The DOI matches its Crossref record; 32 of the 36 references it cites were found in a registry or an index.
Population-Based Incidence of Uveal Melanoma in Various Races and Ethnic Groups
Abstract
Purpose To investigate racial/ethnic differences in the development of uveal malignant melanoma in a large population-based study.Design Observational cross-sectional study.Methods With the 1992 to 2000 data that was provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program, we calculated age-adjusted incidence rates of uveal melanoma in various racial/ethnic groups (black, Asian and Pacific Islander, Hispanic, and non-Hispanic white). In addition, we calculated the standard incidence ratio (risk ratio) and 95% confidence interval to describe the differences within these racial/ethnic groups.Results From 1992 to 2000, there were a total of 1352 uveal melanomas that were diagnosed in 11 Surveillance, Epidemiology, and End Results registries with known racial/ethnic groups. The annual age-adjusted incidence (per million population) of uveal melanoma was 0.31 (black), 0.38 (Asian), 1.67 (Hispanic), and 6.02 (non-Hispanic white). The difference in the incidence of uveal melanoma between each racial/ethnic group was highly statistically significant, with the exception of the black versus the Asian population in which there was no statistically significant difference.Conclusion The relative risk of uveal melanoma was 1.2 for Asian and Pacific Islander patients, 5.4 for Hispanic patients, and 19.2 for non-Hispanic white patients as compared with the black patients. If the non-Hispanic white population and the Hispanic population were combined, then the overall white:black ratio was 18:1.
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“Incidentally, melanoma is not only associated with UV light exposure but also with European ancestry, occurring at very low rates in Africans, African Americans, and even light-skinned Asians (32)(33)(34).”
From Evidence for recent, population-specific evolution of the human mutation rate (2015) · cites this paper as [33]
In the citing paper
“Melanoma incidence in admixed Hispanics is strongly correlated with European ancestry (33)(34)(35).”
From Evidence for recent, population-specific evolution of the human mutation rate (2015) · cites this paper as [33]
Citations
Cites
Rodríguez‐Sains, R. S., Bart, R. S., Kopf, A. W., & Hölzle, E. (1979) · Cited by 1,287
Ophthalmic Pathology: An Atlas and Textbook
(1953) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1953.tb96223.x · Cited by 555
Epidemiologic aspects of uveal melanoma
Egan, K. M., Seddon, J. M., Glynn, R. J., Gragoudas, E. S., & Albert, D. M. (1988) · Survey of Ophthalmology · doi:10.1016/0039-6257(88)90173-7 · Cited by 528
Incidence of uveal melanoma in the United States: 1973–1997
Singh, A. D., & Topham, A. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00078-2 · Cited by 517
Racial/ethnic patterns of cancer in the United States, 1988-1992.
Miller, B.-A., Kolonel, L. N., Bernstein, L., Young, J. L., Swanson, G., West, D. W., Key, C., Liff, J. M., Glover, C. S., & Alexander, G. A. (1996) · Cited by 500
Melanomas of the Eye and Other Noncutan eous Sites: Epidemiologic Aspects
Scotto, J., Fraumeni, J. F., & Lee, J. (1976) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/56.3.489 · Cited by 382
Cress, R. D., & Holly, E. A. (1997) · Cancer Causes & Control · doi:10.1023/a:1018432632528 · Cited by 296
Conjunctival melanoma: is it increasing in the United States?
Yu, G., Hu, D.-N., McCormick, S. A., & Finger, P. T. (2003) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)02288-2 · Cited by 227
Self-citationPROGNOSIS OF MALIGNANT MELANOMAS OF THE CHOROID AND CILIARY BODY
Paul, E. V., PARNELL, B. L., & Fraker, M. (1962) · International Ophthalmology Clinics · doi:10.1097/00004397-196206000-00007 · Cited by 220
Incidence of uveal melanoma in Sweden from 1960 to 1998.
Bergman, L., Seregard, S., Nilsson, B. R., Ringborg, U. K., Lundell, G. E. F., & Ragnarsson-Olding, B. K. (2002) · PubMed · Cited by 157
Research works printed but not linked: 4
- Phillpotts, 1995, Uveal melanomas in black patients, J Natl Med Assoc, 87, 709
- Gallagher, 1985, Risk factors for ocular melanoma, J Natl Cancer Inst, 74, 775
- Perez-Stable, 1995, Use of Spanish surnames to identify Latinos, J Natl Cancer Inst Monogr, 18, 11
- Cress, 1997, Incidence of cutaneous melanoma among non-Hispanic whites, Hispanics, Asians, and blacks, Cancer Causes Control, 8, 246
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Harris, K. (2014) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/010314
“European ancestry, occurring at very low rates in Africans, African Americans, and even lightskinned Asians [32, 33, 34].”
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Harrie, R. P., & Kendall, C. J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7082-3_159
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Rose, K. (2017) · UWSpace (University of Waterloo)
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Parulan, M. A., Amrith, S., Young, S. M., Ting, E., Wu, B., Nga, M. E., & Sundar, G. (2019) · Springer eBooks · doi:10.1007/978-981-13-3798-7_62
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Patiño-Calla, K., Quezada, G., & Goicochea-Arévalo, R. (2022) · Gaceta Mexicana de Oncología · doi:10.24875/j.gamo.22000009
Prevalence of Choroidal Melanoma in a Hill Population of Northern India
Arora, D., Sharma, A., Sharma, D., Tiwari, B., Kumar, A., Gupta, K., Mehra, R., Arora, A., & Sharma, D. (2021) · International Journal of Ophthalmology & Visual Science · doi:10.11648/j.ijovs.20210604.19
González-Godínez, S., Ortiz-Morales, G., Domínguez‐Varela, I. A., Gomez-Elizondo, D. E., Perez-Ramos, E., Estrada-Hernández, C., Corral, R., Zamorano-Gómez, O., Shields, C. L., Dalvin, L. A., et al. (2022) · Revista Mexicana de Oftalmología · doi:10.24875/rmo.m22000236
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Ortiz‐Urda, S., Ho, W. W.-S., & Lee, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-59128-0_11
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“Uveal melanoma(UM) is the most prevalent intraocular malignancy in adults, with an incidence of 6 per mil - lion in non-Hispanic whites [1] and 0.3–0.6 per million among Asians [2–4].”
InfluentialSensing surface tension for evaluating circulating tumor cell transiting behaviors at narrow vessels
Fan, L., Ma, D., Wu, Z., Zhang, L., Qian, X., Liu, Y., & Ren, J. (2025) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2025.116599
Uveal Melanoma: Epidemiologic Aspects
Soto, H. J., Seregard, S., & Singh, A. D. (2025) · Springer eBooks · doi:10.1007/978-3-031-81354-2_5
Role of miRNA in adult ocular tumorigenesis
Romani, A., Melloni, E., Lodi, G., Bompan, F., Foschi, R., Zauli, E., Pozza, E., Secchiero, P., Zauli, G., Previati, M., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1459761
Precision prognostic model for uveal melanoma: nomogram prediction and comparison with AJCC system
Wu, W., Zhu, J., Wu, Y., Li, D., Liu, R., Zheng, Y., Deng, Q., & Yuan, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-03212-9
“The incidence of UM is significantly higher in non-Hispanic white populations compared to other ethnicities [10, 11].”
Eye melanoma: Epidemiology and risk factors
Mujawar, S., Vijayasarathi, D., Annam, T., Deshpande, T., Prabhune, A., Deshpande, A., & Prajapati, B. G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27541-8.00007-9
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Basu, B., Rahaman, M., & Prajapati, B. G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27541-8.00013-4
Şener, H., Bansal, R., Shields, J. A., & Shields, C. L. (2025) · Eye · doi:10.1038/s41433-025-04055-y
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26402040
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26755420
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26755429
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26401859
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26755426
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26755432
Sun, Y., Wu, J., Zhang, Q., Wang, P., Zhang, J., & Yuan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26755423
Zhang, C., Park, J. K., Zhao, M. Y., Nicola, M. D., & Williams, B. K. (2026) · Ocular Oncology and Pathology · doi:10.1159/000551696
“Black (African American) and Hispanic (Latino) patients were combined into one group as a priori because choroidal melanoma is uncommon in these populations [1].”
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Lever, M., Kreis, S. H., Flühs, D., Guberina, M., Stuschke, M., Bechrakis, N. E., & Stang, A. (2026) · Cancer Epidemiology · doi:10.1016/j.canep.2026.103099
Sepúlveda, S. A., Luna, C., Labbé, E., Manquez, M. E., Vinés, E., Garretón, R., Roa, J. C., Genova, A. D., Moraga, C., Cerpa, L. C., et al. (2026) · Ocular Oncology and Pathology · doi:10.1159/000553241
Association of Income with Enucleation Likelihood and Survival in Uveal Melanoma
Krick, M., & McCannel, T. A. (2026) · Ophthalmic Epidemiology · doi:10.1080/09286586.2026.2734503
Metadata
- Authors
- Hu, D.-N., Yu, G.-P., McCormick, S. A., Schneider, S., & Finger, P. T.
- Affiliations
- New York Eye and Ear Infirmary (US)
- New York Medical College (US)
- Corresponding author
- Hu, Dan-Ning
- Venue
- American Journal of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 140
- Issue
- 4
- Pages
- 612.e1-612.e8
- ISSN
- 0002-9394 (ISSN-L)
- OpenAlex
- W2061857205
- Cited by
- 238
- References
- 36
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 17 · 2023: 17 · 2022: 16 · 2021: 15 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 14 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 17 · 2012: 11
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- uveal melanoma, racial and ethnic differences, cancer incidence, age-adjusted incidence, Hispanic population, Asian and Pacific Islander populations, Black population, non-Hispanic whites, SEER database, relative risk
- MeSH terms
- Cross-Sectional Studies, Ethnicity, Female, Humans, Male, Melanoma, Risk Factors, United States, Uveal Neoplasms, Incidence, SEER Program, Racial Groups
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