The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Why nanoparticles prefer liver macrophage cell uptake in vivo
Abstract
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to accumulate in diseased tissues. However, most nanoparticles end up in the liver macrophages regardless of nanoparticle design after administration. In this review, we describe the interactions of liver macrophage cells with nanoparticles. The liver macrophage has significant advantages in interacting with circulating nanoparticles over most target cells and tissues in the body. We describe these advantages in this article. Understanding these advantages will enable the development of strategies to overcome liver macrophages and deliver nanoparticles to targeted diseased tissues effectively. Ultimately, these approaches will increase the therapeutic efficacy and diagnostic signal of nanoparticles.
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Cited by
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Metadata
- Authors
- Ngo, W., Ahmed, S., Blackadar, C., Bussin, B., Ji, Q., Mladjenovic, S. M., Sepahi, Z., & Chan, W. C. W.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 185
- Pages
- 114238
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W4220844669
- Cited by
- 256
- References
- 15
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ngo, W., Ahmed, S., Blackadar, C., Bussin, B., Ji, Q., Mladjenovic, S. M., Sepahi, Z., & Chan, W. C. W. (2022). Why nanoparticles prefer liver macrophage cell uptake in vivo. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2022.114238
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