Repurposing of statins via inhalation to treat lung inflammatory conditions
Open accessAbstract
Despite many therapeutic advancements over the past decade, the continued rise in chronic inflammatory lung diseases incidence has driven the need to identify and develop new therapeutic strategies, with superior efficacy to treat these diseases. Statins are one class of drug that could potentially be repurposed as an alternative treatment for chronic lung diseases. They are currently used to treat hypercholesterolemia by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, that catalyses the rate limiting step in the mevalonate biosynthesis pathway, a key intermediate in cholesterol metabolism. Recent research has identified statins to have other protective pleiotropic properties including anti-inflammatory, anti-oxidant, muco-inhibitory effects that may be beneficial for the treatment of chronic inflammatory lung diseases. However, clinical studies have yielded conflicting results. This review will summarise some of the current evidences for statins pleiotropic effects that could be applied for the treatment of chronic inflammatory lung diseases, their mechanisms of actions, and the potential to repurpose statins as an inhaled therapy, including a detailed discussion on their different physical-chemical properties and how these characteristics could ultimately affect treatment efficacies. The repurposing of statins from conventional anti-cholesterol oral therapy to inhaled anti-inflammatory formulation is promising, as it provides direct delivery to the airways, reduced risk of side effects, increased bioavailability and tailored physical-chemical properties for enhanced efficacy.
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Statins exhibit poor aqueous solubility and chemical instability, factors that can limit drug availability at the site of infection and compromise biological activity.
“This is particularly relevant given that statins exhibit poor aqueous solubility and chemical instability, factors that can limit drug availability at the site of infection and compromise biological activity [128, 129].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [128]
Section 4.1 (page unavailable) identifies low water solubility and chemical instability in solution as formulation problems for simvastatin. Sections 4.0 and 4.2 discuss how statin properties affect delivery and anti-inflammatory efficacy in the airways. The claim extends those specific observations to statins generally and to availability at a site of infection, which the cited passages do not establish. (LLM, conf=0.86)
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e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7 · see citing works
“This is particularly relevant given that statins exhibit poor aqueous solubility and chemical instability, factors that can limit drug availability at the site of infection and compromise biological activity [128, 129].”
- Authors
- Bradbury, P., Traini, D., Ammit, A. J., Young, P. M., & Ong, H. X.
- Affiliations
- University of Technology Sydney (AU)
- The University of Sydney (AU)
- Corresponding author
- Ong, Hui Xin
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 133
- Pages
- 93-106
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2807483316
- Cited by
- 38
- References
- 187
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- OPUS - Open Publications of UTS Scholars (University of Technology Sydney) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- statins, drug repurposing, inhalation therapy, chronic inflammatory lung disease, pleiotropy, anti-inflammatory activity, antioxidant activity, HMG-CoA reductase inhibition, mevalonate biosynthesis, physicochemical properties, bioavailability, airway drug delivery
- MeSH terms
- Administration, Inhalation, Humans, Inflammation, Lung Diseases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Drug Repositioning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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