparticles for biomedical applications
Xu, C., & Sun, S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.008 · Cited by 349
Progress in functionalization of magnetic nanoparticles for applications in biomedicine
Berry, C. C. (2009) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/22/224003 · Cited by 341
Molecular Nanomedicine Towards Cancer: 111In-Labeled Nanoparticles
Psimadas, D., Georgoulias, P., Valotassiou, V. J., & Loudos, G. K. (2012) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23146 · Cited by 322
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
Tu, Y., Peng, F., Adawy, A., Men, Y., Abdelmohsen, L. K. E. A., & Wilson, D. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00344 · Cited by 321
Synthesis and Biomedical Applications of Multifunctional Nanoparticles
Kim, D., Shin, K., Kwon, S. G., & Hyeon, T. (2018) · Advanced Materials · doi:10.1002/adma.201802309 · Cited by 328
Correlating Physico-Chemical with Toxicological Properties of Nanoparticles: The Present and the Future
Rivera-Gil, P., Oberdörster, G., Elder, A. C. P., Puntes, V., & Parak, W. J. (2010) · ACS Nano · doi:10.1021/nn1025687 · Cited by 314
Nanomaterials for Cancer Therapy and Imaging
Bae, K. H., Chung, H. J., & Park, T. G. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0051-5 · Cited by 320
Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Cole, A. J., David, A. E., Wang, J., Galbán, C. J., Hill, H. L., & Yang, V. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.040 · Cited by 308
Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image‐Guided Approaches
Huang, J., Li, Y., Orza, A., Lu, Q., Guo, P., Wang, L., Yang, L., & Mao, H. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504185 · Cited by 292
Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery
Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.053 · Cited by 301
Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T 1 -Weighted Magnetic Resonance Imaging and Chemotherapy
Shen, Z., Chen, T., Ma, X., Ren, W., Zhou, Z., Zhu, G., Zhang, A., Liu, Y., Song, J., Li, Z., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04924 · Cited by 298
A Synergistically Enhanced T1–T2 Dual‐Modal Contrast Agent
Zhou, Z., Huang, D., Bao, J., Chen, Q., Liu, G., Chen, Z., Chen, X. S., & Gao, J. (2012) · Advanced Materials · doi:10.1002/adma.201203169 · Cited by 294
Magnetic polymer nanocomposites for environmental and biomedical applications
Kalia, S., Kango, S., Kumar, A., Haldorai, Y., Kumari, B., & Kumar, R. (2014) · Colloid & Polymer Science · doi:10.1007/s00396-014-3357-y · Cited by 295
PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics
Perry, J. L., Herlihy, K. P., Napier, M. E., & DeSimone, J. M. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000315 · Cited by 291
Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Trabulo, S. M. D., Cardoso, A. L., Mano, M., & de Lima, M. C. P. (2010) · Pharmaceuticals · doi:10.3390/ph3040961 · Cited by 306
Progress in electrochemical synthesis of magnetic iron oxide nanoparticles
Ramimoghadam, D., Bagheri, S., & Hamid, S. B. A. (2014) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2014.05.015 · Cited by 285
Engineering applications of ferrofluids: A review
Kole, M., & Khandekar, S. (2021) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2021.168222 · Cited by 287
Sol–gel derived organic–inorganic hybrid materials: synthesis, characterizations and applications
Pandey, S., & Mishra, S. B. (2011) · Journal of Sol-Gel Science and Technology · doi:10.1007/s10971-011-2465-0 · Cited by 284
Upconversion nanocomposite for programming combination cancer therapy by precise control of microscopic temperature
Zhu, X., Li, J., Qiu, X., Liu, Y., Feng, W., & Li, F. (2018) · Nature Communications · doi:10.1038/s41467-018-04571-4 · Cited by 277
Iron oxide nanorods as high-performance magnetic resonance imaging contrast agents
Mohapatra, J., Mitra, A., Tyagi, H., Bahadur, D., & Aslam, M. (2015) · Nanoscale · doi:10.1039/c5nr00055f · Cited by 276
Fabrication of cyclodextrin-functionalized superparamagnetic Fe3O4/amino-silane core–shell nanoparticles via layer-by-layer method
Cao, H., He, J., Deng, L., & Gao, X. (2009) · Applied Surface Science · doi:10.1016/j.apsusc.2009.04.199 · Cited by 270
An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery systems
Fonseca‐Santos, B., & Chorilli, M. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.198 · Cited by 272
Folic acid–Pluronic F127 magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications
Lin, J.-J., Chen, J., Huang, S., Ko, J.-H., Wang, Y., Chen, T.-L., & Wang, L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.004 · Cited by 266
Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy
Zhu, L., Zhou, Z., Mao, H. Z., & Yang, L. P. H. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0316 · Cited by 268
Nanoparticle magnetism
Papaefthymiou, G. C. (2009) · Nano Today · doi:10.1016/j.nantod.2009.08.006 · Cited by 264
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors
Larsen, E., Nielsen, T., Wittenborn, T. R., Birkedal, H., Vorup‐Jensen, T., Jakobsen, M. H., Østergaard, L., Horsman, M. R., Besenbacher, F., Howard, K. A., et al. (2009) · ACS Nano · doi:10.1021/nn900330m · Cited by 263
Magnetic core-shell nanoparticles for drug delivery by nebulization
Verma, N. K., Crosbie-Staunton, K., Satti, A., Gallagher, S. A., Ryan, K. B., Doody, T., McAtamney, C., MacLoughlin, R. J., Galvin, P., Burke, C. S., et al. (2013) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-11-1 · Cited by 260
Superparamagnetic nanoarchitectures for disease-specific biomarker detection
Masud, M. K., Na, J., Younus, M., Hossain, M. S. A., Bando, Y., Shiddiky, M. J. A., & Yamauchi, Y. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00174c · Cited by 262
Nanotheranostics for personalized medicine
Mura, S., & Couvreur, P. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.006 · Cited by 568
Engineered Iron-Oxide-Based Nanoparticles as Enhanced T 1 Contrast Agents for Efficient Tumor Imaging
Zhou, Z., Wang, L., Chi, X., Bao, J., Yang, L., Zhao, W., Chen, Z., Wang, X., Chen, X. S., & Gao, J. (2013) · ACS Nano · doi:10.1021/nn305991e · Cited by 252
Mesoporous silicananoparticles for the design of smart delivery nanodevices
Colilla, M., González, B., & Vallet‐Regí, M. (2012) · Biomaterials Science · doi:10.1039/c2bm00085g · Cited by 250
The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources
Cho, S. H., Jones, B. L., & Krishnan, S. (2009) · Physics in Medicine and Biology · doi:10.1088/0031-9155/54/16/004 · Cited by 241
Magnetic particle imaging: from proof of principle to preclinical applications
Knopp, T., Gdaniec, N., & Möddel, M. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa6c99 · Cited by 239
Core–shell hybrid nanogels for integration of optical temperature-sensing, targeted tumor cell imaging, and combined chemo-photothermal treatment
Wu, W., Shen, J., Banerjee, P., & Zhou, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.030 · Cited by 236
Biomedical nanomaterials for imaging-guided cancer therapy
Huang, Y., He, S., Cao, W., Cai, K., & Liang, X. (2012) · Nanoscale · doi:10.1039/c2nr31715j · Cited by 236
Perspective of Fe3O4Nanoparticles Role in Biomedical Applications
Ghazanfari, M. R., Kashefi, M., Shams, S. F., & Jaafari, M. R. (2016) · Biochemistry Research International · doi:10.1155/2016/7840161 · Cited by 235
Magnetic Nanoparticles of Iron Carbide, Iron Oxide, Iron@Iron Oxide, and Metal Iron Synthesized by Laser Ablation in Organic Solvents
Amendola, V., Riello, P., & Meneghetti, M. (2010) · The Journal of Physical Chemistry C · doi:10.1021/jp109371m · Cited by 232
Magnetic Nanoparticles in Magnetic Resonance Imaging and Diagnostics
Rümenapp, C., Gleich, B., & Haase, A. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0711-y · Cited by 246
Ligand density on nanoparticles: A parameter with critical impact on nanomedicine
Alkilany, A. M., Zhu, L., Weller‡, H., Mews, A., Parak, W. J., Barz, M., & Feliu, N. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.05.010 · Cited by 238
The potential for nanoparticle-based drug delivery to the brain: overcoming the blood–brain barrier
Barbu, E., Molnar, E. M., Tsibouklis, J., & Górecki, D. C. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902939143 · Cited by 229
Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles
Ling, D., Hackett, M., & Hyeon, T. (2014) · Nano Today · doi:10.1016/j.nantod.2014.06.005 · Cited by 232
Preparation of core–shell Fe 3 O 4 @poly(dopamine) magnetic nanoparticles for biosensor construction
Martín, M. E., Salazar, P., Villalonga, R., Campuzano, S., Pingarrón, J. M., & González–Mora, J. L. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21171a · Cited by 226
Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
He, X., Gao, J., Gambhir, S. S., & Cheng, Z. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.08.006 · Cited by 229
High-Resolution Single Particle Zeta Potential Characterisation of Biological Nanoparticles using Tunable Resistive Pulse Sensing
Vogel, R., Pal, A. K., Jambhrunkar, S., Patel, P. B., Thakur, S. S., Reátegui, E., Parekh, H. S., Saá, P., Stassinopoulos, A., & Broom, M. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-14981-x · Cited by 225
Multifunctional nanoparticles for targeted delivery of immune activating and cancer therapeutic agents
Feng, J., Liu, X., Li, L., Mallapragada, S. K., Narasimhan, B., & Wang, Q. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.012 · Cited by 224
Monodisperse Au–Fe2C Janus Nanoparticles: An Attractive Multifunctional Material for Triple-Modal Imaging-Guided Tumor Photothermal Therapy
Ju, Y., Zhang, H., Yu, J. X., Tong, S., Tian, N., Wang, Z., Wang, X., Su, X., Chu, X., Lin, J., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04461 · Cited by 219
Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels
Mazuel, F., Espinosa, A., Luciani, N., Reffay, M., Borgne, R. L., Motte, L., Desboeufs, K., Michel, A., Pellegrino, T., Lalatonne, Y., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b02876 · Cited by 217
Metallic nanoparticles: technology overview & drug delivery applications in oncology
Ahmad, M. Z., Akhter, S., Jain, G. K., Rahman, M., Pathan, S. A., Ahmad, F. J., & Khar, R. K. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.498473 · Cited by 219
Cell penetrating peptides: overview and applications to the delivery of oligonucleotides
Hassane, F. S., Saleh, A. F. A., Abes, R., Gait, M. J., & Lebleu, B. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0186-0 · Cited by 219
Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics
Goel, S., England, C. G., Chen, F., & Cai, W. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.08.001 · Cited by 213
99mTc-Bisphosphonate-Iron Oxide Nanoparticle Conjugates for Dual-Modality Biomedical Imaging
de Rosales, R. T. M., Tavaré, R., Glaria, A., Varma, G., Protti, A., & Blower, P. J. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100483k · Cited by 208
Induction of EPC homing on biofunctionalized vascular grafts for rapid in vivo self-endothelialization — A review of current strategies
Avci‐Adali, M., Ziemer, G., & Wendel, H. P. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.10.005 · Cited by 203
PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications
Yallapu, M. M., Foy, S. P., Jain, T. K., & Labhasetwar, V. D. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0260-1 · Cited by 199
Soft Discoidal Polymeric Nanoconstructs Resist Macrophage Uptake and Enhance Vascular Targeting in Tumors
Key, J., Palange, A. L., Gentile, F., Aryal, S., Stigliano, C., Mascolo, D. D., Rosa, E. D., Cho, M., Lee, Y., Singh, J. V., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b04866 · Cited by 195
Surface controlled synthesis of MFe 2 O 4 (M = Mn, Fe, Co, Ni and Zn) nanoparticles and their magnetic characteristics
Mohapatra, J., Mitra, A., Bahadur, D., & Aslam, M. (2012) · CrystEngComm · doi:10.1039/c2ce25957e · Cited by 195
Gadolinium loaded nanoparticles in theranostic magnetic resonance imaging
Liu, Y., & Zhang, N. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.084 · Cited by 199
Luminescent Gold Nanoparticles with pH-Dependent Membrane Adsorption
Yu, M., Zhou, C., Liu, J., Hankins, J. D., & Zheng, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja201930p · Cited by 195
Peptide-based supramolecular hydrogels for local drug delivery
Zhang, Z., Ai, S., Yang, Z., & Li, X. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.010 · Cited by 196
Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality
Soenen, S. J., Himmelreich, U., Nuytten, N., Pisanic, T. R., Ferrari, A., & Cuyper, M. D. (2010) · Small · doi:10.1002/smll.201000763 · Cited by 189
Non-spherical micro- and nanoparticles in nanomedicine
Zhu, X., Vo, C. L.-N., Taylor, M., & Smith, B. R. (2019) · Materials Horizons · doi:10.1039/c8mh01527a · Cited by 191
Optical and Multimodality Molecular Imaging
Jaffer, F. A., Libby, P., & Weissleder, R. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.165530 · Cited by 186
Self-citation
Removal, preconcentration and determination of Mo(VI) from water and wastewater samples using maghemite nanoparticles
Afkhami, A., & Norooz-Asl, R. (2009) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2009.05.024 · Cited by 180

Authors: MCCARTHY, J., & WEISSLEDER, R.
Affiliations: Harvard University (US)
Corresponding author: MCCARTHY, J
ORCID: MCCARTHY, J
WEISSLEDER, R
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2008-08-17
Volume: 60
Issue: 11
Pages: 1241-1251
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2008.03.014
PMC: PMC2583936
OpenAlex: W2154964751
Cited by: 892
References: 92
Citations by year: 2026: 14 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 24 · 2021: 33 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 56 · 2016: 57 · 2015: 55 · 2014: 71 · 2013: 88 · 2012: 83
FWCI: 46.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Institutes of Health (5u54ca119349-05)
National Heart, Lung, and Blood Institute (U01HL080731)
National Cancer Institute (U54CA126515, U54 CA-119349)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: magnetic nanoparticles, targeted imaging, theranostics, MRI contrast agents, affinity ligands, phage display, aptamers, immunoglobulins, tumor imaging, atherosclerosis, diabetes mellitus, multifunctional nanomaterials
MeSH terms: Animals, Biocompatible Materials, Diagnostic Imaging, Ferric Compounds, Humans, Magnetics, Neoplasms, Drug Delivery Systems, Atherosclerosis, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multifunctional magnetic nanoparticles for targeted imaging and therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks