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Cited by 134Potassium and Related DisordersThyroid Disorders and TreatmentsCardiac electrophysiology and arrhythmias

Effects of potassium supplementation on the recovery of thyrotoxic periodic paralysis

Lu, Kuo-Cheng, Hsu, Yu-Juei, Chiu, Jainn-Shiun, Hsu, Yaw-Don, Lin, Shih-Hua·2004·The American Journal of Emergency Medicine
DOI 10.1016/j.ajem.2004.09.016
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Abstract

Potassium supplements have been recommended to hasten recovery and prevent cardiopulmonary complications in patients with thyrotoxic periodic paralysis (TPP). However, this recommendation has not yet been proven efficacious. Thirty-two patients with acute attacks of TPP over a 3-year-period were divided into 2 groups. Group A (n = 12) was a control group treated with normal saline infusion 125 mL/hr only. Group B (n = 20) received intravenous KCl administration at a rate of 10 mmol/hr in normal saline 125 mL/hr. During the attack and for 6 hours after muscle recovery, hemodynamics were continuously recorded and muscle strength and plasma K(+) concentration were measured hourly. The sex, age, muscle strength, thyroid function, biochemical values including plasma K(+) levels, as well as the time from attack to therapy (3.6 +/- 1.6 v 3.3 +/- 1.0 hr) were not significant between the 2 groups. However, recovery time was significantly shorter in the KCl group than the control (6.3 +/- 3.8 v 13.5 +/- 7.5 hr, P < .01). Rebound hyperkalemia greater than 5.5 mmol/L occurred in 40% patients receiving KCl. The dose of KCl administered and peak K(+) concentration were positively correlated (r = 0.85, P < .001). In conclusion, KCl therapy proves to help the recovery of paralysis in TPP associated with rebound hyperkalemia. KCl supplementation should be given as small as possible (<10 mmol/hr) to avoid rebound hyperkalemia unless there are cardiopulmonary complications.

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  • One prospective study compared treatment with intravenous potassium chloride to normal saline infusion and found a shorter recovery time with use of potassium (6.3 vs. 13.5 hours).

    “One prospective study compared treatment with intravenous potassium chloride to normal saline infusion and found a shorter recovery time with use of potassium (6.3 vs. 13.5 hours) [42].”

    From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [42]

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Authors
Lu, K.-C., Hsu, Y.-J., Chiu, J.-S., Hsu, Y.-D., & Lin, S.-H.
Affiliations
  • Fu Jen Catholic University (TW)
  • Tri-Service General Hospital (TW)
Corresponding author
Lin, Shih-Hua
ORCID
Venue
The American Journal of Emergency Medicine
Publisher
Elsevier BV
Published
2004-11
Volume
22
Issue
7
Pages
544-547
ISSN
0735-6757 (ISSN-L)
DOI
10.1016/j.ajem.2004.09.016
OpenAlex
W2168158278
Cited by
134
References
21
Citations by year
2026: 3 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 4 · 2012: 14
FWCI
3.92
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Emergency Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
thyrotoxic periodic paralysis, potassium chloride supplementation, muscle recovery, hyperthyroidism, plasma potassium, hemodynamics
MeSH terms
Adult, Age Factors, Blood Pressure, Electrocardiography, Follow-Up Studies, Heart Rate, Humans, Hyperkalemia, Hypokalemia, Male, Middle Aged, Muscle Contraction, Paralysis, Potassium, Potassium Chloride, Sex Factors, Sodium Chloride, Thyroid Crisis, Thyroid Gland, Time Factors, Muscle, Skeletal, Recovery of Function

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