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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid

Open access
Ighodaro, O.M., Akinloye, O.A.·2018·Alexandria Journal of Medicine
DOI 10.1016/j.ajme.2017.09.001
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Abstract

The body encloses a complex antioxidant defence grid that relies on endogenous enzymatic and non-enzymatic antioxidants. These molecules collectively act against free radicals to resist their damaging effects to vital biomolecules and ultimately body tissues. Based on their response to general free radical invasion, they can be categorized into first, second, third and even fourth line defense antioxidants. The role and effectiveness of the first line defense antioxidants which basically include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) is important and indispensable in the entire defense strategy of antioxidants, especially in reference to super oxide anion radical (*O2) which is perpetually generated in normal body metabolism, particularly through the mitochondrial energy production pathway (MEPP). A lot has been published concerning antioxidants and their significance in preventing oxidative stress and the attendant cellular damage, howbeit with paucity of awareness on the fundamental role of SOD, CAT and GPX. The present review tends to articulate important information on SOD, CAT and GPX as first line defense antioxidant enzymes.

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Metadata

Authors
Ighodaro, O. M., & Akinloye, O. A.
Venue
Alexandria Journal of Medicine
Publisher
Informa UK Limited
Published
2018-12-01
Volume
54
Issue
4
Pages
287-293
ISSN
  • 2090-5068 (ISSN-L)
  • 2090-5076
DOI
10.1016/j.ajme.2017.09.001
OpenAlex
W2768499679
Cited by
3,939
References
6
FWCI
105.25
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)

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CoChat. (2026). Citation check: First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. https://app.cochat.ai/papers/10.1016/j.ajme.2017.09.001
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Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine. https://doi.org/10.1016/j.ajme.2017.09.001

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.