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Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
Open accessAbstract
Men have a shorter life expectancy compared with women but the underlying factor(s) are not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD. Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in blood cells, is associated with all-cause mortality and an increased risk of non-hematological tumors and that LOY could be induced by tobacco smoking. We tested here a hypothesis that men with LOY are more susceptible to AD and show that LOY is associated with AD in three independent studies of different types. In a case-control study, males with AD diagnosis had higher degree of LOY mosaicism (adjusted odds ratio = 2.80, p = 0.0184, AD events = 606). Furthermore, in two prospective studies, men with LOY at blood sampling had greater risk for incident AD diagnosis during follow-up time (hazard ratio [HR] = 6.80, 95% confidence interval [95% CI] = 2.16-21.43, AD events = 140, p = 0.0011). Thus, LOY in blood is associated with risks of both AD and cancer, suggesting a role of LOY in blood cells on disease processes in other tissues, possibly via defective immunosurveillance. As a male-specific risk factor, LOY might explain why males on average live shorter lives than females.
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“However, there is conflicting evidence regarding the impact of CH on Alzheimer’s disease (AD).5,10”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [10]
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“Mosaic chromosomal alterations, including loss of the Y chromosome (LOY), are strongly associated with cardiovascular disease, stroke, and dementia risk [34,44,45].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [45]
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Citations
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Self-citationClonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Self-citationPotential for primary prevention of Alzheimer's disease: an analysis of population-based data
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., & Brayne, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70136-x · Cited by 2,466
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234
Self-citationRole of Genes and Environments for Explaining Alzheimer Disease
Gatz, M., Reynolds, C. A., Fratiglioni, L., Johansson, B., Mortimer, J. A., Berg, S., Fiske, A., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.168 · Cited by 1,798
21st-Century Hazards of Smoking and Benefits of Cessation in the United States
Jha, P., Ramasundarahettige, C., Landsman, V., Rostron, B., Thun, M., Anderson, R. N., McAfee, T., & Peto, R. (2013) · New England Journal of Medicine · doi:10.1056/nejmsa1211128 · Cited by 1,767
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Escott-Price, V., Bellenguez, C., Wang, L.-S., Choi, S.-H., Harold, D., Jones, L., Holmans, P., Gerrish, A., Vedernikov, A., Richards, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094661 · Cited by 1,398
Self-citationSimard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265
Boeva, V., Popova, T. G., Kevin Bleakley, A., Chiche, P., Cappo, J., Schleiermacher, G., Janoueix‐Lerosey, I., Delattre, O., & Barillot, E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr670 · Cited by 1,012
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
Genin, E., Hannequin, D., Wallon, D., Sleegers, K., Hiltunen, M., Combarros, O., Bullido, M. J., Engelborghs, S., De Deyn, P., Berr, C., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.52 · Cited by 714
Self-citation(2003) · Neuroepidemiology · doi:10.1159/000072920 · Cited by 672
Detectable clonal mosaicism from birth to old age and its relationship to cancer
Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2271 · Cited by 594
Detectable clonal mosaicism and its relationship to aging and cancer
Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2270 · Cited by 589
Mosaic Copy Number Variation in Human Neurons
McConnell, M. J., Lindberg, M. R., Brennand, K. J., Piper, J. C., Voet, T., Cowing-Zitron, C., Shumilina, S., Lasken, R. S., Vermeesch, J. R., Hall, I. M., et al. (2013) · Science · doi:10.1126/science.1243472 · Cited by 551
Forsberg, L. A., Rasi, C., Malmqvist, N., Davies, H., Pasupulati, S., Pakalapati, G., Sandgren, J., de Ståhl, T. D., Zaghlool, A., Giedraitis, V., et al. (2014) · Nature Genetics · doi:10.1038/ng.2966 · Cited by 460
Self-citationImmune surveillance in the central nervous system
Ousman, S. S., & Kubes, P. (2012) · Nature Neuroscience · doi:10.1038/nn.3161 · Cited by 457
Contribution of Alzheimer disease to mortality in the United States
James, B. D., Leurgans, S. E., Hebert, L. E., Scherr, P. A., Yaffe, K. S., & Bennett, D. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000240 · Cited by 377
Lind, L., Fors, N., Hall, J., Marttala, K., & Stenborg, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184769.22061.da · Cited by 364
Self-citationCataldo, J. K., Prochaska, J. J., & Glantz, S. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1240 · Cited by 356
Change of Human Chromosome Count Distributions with Age: Evidence for a Sex Difference
Jacobs, P. A., BRUNTON, M., Brown, W. M. C., Doll, R., & Goldstein, H. (1963) · Nature · doi:10.1038/1971080a0 · Cited by 294
Genetic insights in Alzheimer's disease
Bettens, K., Sleegers, K., & Van Broeckhoven, C. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70259-4 · Cited by 290
Ahmad, A. S., Ormiston‐Smith, N., & Sasieni, P. D. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.606 · Cited by 275
Age-associated aneuploidy: Loss of Y chromosome from human bone marrow cells with aging
Pierre, R. V., & Hoagland, H. C. (1972) · Cancer · doi:10.1002/1097-0142(197210)30:4 · Cited by 265
Smoking is associated with mosaic loss of chromosome Y
Dumanski, J. P., Rasi, C., Lönn, M., Davies, H., Ingelsson, M., Giedraitis, V., Lannfelt, L., Magnusson, P. K. E., Lindgren, C. M., Morris, A. P., et al. (2014) · Science · doi:10.1126/science.1262092 · Cited by 250
Self-citationConvergent genetic and expression data implicate immunity in Alzheimer's disease
International Genomics of Alzheimer's Disease Consortium (IGAP), Jones, L., Lambert, J., Wang, L., Choi, S., Harold, D., Vedernikov, A., Escott‐Price, V., Stone, T., Richards, A., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.05.1757 · Cited by 199
Self-citationAnalysis ofPTCH/SMO/SHH pathway genes in medulloblastoma
Zurawel, R. H., Allen, C., CHIAPPA, S. A., Cato, W., Biegel, J. A., Cogen, P. H., de Sauvage, F. J., & Raffel, C. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200001)27:1 · Cited by 191
Bacterial Infection and Alzheimer's Disease: A Meta-Analysis
Maheshwari, P., & Eslick, G. D. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140621 · Cited by 183
Age-related somatic structural changes in the nuclear genome of human blood cells
Forsberg, L. A., Rasi, C., Razzaghian, H. R., Pakalapati, G., Waite, L., Thilbeault, K. S., Ronowicz, A., Wineinger, N. E., Tiwari, H. K., Boomsma, D., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.009 · Cited by 176
Self-citationCancer cells preferentially lose small chromosomes
Duijf, P. H. G., Schultz, N. D., & Benezra, R. (2012) · International Journal of Cancer · doi:10.1002/ijc.27924 · Cited by 175
Loss of the Y chromosome from normal and neoplastic bone marrows
(1992) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870050112 · Cited by 167
Case, L. K., Wall, E. H., Dragon, J. A., Saligrama, N., Krementsov, D. N., Moussawi, M., Zachary, J. F., Huber, S. A., Blankenhorn, E. P., & Teuscher, C. (2013) · Genome Research · doi:10.1101/gr.156703.113 · Cited by 150
A study of middle-aged men with particular reference to risk factors for cardiovascular disease.
Hedstrand, H. (1975) · PubMed · Cited by 149
Bonnefond, A., Skrobek, B., Lobbens, S., Eury, E., Thuillier, D., Cauchi, S., Lantieri, O., Balkau, B., Riboli, E., Marre, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2700 · Cited by 139
Cell Cycle Activation and Aneuploid Neurons in Alzheimer's Disease
Arendt, T. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8262-0 · Cited by 138
Herpes simplex infection and the risk of Alzheimer’s disease: A nested case-control study
Lövheim, H., Gilthorpe, J., Johansson, A., Eriksson, S., Hallmans, G., & Elgh, F. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.07.157 · Cited by 136
Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129
EADI consortium, G. C., Lambert, J.-C., Grenier-Boley, B., Harold, D., Zelenika, D., Chouraki, V, Kamatani, Y., Sleegers, K., Ikram, M. A., Hiltunen, M., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.14 · Cited by 129
Self-citationMissense variant in TREML2 protects against Alzheimer's disease
Benítez, B. A., Jin, S. C., Guerreiro, R. J., Graham, R., Lord, J., Harold, D. H., Sims, R., Lambert, J., Gibbs, J. R., Brás, J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.010 · Cited by 126
Self-citationNowinski, G. P., Dyke, D. L. V., Tilley, B., Jacobsen, G. K., Babu, V. R., Worsham, M. J., Wilson, G. N., & Weiss, L. (1990) · Europe PMC (PubMed Central) · Cited by 125
Y chromosome loss in male patients with primary biliary cirrhosis
Lleò, A., Oertelt‐Prigione, S., Bianchi, I., Caliari, L., Finelli, P., Miozzo, M. R., Lazzari, R., Floreani, A., Donato, F., Colombo, M., et al. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.12.008 · Cited by 117
Why Men Die Younger: Causes of Mortality Differences by Sex
Kalben, B. B. (2001) · Cited by 105
Loss of Y Chromosome in Peripheral Blood of Colorectal and Prostate Cancer Patients
Noveski, P., Madjunkova, S., Stefanovska, E. S., Matevska-Geshkovska, N., Kuzmanovska, M., Dimovski, A. J., & Plaseska‐Karanfilska, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146264 · Cited by 102
Genomics and Genetics of Human and Primate Y Chromosomes
Hughes, J. F., & Rozen, S. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163855 · Cited by 100
Persani, L., Bonomi, M., Lleò, A., Pasini, S. M., Civardi, F., Bianchi, I., Campi, I., Finelli, P., Miozzo, M. R., Castronovo, C., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.011 · Cited by 92
Wong, A. K., Fang, B., Zhang, L., Guo, X., Lee, S. B., & Schreck, R. R. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2008-132-1329-lotyca · Cited by 78
New data shed light on Y‐loss‐related pathogenesis in myelodysplastic syndromes
Ganster, C., Kämpfe, D., Jung, K., Braulke, F., Shirneshan, K., Machherndl‐Spandl, S., Suessner, S., Bramlage, C. P., Legler, T. J., Koziolek, M. J., et al. (2015) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22282 · Cited by 57
Kalben, B. B. (2000) · North American Actuarial Journal · doi:10.1080/10920277.2000.10595939 · Cited by 52
Y chromosome structural and functional changes in human malignant diseases
Bianchi, N. O. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.02.001 · Cited by 50
Forsberg, L. A., Absher, D., & Dumanski, J. P. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101322 · Cited by 44
Self-citationMolecular genetic evidence of Y chromosome loss in male patients with hematological disorders
ZHANG, L.-J., Shin, E. S., Zhong-xing, Y. U., & Shi-bo, L. I. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200711020-00012 · Cited by 43
Chapman, J., Rees, E., Harold, D. H., Ivanov, D. K., Gerrish, A., Sims, R., Hollingworth, P., Stretton, A., Holmans, P., Owen, M. J., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds476 · Cited by 34
Wiktor, A. E., Dyke, D. L. V., Hodnefield, J. M., Eckel‐Passow, J. E., & Hanson, C. A. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.05.002 · Cited by 30
Human Y-chromosome variation and male dysfunction
de Carvalho, C. M. B., & dos Santos, F. R. (2005) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000014 · Cited by 21
Male breast cancer, age and sex chromosome aneuploidy
Jacobs, P. A., Maloney, V. K., Cooke, R., Crolla, J. A., Ashworth, A., & Swerdlow, A. J. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.577 · Cited by 20
Score, J., Chase, A., Forsberg, L. A., Feng, L., Waghorn, K., Jones, A. V., Rasi, C., Linch, D. C., Dumanski, J. P., Gale, R. E., et al. (2015) · Leukemia · doi:10.1038/leu.2015.13 · Cited by 18
Self-citationVeiga, L. C. D. S., Bérgamo, N. A., Reis, P. P., Kowalski, L. P., & Rogatto, S. R. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500004 · Cited by 14
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Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Mechanisms of sex differences in Alzheimer’s disease
Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376
Genetic predisposition to mosaic Y chromosome loss in blood
Thompson, D. J., The Kidney Cancer GWAS Meta-Analysis Project, Genovese, G., Halvardson, J., Ulirsch, J. C., Wright, D. J., Terao, C., Davidsson, O. B., Day, F. R., Sulem, P., et al. (2019) · Nature · doi:10.1038/s41586-019-1765-3 · Cited by 340
Self-citationHematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
Sano, S., Horitani, K., Ogawa, H., Halvardson, J., Chavkin, N. W., Wang, Y., Sano, M., Mattisson, J., Hata, A., Danielsson, M., et al. (2022) · Science · doi:10.1126/science.abn3100 · Cited by 277
Self-citationMosaicism in health and disease — clones picking up speed
Forsberg, L. A., Gisselsson, D., & Dumanski, J. P. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.145 · Cited by 261
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Metadata
- Authors
- Dumanski, J. P., Lambert, J.-C., Rasi, C., Giedraitis, V., Davies, H., Grenier-Boley, B., Lindgren, C. M., Campion, D., Dufouil, C., Pasquier, F., Amouyel, P., Lannfelt, L., Ingelsson, M., Kilander, L., Lind, L., & Forsberg, L. A.
- Affiliations
- Uppsala University (SE)
- Inserm (FR)
- Broad Institute (US)
- Corresponding author
- Dumanski, Jan P.
- Forsberg, Lars A.
- ORCID
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 98
- Issue
- 6
- Pages
- 1208-1219
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC4908225
- OpenAlex
- W2403642712
- Cited by
- 266
- References
- 65
- Citations by year
- 2026: 35 · 2025: 42 · 2024: 33 · 2023: 33 · 2022: 22 · 2021: 33 · 2020: 19 · 2019: 22 · 2018: 14 · 2017: 10 · 2016: 3
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (WT098017, 086596, 086596/Z/08/Z, WT064890, WT090532)
- Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
- Agence Nationale de la Recherche (ANR-11-LABX-0009)
- Cancerfonden
- Hjärt-Lungfonden
- Vetenskapsrådet
- Akademiska Sjukhuset
- Uppsala Universitet
- Science for Life Laboratory
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- Y chromosome mosaicism, Alzheimer's disease, sex differences in mortality, blood cells, cancer risk, immune surveillance, smoking, all-cause mortality
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Longitudinal Studies, Male, Middle Aged, Mosaicism, Prognosis, Prospective Studies, Risk Factors, Case-Control Studies, Polymorphism, Single Nucleotide, Chromosomes, Human, Y
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