Cited by 42Metabolism and Genetic DisordersAmino Acid Enzymes and MetabolismBiochemical and Molecular Research

On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome

Treberg, Jason R., Brosnan, Margaret E., Watford, Malcolm, Brosnan, John T.·2010·Advances in Enzyme Regulation

Integrity signals

Registry

Crossref · 10.1016/j.advenzreg.2009.10.029

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59 of 59 references verified0 citation errors · 0 not checkable

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  • Krebs found that GDH operates at close to equilibrium in vitro, and some evidence indicates GDH may be reversible in some tissues in vivo.

    “Krebs found that GDH operates at close to equilibrium in vitro, and some evidence indicates that GDH may be reversible in some tissues in vivo (112, 126).”

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Authors
Treberg, J. R., Brosnan, M. E., Watford, M., & Brosnan, J. T.
Affiliations
  • Buck Institute for Research on Aging (US)
  • Memorial University of Newfoundland (CA)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Brosnan, John T.
Venue
Advances in Enzyme Regulation
Publisher
Elsevier BV
Published
2010
Volume
50
Issue
1
Pages
34-43
ISSN
0065-2571 (ISSN-L)
OpenAlex
W2068204639
Cited by
41
References
59
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 2 · 2018: 5 · 2017: 1 · 2016: 2 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Advances in Enzyme Regulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords
glutamate dehydrogenase, enzyme reversibility, hyperammonemia, hyperinsulinism/hyperammonemia syndrome, ammonia metabolism, enzyme kinetics
MeSH terms
Animals, Brain, Glutamate Dehydrogenase, Humans, Hyperinsulinism, Intestine, Small, Isoenzymes, Kidney, Liver, Oxidation-Reduction, Syndrome, Tissue Distribution, Muscle, Skeletal, Hyperammonemia, Insulin-Secreting Cells

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