The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery
Open accessAbstract
Polysaccharides are gaining increasing attention as components of stimuli-responsive drug delivery systems, particularly since they can be obtained in a well characterized and reproducible way from the natural sources. Ionic polysaccharides can be readily crosslinked to render hydrogel networks sensitive to a variety of internal and external variables, and thus suitable for switching drug release on-off through diverse mechanisms. Hybrids, composites and grafted polymers can reinforce the responsiveness and widen the range of stimuli to which polysaccharide-based systems can respond. This review analyzes the state of the art of crosslinked ionic polysaccharides as components of delivery systems that can regulate drug release as a function of changes in pH, ion nature and concentration, electric and magnetic field intensity, light wavelength, temperature, redox potential, and certain molecules (enzymes, illness markers, and so on). Examples of specific applications are provided. The information compiled demonstrates that crosslinked networks of ionic polysaccharides are suitable building blocks for developing advanced externally activated and feed-back modulated drug delivery systems.
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Cites
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Cited by
Kocak, G., Tuncer, C., & Bütün, V. (2017) · Polymer Chemistry · doi:10.1039/c6py01872f · Cited by 1,189
Benalaya, I., Alves, G., Lopes, J., & Silva, L. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021322 · Cited by 482
Qu, J., Zhao, X., Ma, P. X., & Guo, B. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.018 · Cited by 468
Samanta, H. S., & Ray, S. K. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.09.004 · Cited by 293
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Metadata
- Authors
- Alvarez-Lorenzo, C., Blanco-Fernandez, B., Puga, A. M., & Concheiro, A.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 65
- Issue
- 9
- Pages
- 1148-1171
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2019729163
- Cited by
- 532
- References
- 146
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
