The DOI matches its Crossref record; 264 of the 266 references it cites were found in a registry or an index.
Optical biosensors: a decade in review
Open accessAbstract
Miniaturized, specific, rapid response and economical biosensors are finding applications in biotechnology, environmental studies, agriculture, food inspection and safety, disease diagnosis and medical utilities. Of the many categories of biosensors, optical biosensors have brought about an extra edge in sensing applications due to their selective, rapid and extremely sensitive measurements. Biosensors are analytical tools used to detect specific analytes such as cholesterol, urea, etc. having biomolecules such as nucleic acids, proteins, carbohydrates as key element for detecting these analytes along with a transducer and a data analysis and visualization tool. In case of optical biosensors the analyte is detected using light with either label based or label free techniques. In this paper some of the marked advances in the last decade in the field of optical biosensors have been reviewed with an emphasis on their fabrication approaches and growing application areas. Along with some of the carefully selected article on new developments in optical biosensors through the last decade, a brief historical review of optical biosensors since the breakthrough in optical biosensors in 1970s has also been presented. Another focus of the current review is the classification of biosensors, typical structures along with emerging developments in optical biosensing that are likely to impact the current decade. Major application areas and emerging applications through the last decade have been outlined to present a clear picture on the versatility of optical biosensors. Finally, the review also considers the challenges and future of emerging optical biosensing technologies in the current decade.
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“Label-based optical techniques are colorimetric or fluorometric methods [172] which have demonstrated great promise for monitoring of metabolites, glucose, and other biomarkers in sweat, tears, or interstitial fluid, providing valuable insights for disease management and preventive healthcare [173,174].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [172]
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“Integration of these materials into flexible substrates and microfluidic devices has facilitated the development of wearable devices that are lightweight, conformable, and comfortable for long-term use [172].”
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“Optical techniques detect changes in reflectance, absorbance, scat - tering, or turbidity, whereas mass-based technique identifies analyte-binding interactions through changes in mass measured using techniques like quartz crystal microbalance or surface acoustic wave devices (Singh et al. 2023).”
Boddu, S., Vasimalla, Y., Singh, R., & Kumar, S. (2026) · Optics & Laser Technology · doi:10.1016/j.optlastec.2026.116536
Photonic Sensors Based on Molecularly Imprinted Polymers for Cancer Biomarker Detection
Silva, A. T., Gersen, H., Pereira, C. M. D. M., & Ribeiro, J. A. (2026) · Journal of Analysis and Testing · doi:10.1007/s41664-026-00512-z
Biosensors as Powerful Tools for Campylobacter Spp. Detection
Khan, J. A., Husain, F., Ahmad, I., Neyaz, L., Elbanna, K., & Abulreesh, H. (2026) · Advances in microbiology · doi:10.2478/am-2026-0011
“Optical biosensors provide rapid, highly sensitive detection by measuring optical signal changes generated by target recognition and include SPR, TIRF, diffractive optics, and FRET-based systems (Yang et al. 2013; Singh et al. 2023).”
Sallai, I., Varga, D. S., Csippa, B., Béres, B., Szittner, Z., Székács, I., Dér, A., Bonyár, A., & Horvath, R. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.141027
Bionanofactory-Enabled Point-of-Care Biosensors
Saravanan, D., Rajamohan, R., Sundaram, T., & Mohan, M. (2026) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-92-1553-9_9
Optical biosensors for cancer diagnosis and monitoring
Saputra, H. A., Sahin, M. A. Z., & Hartati, Y. W. (2026) · Clinica Chimica Acta · doi:10.1016/j.cca.2026.122895
The Digital Pillbox: Evaluating the Impact of Digital Health on Medication Compliance
Patil, P. Y. (2026) · Asian Journal of Pharmaceutical Research · doi:10.52711/2231-5691.2026.00071
Toxins produced by microorganisms and algae in food
Valado, A., & Pereira, L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29080-0.00016-7
Mukhangaliyeva, L., Omirzakova, A., Nurlankyzy, M., Ashirkhan, R., Yendibay, B., Issatayeva, A., Adilova, Z., Blanc, W., Tan, C. K. L., Tosi, D., et al. (2026) · Biosensors · doi:10.3390/bios16110612
Metadata
- Authors
- Singh, A. K., Mittal, S., Das, M., Saharia, A., & Tiwari, M.
- Affiliations
- Manipal University Jaipur (IN)
- Vellore Institute of Technology University (IN)
- Corresponding author
- Tiwari, Manish
- Venue
- Alexandria Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2023-03
- Volume
- 67
- Pages
- 673-691
- ISSN
- 1110-0168 (ISSN-L)
- OpenAlex
- W4320474624
- Cited by
- 292
- References
- 266
- Citations by year
- 2026: 64 · 2025: 108 · 2024: 87 · 2023: 33
- FWCI
- 26.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Alexandria Engineering Journal (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
- Keywords
- optical biosensors, biosensor fabrication, label-free detection, biosensor classification, biosensor applications, biosensor miniaturization, disease diagnosis, food safety, environmental monitoring
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