On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Krebs found that GDH operates at close to equilibrium in vitro, and some evidence indicates GDH may be reversible in some tissues in vivo.
“Krebs found that GDH operates at close to equilibrium in vitro, and some evidence indicates that GDH may be reversible in some tissues in vivo (112, 126).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [126]
Cites
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871 · see citing works
Uptake and Metabolism of Plasma Glutamine by the Small Intestine
Windmueller, H. G., & Spaeth, A. E. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42329-6 · Cited by 791 · see citing works
Ammonia production in muscle and other tissues: the purine nucleotide cycle.
Lowenstein, J. M. (1972) · Physiological Reviews · doi:10.1152/physrev.1972.52.2.382 · Cited by 697 · see citing works
Stanley, C. A., Lieu, Y. K., Hsu, B. Y. L., Burlina, A., Greenberg, C. R., Hopwood, N. J., Perlman, K., Rich, B. H., Zammarchi, E., & Poncz, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805073381904 · Cited by 676 · see citing works
Regulation of Glutaminase Activity and Glutamine Metabolism
Curthoys, N. P., & Watford, M. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001025 · Cited by 643 · see citing works
Self-citationThe glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
McKenna, M. C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21444 · Cited by 385 · see citing works
The metabolic fate of 13N-labeled ammonia in rat brain.
Cooper, A. J. L., McDonald, J. M., Gelbard, A. S., Gledhill, R. F., & Duffy, T. E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50550-0 · Cited by 353 · see citing works
Isolation and metabolic characteristics of rat and chicken enterocytes
Watford, M., Lund, P., & Krebs, H. A. (1979) · Biochemical Journal · doi:10.1042/bj1780589 · Cited by 252 · see citing works
Self-citationRose, W. C., Smith, L., Womack, M., & Shane, M. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56650-3 · Cited by 177 · see citing works
McKenna, M. C., Tildón, J. T., Stevenson, J., Boatright, R., & Huang, S. C.-C. (1994) · Developmental Neuroscience · doi:10.1159/000111351 · Cited by 170 · see citing works
Substrate oxidation by the portal drained viscera of fed piglets
Stoll, B., Burrin, D. G., Henry, J. F., Yu, H., Jahoor, F., & Reeds, P. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e168 · Cited by 160 · see citing works
Effects of ischaemia on metabolite concentrations in rat liver
Brosnan, J. T., Krebs, H. A., & Williamson, D. H. (1970) · Biochemical Journal · doi:10.1042/bj1170091 · Cited by 159 · see citing works
Self-citationThe Structure of Apo Human Glutamate Dehydrogenase Details Subunit Communication and Allostery
Smith, T. J., Schmidt, T., Fang, J., Wu, J., Siuzdak, G. E., & Stanley, C. A. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00161-4 · Cited by 130 · see citing works
Foster, G. L., Schoenheimer, R., & Rittenberg, D. (1939) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)73844-1 · Cited by 129 · see citing works
Plaitakis, A., & Zaganas, I. V. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10054 · Cited by 123 · see citing works
Short-term metabolic fate of [13N]ammonia in rat liver in vivo.
Cooper, A. J. L., Nieves, E., Coleman, A. E., Filc-DeRicco, S., & Gelbard, A. S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75751-2 · Cited by 121 · see citing works
Stanley, C. A. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.10.013 · Cited by 119 · see citing works
Untangling the glutamate dehydrogenase allosteric nightmare
Smith, T. J., & Stanley, C. A. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.07.007 · Cited by 106 · see citing works
A syndrome of congenital hyperinsulinism and hyperammonemia
WEINZIMER, S. A., Stanley, C. A., Berry, G. T., Yudkoff, M., Tuchman, M., & THORNTON, P. S. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70256-7 · Cited by 104 · see citing works
Disorders of glutamate metabolism
Kelly, A. T., & Stanley, C. A. (2001) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.1040 · Cited by 100 · see citing works
Mavrothalassitis, G., Tzimagiorgis, G., Mitsialis, S. A., Zannis, V. I., Plaitakis, A., Papamatheakis, J. D., & Moschonas, N. Κ. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3494 · Cited by 95 · see citing works
Carobbio, S., Ishihara, H., Fernández‐Pascual, S., Bartley, C., Martín-del-Río, R., & Maechler, P. (2004) · Diabetologia · doi:10.1007/s00125-003-1306-2 · Cited by 91 · see citing works
Propionic acidemia: mutation update and functional and structural effects of the variant alleles
Desviat, L. R., Pérez, B., Pérez‐Cerdá, C., Rodríguez‐Pombo, P., Clavero, S., & Ugarte, M. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.08.001 · Cited by 90 · see citing works
Glutamate dehydrogenase activation and ammonia formation by rat kidney mitochondria.
Schoolwerth, A. C., Nazar, B. L., & LaNoue, K. F. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34596-9 · Cited by 88 · see citing works
New Insights into the Compartmentation of Glutamate and Glutamine in Cultured Rat Brain Astrocytes
McKenna, M. C., Tildón, J. T., Stevenson, J., & Huang, X. (2007) · Developmental Neuroscience · doi:10.1159/000111431 · Cited by 87 · see citing works
Zammarchi, E., Filippi, L., Novembre, E. M., & Donati, M. A. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90262-0 · Cited by 86 · see citing works
Stanley, C. A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462aa · Cited by 85 · see citing works
The urea cycle: Teaching intermediary metabolism in a physiological setting
Watford, M. (2003) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.2003.494031050249 · Cited by 76 · see citing works
Self-citationYorifuji, T., Muroi, J., Uematsu, A., Hiramatsu, H., & Momoi, T. (1999) · Human Genetics · doi:10.1007/s004390050990 · Cited by 74 · see citing works
Short-term metabolic fate of 13N-labeled glutamate, alanine, and glutamine(amide) in rat liver.
Cooper, A. J. L., Nieves, E., Rosenspire, K. C., Filc-DeRicco, S., Gelbard, A. S., & Brusilow, S. W. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37750-0 · Cited by 70 · see citing works
N‐Carbamylglutamate protects patients with decompensated propionicaciduria from hyperammonaemia
Gebhardt, B. R., Dittrich, S., Parbel, S., Vlaho, S., Matsika, O., & Böhles, H. (2005) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-5260-7 · Cited by 69 · see citing works
Li, C., Matter, A. M., Kelly, A. T., Petty, T. J., Najafi, H., MacMullen, C., Daikhin, Y., Nissim, I. B., Lazarow, A., Kwagh, J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600994200 · Cited by 68 · see citing works
Hyperinsulinism and Hyperammonemia Syndrome: Report of Twelve Unrelated Patients
de Lonlay, P., Benelli, C., Fouque, F., Ganguly, A. A., Aral, B., Dionisi‐Vici, C., Touati, G., Heinrichs, C., Rabier, D., Kamoun, P., et al. (2001) · Pediatric Research · doi:10.1203/00006450-200109000-00010 · Cited by 67 · see citing works
Studies of Hepatic Glutamine Metabolism in the Perfused Rat Liver with 15N-Labeled Glutamine
Nissim, I., Brosnan, M. E., Yudkoff, M., Nissim, I. B., & Brosnan, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28958 · Cited by 61 · see citing works
Self-citationRestoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate
Caldovic, L., Morizono, H., Daikhin, Y., Nissim, I., McCarter, R., Yudkoff, M., & Tuchman, M. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.047 · Cited by 58 · see citing works
Brosnan, J. T., Brosnan, M. E., Charron, R. J., & Nissim, I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16199 · Cited by 51 · see citing works
Self-citationSodium valproate-induced hyperammonemia in the rat: Role of the kidney
Warter, J., Imler, M., Marescaux, C., Chabrier, G., Rumbach, L., Micheletti, G., & Krieger, J. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90327-8 · Cited by 46 · see citing works
The human GLUD2 glutamate dehydrogenase: Localization and functional aspects
Zaganas, I. V., Kanavouras, K., Mastorodemos, V. C., Latsoudis, H., Spanaki, C., & Plaitakis, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.03.001 · Cited by 41 · see citing works
Renal ammonium production—une vue canadienne
Brosnan, J. T., Lowry, M., Vinay, P., Gougoux, A., & Halperin, M. L. (1987) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y87-084 · Cited by 40 · see citing works
Self-citationHuijmans, J. G. M., Durán, M., de Klerk, J. B. C., Rovers, M. J., & Scholte, H. R. (2000) · PEDIATRICS · doi:10.1542/peds.106.3.596 · Cited by 35 · see citing works
The Distribution of Glutamate Dehydrogenase in Rat Tissues
Herzfeld, A. (1972) · Enzyme · doi:10.1159/000459668 · Cited by 32 · see citing works
Pathways of Ammonia Metabolism in the Intact Functioning Kidney of the Dog*
Stone, W. J., & Pitts, R. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105607 · Cited by 30 · see citing works
Failure of glutamate dehydrogenase system to predict oxygenation state of human skeletal muscle
Katz, A., SPENCER, M. K., & Sahlin, K. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.1.c26 · Cited by 29 · see citing works
Glutamine catabolism by heart muscle. Properties of phosphate-activated glutaminase
NELSON, D. S., Rumsey, W. L., & Erecińska, M. (1992) · Biochemical Journal · doi:10.1042/bj2820559 · Cited by 28 · see citing works
Metabolism of [13N]ammonia in rat lung
Cooper, A. J. L., & Freed, B. R. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.04.013 · Cited by 25 · see citing works
Glutamine cycling in isolated working rat heart
Cohen, D. M., Guthrie, P. H., Gao, X., Sakai, R., & Taegtmeyer, H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00539.2002 · Cited by 23 · see citing works
Anno, T., Uehara, S., Katagiri, H., Ohta, Y., Ueda, K., Mizuguchi, H., Moriyama, Y., Oka, Y., & Tanizawa, Y. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2003 · Cited by 21 · see citing works
Hahn, P., Taller, M., & Chan, H. (2009) · Biology of the Neonate · doi:10.1159/000242814 · Cited by 18 · see citing works
Madej, M., Lundh, T., & Lindberg, J. E. (2002) · Neonatology · doi:10.1159/000064153 · Cited by 15 · see citing works
Animals are Dependent on Preformed α‐Amino Nitrogen as an Essential Nutrient
Katagiri, M., & Nakamura, M. (2002) · IUBMB Life · doi:10.1080/15216540211467 · Cited by 14 · see citing works
Relationship of pNH3 of tubular cells to renal production of ammonia
Pilkington, L. A., Welch, J., & Pitts, R. F. (1965) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1965.208.6.1100 · Cited by 12 · see citing works
Reappraisal of the 20th-century version of amino acid metabolism
Katagiri, M., & Nakamura, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.219 · Cited by 11 · see citing works
Demonstration of glutamate dehydrogenase isozymes in beef heart mitochondria.
McDaniel, H. G., Bösing‐Schneider, R., Jenkins, R. L., RASCHED, I. R., & Sund, H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36179-3 · Cited by 9 · see citing works
Ihara, K., Miyako, K., Ishimura, M., Kuromaru, R., Wang, H. ‐., Yasuda, K., & Hara, T. (2005) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-0084-z · Cited by 8 · see citing works
Is there really any evidence indicating that animals synthesize glutamate?
Katagiri, M., & Nakamura, M. (1999) · Biochemical Education · doi:10.1016/s0307-4412(98)00233-7 · Cited by 7 · see citing works
From metabolic cycles to compartmentation: another first for Krebs
Halestrap, A. P., & Brosnan, J. T. (2008) · Biochemical Journal · doi:10.1042/bj20080524 · Cited by 6 · see citing works
Self-citationEffect of an ammonia load on the kidney near-equilibrium systems in the rat in vivo.
Vinay, P. (1976) · PubMed · Cited by 1 · see citing works
(2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2005 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
From Krebs to clinic: glutamine metabolism to cancer therapy
Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works
The multifaceted contributions of mitochondria to cellular metabolism
Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935 · see citing works
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works
“Krebs found that GDH operates at close to equilibrium in vitro, and some evidence indicates that GDH may be reversible in some tissues in vivo (112, 126).”
BackgroundMetabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Spinelli, J. B., Yoon, H., Ringel, A. E., Jeanfavre, S., Clish, C. B., & Haigis, M. C. (2017) · Science · doi:10.1126/science.aam9305 · Cited by 468 · see citing works
Glutamate: a truly functional amino acid
Brosnan, J. T., & Brosnan, M. E. (2012) · Amino Acids · doi:10.1007/s00726-012-1280-4 · Cited by 395 · see citing works
Self-citationCooper, A., & Jeitner, T. (2016) · Biomolecules · doi:10.3390/biom6020016 · Cited by 223 · see citing works
Li, C., Chen, P., Palladino, A., Narayan, S. B., Russell, L. K., Sayed, S. U., Xiong, G., Chen, J., Stokes, D., Butt, Y. M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123638 · Cited by 179 · see citing works
Wang, Y.-Q., Wang, H.-L., Xu, J., Tan, J., Fu, L., Wang, J., Zou, T., Sun, D., Gao, Q., Chen, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02951-4 · Cited by 169 · see citing works
The Role of Glutamine Synthetase and Glutamate Dehydrogenase in Cerebral Ammonia Homeostasis
Cooper, A. J. L. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0803-4 · Cited by 114 · see citing works
The Role of Glutamate Dehydrogenase in Mammalian Ammonia Metabolism
Spanaki, C., & Plaitakis, A. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9285-4 · Cited by 108 · see citing works
l-Glutamate nutrition and metabolism in swine
Hou, Y., & Wu, G. (2018) · Amino Acids · doi:10.1007/s00726-018-2634-3 · Cited by 97 · see citing works
Treberg, J. R., Clow, K. A., Greene, K. A., Brosnan, M. E., & Brosnan, J. T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00028.2010 · Cited by 69 · see citing works
Self-citation13N as a tracer for studying glutamate metabolism
Cooper, A. J. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.11.011 · Cited by 62 · see citing works
Botman, D., Tigchelaar, W., & Noorden, C. J. F. V. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414549071 · Cited by 58 · see citing works
Karaca, M., Frigerio, F., & Maechler, P. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.024 · Cited by 52 · see citing works
Discovery and development of small molecule modulators targeting glutamine metabolism
Li, L., Meng, Y., Li, Z., Dai, W., Xu, X. J., Xiao-ling, B., & Bian, J. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.11.066 · Cited by 49 · see citing works
Yang, Y., He, P., Hou, Y., Liu, Z., Zhang, X., & Li, N. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154075 · Cited by 35 · see citing works
Physiological Role of Glutamate Dehydrogenase in Cancer Cells
Moreno‐Sánchez, R., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., Pacheco-Velázquez, S. C., Robledo‐Cadena, D. X., Padilla-Flores, J. A., Saavedra, E., & Rodríguez‐Enríquez, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00429 · Cited by 34 · see citing works
Stanley, C. A. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.11.017 · Cited by 34 · see citing works
Intertissue Differences for the Role of Glutamate Dehydrogenase in Metabolism
Treberg, J. R., Banh, S., Pandey, U., & Weihrauch, D. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0998-z · Cited by 28 · see citing works
Self-citationIngebrigtsen, I. A., Berge, G. M., Ruyter, B., Kjær, M. A., Mørkøre, T., Sørensen, M., & Gjøen, T. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.06.036 · Cited by 26 · see citing works
Romanov, V., Whyard, T. C., Bonala, R., Johnson, F., & Grollman, A. P. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0646-5 · Cited by 26 · see citing works
Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease
Pan, C., Mao, S., Xiong, Z., Chen, Z., & Xu, N. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175733 · Cited by 23 · see citing works
Down-regulation of Hepatic Urea Synthesis by Oxypurines
Nissim, I., Horyn, O., Nissim, I. B., Daikhin, Y., Caldovic, L., Barcelona, B., Cervera, J., Tuchman, M., & Yudkoff, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209023 · Cited by 21 · see citing works
Implications of GI function for gas exchange, acid–base balance and nitrogen metabolism
Taylor, J. R., Cooper, C. A., & Mommsen, T. P. (2010) · Fish physiology · doi:10.1016/s1546-5098(10)03006-2 · Cited by 19 · see citing works
Mitochondrial targets in hyperammonemia: Addressing urea cycle function to improve drug therapies
Moedas, M. F., Simões, R. J., & Silva, M. F. B. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116034 · Cited by 17 · see citing works
Mansilla, W. D., Silva, K. E., Zhu, C., Nyachoti, C. M., Htoo, J. K. K., Cant, J. P., & de Lange, C. F. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy076 · Cited by 16 · see citing works
Hypoglycemia in the toddler and child
Langdon, D. R., Stanley, C. A., & Sperling, M. A. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00030-5 · Cited by 14 · see citing works
Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome
Boodhansingh, K. E., Rosenfeld, E., Lord, K., Adzick, N. S., Bhatti, T. R., Ganguly, A. A., León, D. D. D., & Stanley, C. A. (2022) · Hormone Research in Paediatrics · doi:10.1159/000526203 · Cited by 11 · see citing works
Mao, L., Hong, X., Xu, L., Wang, X., Liu, J., Wang, H., Qian, Y., Zhao, J., & Jia, R. (2022) · Journal of Oncology · doi:10.1155/2022/5498743 · Cited by 9 · see citing works
Lifting the veil on tumor metabolism: A GDH1-focused perspective
Zhou, S., Wu, H., Chen, Y., Lv, J., Chen, S., Yu, H., Shi, T., Wang, X., & Xiao, L. (2025) · iScience · doi:10.1016/j.isci.2025.112551 · Cited by 8 · see citing works
The physicochemical and nutritional profile of high protein yak milk powder
Wang, P., Wei, Y., Yertai, Y., Li, W., & Mamet, T. (2025) · International Dairy Journal · doi:10.1016/j.idairyj.2025.106195 · Cited by 6 · see citing works
Kelly, A. T., Palladino, A., & Stanley, C. A. (2012) · Frontiers in diabetes · doi:10.1159/000334513 · Cited by 5 · see citing works
Glutamate Dehydrogenase as a Promising Target for Hyperinsulinism Hyperammonemia Syndrome Therapy
Bian, Y., Hou, W., Chen, X., Fang, J., Xu, N., & Ruan, B. H. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210825105342 · Cited by 5 · see citing works
Glutamate formation via the leucine-to-glutamate pathway of rat pancreas
Schachter, D., & Buteau, J. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00394.2013 · Cited by 5 · see citing works
Hypoglycemia in the Toddler and Child
Wolfsdorf, J. I., & Stanley, C. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00023-3 · Cited by 5 · see citing works
Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism
Fukui, K., Takahashi, T., Matsunari, H., Uchikura, A., Watanabe, M., Nagashima, H., Ishihara, N., Kakuma, T., Watanabe, Y., Yamashita, Y., et al. (2022) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12540 · Cited by 4 · see citing works
Gariani, K., Klauser, A., Vargas, M. I., Lazeyras, F., & Tran, C. (2022) · Brain Sciences · doi:10.3390/brainsci12030389 · Cited by 1 · see citing works
Mansilla, W. D. (2013) · The Atrium (University of Guelph) · Cited by 1 · see citing works
Watford, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00062-1 · Cited by 1 · see citing works
Self-citationCarobbio, S., Vetterli, L., Frigerio, F., Karaca, M., & Maechler, P. (2012) · Frontiers in diabetes · doi:10.1159/000334518
BindingDB (2021) · UC San Diego · doi:10.7270/q2n87f26
- Authors
- Treberg, J. R., Brosnan, M. E., Watford, M., & Brosnan, J. T.
- Affiliations
- Buck Institute for Research on Aging (US)
- Memorial University of Newfoundland (CA)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Brosnan, John T.
- Venue
- Advances in Enzyme Regulation
- Publisher
- Elsevier BV
- Published
- 2010
- Volume
- 50
- Issue
- 1
- Pages
- 34-43
- ISSN
- 0065-2571 (ISSN-L)
- OpenAlex
- W2068204639
- Cited by
- 41
- References
- 59
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 2 · 2018: 5 · 2017: 1 · 2016: 2 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Enzyme Regulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- glutamate dehydrogenase, enzyme reversibility, hyperammonemia, hyperinsulinism/hyperammonemia syndrome, ammonia metabolism, enzyme kinetics
- MeSH terms
- Animals, Brain, Glutamate Dehydrogenase, Humans, Hyperinsulinism, Intestine, Small, Isoenzymes, Kidney, Liver, Oxidation-Reduction, Syndrome, Tissue Distribution, Muscle, Skeletal, Hyperammonemia, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review