Weissleder, Ralph

A clearer vision for in vivo imaging

Weissleder, R. (2001) · Nature Biotechnology

Advanced Fluorescence Microscopy TechniquesOptical Imaging and Spectroscopy Techniques

Cited by 3,839

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine

Cardiac Fibrosis and RemodelingAtherosclerosis and Cardiovascular Diseases

Cited by 2,300

Identification of splenic reservoir monocytes and their deployment to inflammatory sites

Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science

Immune cells in cancerAtherosclerosis and Cardiovascular Diseases

Cited by 2,221

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 2,043

Noninvasive detection of clinically occult lymph-node metastases in prostate cancer

Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine

Prostate Cancer Diagnosis and TreatmentMRI in cancer diagnosis

Cited by 1,971

Restoration of p53 function leads to tumour regression in vivo

Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 1,820

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

Engelman, J. A., Chen, L., Tan, X., Crosby, K., Guimaraes, A. R., Upadhyay, R., Maira, M., McNamara, K., Perera, S. A., Song, Y., et al. (2008) · Nature Medicine

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,330

Molecular Imaging

Weissleder, R., & Mahmood, U. (2001) · Radiology

Medical Imaging Techniques and ApplicationsRadiopharmaceutical Chemistry and Applications

Cited by 1,315

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Rodell, C. B., Arlauckas, S. P., Cuccarese, M. F., Garris, C. S., Li, R., Ahmed, M. S., Kohler, R. H., Pittet, M. J., & Weissleder, R. (2018) · Nature Biomedical Engineering

Immune cells in cancerImmunotherapy and Immune Responses

Cited by 1,099

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

Robbins, C. S., Hilgendorf, I., Weber, G. F., Theurl, I., Iwamoto, Y., Figueiredo, J.-L., Gorbatov, R., Sukhova, G. K., Gerhardt, L. M. S., Smyth, D., et al. (2013) · Nature Medicine

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 1,041

Macrophages Facilitate Electrical Conduction in the Heart

Hulsmans, M., Clauss, S., Xiao, L., Aguirre, A. D., King, K. R., Hanley, A., Hucker, W. J., Wülfers, E. M., Seemann, G., Courties, G., et al. (2017) · Cell

Cardiac electrophysiology and arrhythmiasConnexins and lens biology

Cited by 1,011

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., et al. (2010) · Cell

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 1,001

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

Garris, C. S., Arlauckas, S. P., Kohler, R. H., Trefny, M. P., Garren, S., Piot, C., Engblom, C., Pfirschke, C., Siwicki, M., Gungabeesoon, J., et al. (2018) · Immunity

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 966

Multifunctional magnetic nanoparticles for targeted imaging and therapy

MCCARTHY, J., & WEISSLEDER, R. (2008) · Advanced Drug Delivery Reviews

Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug Delivery

Cited by 892

Therapeutic siRNA silencing in inflammatory monocytes in mice

Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T. I., Donahoe, J. S., Courties, G., Lee, K. M., Kim, J. I., Markmann, J. F., Marinelli, B., et al. (2011) · Nature Biotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 839

Imaging macrophages with nanoparticles

Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials

Nanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery

Cited by 809

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo

Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 806

Chronic variable stress activates hematopoietic stem cells

Heidt, T., Sager, H. B., Courties, G., Dutta, P., Iwamoto, Y., Zaltsman, A., von zur Muhlen, C., Bode, C., Fricchione, G. L., Denninger, J., et al. (2014) · Nature Medicine

Hematopoietic Stem Cell TransplantationStress Responses and Cortisol

Cited by 803

In vivo molecular target assessment of matrix metalloproteinase inhibition

Bremer, C., Tung, C.-H., & Weissleder, R. (2001) · Nature Medicine

Protease and Inhibitor MechanismsOptical Imaging and Spectroscopy Techniques

Cited by 726

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

Arlauckas, S. P., Garris, C. S., Kohler, R. H., Kitaoka, M., Cuccarese, M. F., Yang, K. S., Miller, M. A., Carlson, J. C., Freeman, G. J., Anthony, R. M., et al. (2017) · Science Translational Medicine

Cancer Immunotherapy and BiomarkersImmune cells in cancer

Cited by 669

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Sebastián, C., Zwaans, B. M. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., et al. (2012) · Cell

Sirtuins and Resveratrol in MedicineCancer, Hypoxia, and Metabolism

Cited by 660

Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy

Tassa, C., Shaw, S. Y., & Weissleder, R. (2011) · Accounts of Chemical Research

Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic Nanoparticles

Cited by 653

Chip–NMR biosensor for detection and molecular analysis of cells

Lee, H., Sun, E., Ham, D., & Weissleder, R. (2008) · Nature Medicine

Advanced NMR Techniques and ApplicationsNMR spectroscopy and applications

Cited by 621

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., et al. (2018) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 610