Obstructive sleep apnea and orthodontics: An American Association of Orthodontists White Paper
Abstract
The Board of Trustees of the American Association of Orthodontists asked a panel of medical and dental experts in sleep medicine and dental sleep medicine to create a document designed to offer guidance to practicing orthodontists on the suggested role of the specialty of orthodontics in the management of obstructive sleep apnea. This White Paper presents a summary of the Task Force's findings and recommendations.
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Mandibular advancement appliances (MAAs) can reduce AHI, as concluded by the American Society of Orthodontists' White Paper.
“The main outcome index, AHI, validated the conclusion of the American Society of Orthodontists’ White Paper [26] that MAA can reduce AHI.”
From Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances (2025) · cites this paper as [26]
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“These parameters include vertical growth, steep mandibular plane angle, long and narrow face, mandibular retrognathism, narrow and deep palate, anterior open bite and lower hyoid position.(14) However, they emphasize that the strength of the relationship of these parameters with development of OSA requires further exp…”
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“Especially, given that AH may predispose children to sleep-disordered breathing [1], screening for this condition is advisable during treatment planning [20].”
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“The airway volumetric increase after maxillary advancement can benefit the OSA management in growing subjects [29].”
BackgroundSelf-citationBariani, R. C. B., Bigliazzi, R., Medda, M. G., Micieli, A. P. R., Tufik, S., Fujita, R. R., de Mello, C. B., & Moreira, G. A. (2023) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2023.10.011 · Cited by 14 · see citing works
Ronsivalle, V., Leonardi, R. M., Lagravère, M. O., Flores‐Mir, C., Grippaudo, C., Bonetti, G. A., & Giudice, A. L. (2024) · Journal of Dentistry · doi:10.1016/j.jdent.2024.104934 · Cited by 14 · see citing works
Self-citationObstructive sleep apnea: What is an orthodontist’s role?
Kazmierski, R. H. (2024) · Progress in Orthodontics · doi:10.1186/s40510-024-00524-4 · Cited by 14 · see citing works
“The American Association of Orthodontists (AAO) white paper on obstructive sleep apnea (OSA) and orthodontics stands as the definitive statement on this subject [1].”
InfluentialRangarajan, H., Padmanabhan, S., Ranganathan, S., & �Kailasam, V. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02483-0 · Cited by 14 · see citing works
“These appliances work by holding the mandible and the associated tissues forward, thereby increasing the caliber of the upper airway [6].”
BackgroundKim, K., Lee, K., Kim, J., Cho, H.-N., Yoon, H. J., & Kim, S. (2022) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2021.02.028 · Cited by 13 · see citing works
Ishida, E., Kunimatsu, R., Medina, C. C., Iwai, K., Miura, S., Tsuka, Y., & Tanimoto, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247539 · Cited by 13 · see citing works
Shen, Y., Li, X., Feng, X., Yu, L., Weng, L., Zhang, C., Shang, Y., & Lin, J. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03328-w · Cited by 13 · see citing works
“As revealed by recent research, OSHAS patients are getting younger, i.e., an increasing number of adolescents are subjected to narrowed airways [13–15].”
BackgroundAnalysis of nasal airway symmetry and upper airway changes after rapid maxillary expansion
DiCosimo, C. J., Alsulaiman, A. A., Shah, C., Motro, M., Will, L. A., & Parsi, G. K. (2021) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2020.06.038 · Cited by 15 · see citing works
Liu, Y., Chen, W., Wei, Y., Zhang, G., Zhang, X., Sharhan, H. M., & Cao, B. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02580-w · Cited by 13 · see citing works
“obstructive sleep apnea-hypopnea syndrome (OSAHS), craniofacial deformities, arrhythmia, and increased blood pressure [1].”
BackgroundVidigal, M. T. C., Mesquita, C. M., de Oliveira, M. N., Vieira, W. D. A., Blumenberg, C., Nascimento, G. G., Pithon, M. M., & Paranhos, L. R. (2022) · European Journal of Orthodontics · doi:10.1093/ejo/cjac003 · Cited by 12 · see citing works
Mattos, C. T., Dole, L., Júnior, S. L. M., Cury-Saramago, A. D. A., Bianchi, J., Oh, H., Evangelista, K., Valladares‐Neto, J., Ruellas, A. C. D. O., Prieto, J. C., et al. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.105689 · Cited by 12 · see citing works
The effects of rapid maxillary expansion on persistent pediatric snoring post-tonsillectomy
Bariani, R. C. B., Bigliazzi, R., Guimarães, T. M., Tufik, S. B., Moreira, G. A., & Fujita, R. R. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02724-w · Cited by 14 · see citing works
“Supporting evidence suggests that maxillary constriction and mandibular retrusion predispose children to snoring and OSA [11, 12].”
BackgroundObstructive sleep apnea and early orthodontic intervention: How early is early?
Kandasamy, S. (2024) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2023.12.005 · Cited by 13 · see citing works
Rana, A., Raut, A., & Mathur, A. (2023) · Cureus · doi:10.7759/cureus.48682 · Cited by 12 · see citing works
“Untreated sleep apnea has been reported to cause morbid effects on the affected individual’s health [3].”
BackgroundMagalhães, M. C. M. M., Normando, D., Soares, C. J., Araújo, E., Novaes, R. M. O., Teodoro, V. V., Flores‐Mir, C., Kim, K. B., & Almeida, G. D. A. (2024) · Pediatric Pulmonology · doi:10.1002/ppul.27239 · Cited by 12 · see citing works
“However, several studies, 4,6,9,28 – 34 have emphasized that conclusions regarding the secondary effect of rapid palatal expansion (RPE) in cases with pediatric OSA should be considered with caution due to limitations such as inconsistent diagnostic criteria, poor inclusion and exclusion criteria,…”
Self-citationMandibular advancement device as treatment trial for catathrenia (nocturnal groaning)
Yu, M., Hao, Z., Xu, L., Wen, Y., Han, F., & Gao, X. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9290 · Cited by 11 · see citing works
“21 However,patientswith catathreniahadcraniofa-cial characteristics that were different from those in patients with OSA 22 ; therefore, the differences in the application of the MAD for catathrenia should be evaluated.”
Mandibular Advancement Appliances in Pediatric Obstructive Sleep Apnea: An Umbrella Review
Cozzi-Machado, C., Albertini, F. R., Silveira, S., & Machado-Júnior, A. J. (2023) · Sleep Science · doi:10.1055/s-0043-1776747 · Cited by 10 · see citing works
Zhao, T., Hua, F., & He, H. Y. (2021) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2021.101579 · Cited by 10 · see citing works
Elagib, T., Kyung, H., Hung, B. Q., & Hong, M. (2022) · The Korean Journal of Orthodontics · doi:10.4041/kjod21.267 · Cited by 10 · see citing works
Orthodontic treatment: Getting the timing right
Fleming, P. S., & Andrews, J. (2023) · Seminars in Orthodontics · doi:10.1053/j.sodo.2023.03.003 · Cited by 10 · see citing works
Mouth breathing and orthodontic intervention: Does the evidence support keeping our mouths shut?
Kandasamy, S. (2025) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2025.02.005 · Cited by 10 · see citing works
Making Sense of the Noise: Toward Rational Treatment for Obstructive Sleep Apnea
Kezirian, E. J., Simmons, M., Schwab, R. J., Cistulli, P. A., Li, K. K., Weaver, E. M., Goldberg, A. N., & Malhotra, A. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202005-1939pp · Cited by 10 · see citing works
Lin, L., Zhao, T., Ngan, P., Zhuang, Y., Qin, D., Hua, F., & He, H. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02852-x · Cited by 11 · see citing works
Rossi, C., Templier, L., Miguez, M., Cruz, J. D. L., Curto, A., Albaladejo, A., & Lagravère, M. O. (2020) · CRANIO® · doi:10.1080/08869634.2020.1823104 · Cited by 10 · see citing works
“This, together with the use of simple screening questions, questionnaires and/or techniques, means that dentists are ideally placed to perform OSA screening and to identify potential patients [6,21,22].”
BackgroundKim, S., Ahn, H., & Kim, S.-W. (2020) · CRANIO® · doi:10.1080/08869634.2020.1839722 · Cited by 10 · see citing works
Alharbi, L. N., Alsaikhan, M. A., Ali, S. N. A., & Farah, R. I. (2021) · Children · doi:10.3390/children8090768 · Cited by 10 · see citing works
Karadeniz, C., Lee, K. W. C., Lindsay, D., Karadeniz, E. İ., & Flores‐Mir, C. (2021) · The Angle Orthodontist · doi:10.2319/041921-316.1 · Cited by 10 · see citing works
Self-citationThe role of orthodontists in the multidisciplinary management of obstructive sleep apnea
Faber, J., Mota, A., Ho, L.-I., & Darendeliler, M. A. (2024) · Progress in Orthodontics · doi:10.1186/s40510-024-00541-3 · Cited by 9 · see citing works
“Treatment with MAA begins with obtaining a bite registration with the mandible advanced, typically set at about 50–75% of the maximum advancement potential [32, 33].”
BackgroundIntra-individual variation of upper airway measurements based on computed tomography
Zhou, N., Ho, J. T. F., Klop, C., Schreurs, R., Beenen, L. F. M., Aarab, G., & de Lange, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259739 · Cited by 9 · see citing works
“As recommended by the American Association of Orthodontists White Paper [36], three-dimensional imaging of the airway is a snapshot of a specific moment of the breathing cycle and such technique currently does not represent a proper and reliable risk assessment tool for OSA.”
BackgroundTemplier, L., Rossi, C., Lagravère, M. O., Pujol, R. F., Muwanguzi, M., & Gianoni‐Capenakas, S. (2023) · European Journal of Orthodontics · doi:10.1093/ejo/cjad060 · Cited by 8 · see citing works
Li, Y., Zhao, T., Ngan, P., Yi, S., Wei, Z., Hua, F., & He, H. (2024) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.12873 · Cited by 8 · see citing works
“If untreated, it can adversely affect growth, cognitive function and cardiovascular health in children [6].”
Giudice, A. L., Polizzi, A., Lagravère, M. O., Flores‐Mir, C., Isola, G., Ronsivalle, V., & Leonardi, R. M. (2024) · European Journal of Orthodontics · doi:10.1093/ejo/cjae077 · Cited by 8 · see citing works
Self-citationOh, H., Arab, M., Kim, E., Vaughan, M. A., Park, J., & Yoon, A. J.-S. (2025) · Seminars in Orthodontics · doi:10.1053/j.sodo.2025.03.005 · Cited by 8 · see citing works
Arab, M., Ansari, Y. S. E., Pelayo, R., & Yoon, A. J.-S. (2025) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.12930 · Cited by 8 · see citing works
Effect of functional appliances on the airway in Class II malocclusions
Padmanabhan, S. (2020) · Journal of the World Federation of Orthodontists · doi:10.1016/j.ejwf.2020.08.006 · Cited by 8 · see citing works
Feng, X., Chen, Y.-C., Cai, W., Lie, S. A., Hellén‐Halme, K., & Shi, X. (2021) · BMC Medical Imaging · doi:10.1186/s12880-021-00659-4 · Cited by 8 · see citing works
Treatment of a high angle protrusion case optimized with interdisciplinary approaches and TSADs
Liaw, J. J. L., Park, J. H., Shih, I. Y. H., Yang, S. Y. H., & Tsai, F. F. (2021) · AJO-DO Clinical Companion · doi:10.1016/j.xaor.2021.08.001 · Cited by 8 · see citing works
Teixeira, R. E., Massaro, C. D. S., & Garib, D. G. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05213-w · Cited by 8 · see citing works
Association between the Obstructive Sleep Apnea and Cephalometric Parameters in Teenagers
Manrikyan, G., Vardanyan, I., Markaryan, M. M., Manrikyan, M., Badeyan, E. H., Manukyan, A. H., Gevorgyan, M. A., & Khachatryan, S. G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216851 · Cited by 8 · see citing works
“For pediatric patients, treatment may include non-surgical maxillary expansion and orthodontic functional appliances [24,25].”
BackgroundDesai, R., Komperda, J., Elnagar, M. H., Viana, G., & Galang‐Boquiren, M. T. (2023) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.12728 · Cited by 8 · see citing works
“12 The relationship between minimal cross-sectional area (min CSA) or total volume and OSA remains unclear, and there is a lack of robust CFD studies comparing non-OSA and OSA subjects.”
Sheats, R. D., Massé, J.-F., Levine, M., Aarab, G., Cruz, M. G. M. E., Simmons, M., Stauffer, J., Carstensen, S., Chiang, H. K., Galang‐Boquiren, M. T., et al. (2024) · Journal of Dental Sleep Medicine · doi:10.15331/jdsm.7332 · Cited by 8 · see citing works
Self-citationDentists’ role in obstructive sleep apnea: A more comprehensive review
Alrejaye, N. S., & Al-Jahdali, H. H. (2024) · Sleep Epidemiology · doi:10.1016/j.sleepe.2024.100073 · Cited by 8 · see citing works
Duan, J., Xia, W., Li, X., Zhang, F., Wang, F., Chen, M., Chen, Q., Wang, B., & Li, B. (2025) · BMC Oral Health · doi:10.1186/s12903-025-05528-y · Cited by 8 · see citing works
“The main outcome index, AHI, validated the conclusion of the American Society of Orthodontists’ White Paper [26] that MAA can reduce AHI.”
Díaz, M. F. D., Arrieta, X. S., Caballero‐García, S., & Palti, D. G. (2023) · CRANIO® · doi:10.1080/08869634.2023.2281286 · Cited by 7 · see citing works
“The most common symptoms of POSA include snoring, paradoxical breathing, excessive daytime sleepiness, hyperactivity/behavioral problems [2,4,6,7].”
The Relationship between Nocturnal Enuresis and Obstructive Sleep Apnea in Children
Andreu-Codina, M., Jovanovic, D. N., Esteller, E. C. I., Clusellas, N., Artés, M., Moyano, J., & Pérez, A. P. (2024) · Children · doi:10.3390/children11091148 · Cited by 7 · see citing works
“The prevalence of childhood OSA diagnosed by varying criteria was reported to be 1% to 4% [3].”
BackgroundInfluentialThree-dimensional pharyngeal airway space changes after bimaxillary advancement
Rocha, T. L., Lima, L. M., Pinzan, A., Sant’Ana, E., Nogueira, R. L. M., Bronfman, C. N., & Janson, G. (2021) · Dental Press Journal of Orthodontics · doi:10.1590/2177-6709.26.5.e2119364.oar · Cited by 9 · see citing works
Niu, X., Yung, A. K. C., Strickertsson, T. I. B., Stoustrup, P. B., Cornelis, M. A., & Cattaneo, P. M. (2022) · Acta Odontologica Scandinavica · doi:10.1080/00016357.2021.2023755 · Cited by 7 · see citing works
“The recommendation for SDB screening has also been supported in the white paper published by the American Association of Orthodontists in 2019, aiming at offering guidance to the orthodontist about his/her role in the clinical risk assessment for management of obstructive SDB, where the PSQ/SRDB was recommended as a p…”
BackgroundMethodInfluentialMarya, A., Inglam, S., Chantarapanich, N., Wanchat, S., Rithvitou, H., & Naronglerdrit, P. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04779-5 · Cited by 7 · see citing works
“In 2019, the Board of Trustees of the American Association of Ortho-dontists (AAO) published a white paper utilizing inputs from experts in dental sleep medicine [27].”
BackgroundParadowska-Stolarz, A. M. (2025) · Dental and Medical Problems · doi:10.17219/dmp/194232 · Cited by 7 · see citing works
de Oliveira, I. C. V., Santos, R. T. P., Freitas, B. V., Reher, P., & Rodrigues, V. P. (2022) · Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie · doi:10.1007/s00056-022-00403-9 · Cited by 7 · see citing works
Guo, R., Wang, S., Zhang, L., Li, L., Yu, Q., Huang, Y., & Li, W. (2022) · Head & Face Medicine · doi:10.1186/s13005-022-00334-1 · Cited by 7 · see citing works
“It is also important to note that there is no direct link between a narrow airway and OSA.”
BackgroundInfluentialDental Sleep Medicine Education Amongst Accredited Orthodontic Programmes in Thailand
Peanchitlertkajorn, S., Chalidapongse, P., Jiansuwannapas, T., Surinsirirat, N., Khamphuang, P., Boonyai, P., & Sipiyaruk, K. (2023) · International Dental Journal · doi:10.1016/j.identj.2023.10.020 · Cited by 7 · see citing works
Thomas, D. C., Somaiya, T. S., Cruz, M. G. M. E., Pitchumani, P. K., Ardeshna, A. P., Ravi, A., & Prabhakar, S. (2024) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2024.05.007 · Cited by 6 · see citing works
Fagundes, N. C. F., Bastos, R. T. D. R. M., Perez, A. J., Flores‐Mir, C., & Normando, D. (2024) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.12866 · Cited by 6 · see citing works
Self-citationSleep‐disordered breathing in children seeking orthodontic care—an Australian perspective
Wellham, A., Kim, C., Kwok, S., Lee, R., Naoum, S. J., Razza, J. M., & Goonewardene, M. (2022) · Australian Dental Journal · doi:10.1111/adj.12945 · Cited by 6 · see citing works
Honglertnapakul, Y., Peanchitlertkajorn, S., Likitkulthanaporn, A., Saengfai, N. N., Chaweewannakorn, C., & Boonpratham, S. (2024) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.12798 · Cited by 6 · see citing works
3D analysis of upper airway morphology related to obstructive sleep apnea severity
Jessadapornchai, T., Samruajbenjakun, B., Chanmanee, P., & Chalidapongse, P. (2024) · Journal of the World Federation of Orthodontists · doi:10.1016/j.ejwf.2024.03.003 · Cited by 6 · see citing works
Papageorgiou, S. N., Zyli, M., & Papadopoulou, A. K. (2025) · European Journal of Orthodontics · doi:10.1093/ejo/cjaf012 · Cited by 10 · see citing works
Bignotti, D., STEFANI, A. D., Mezzofranco, L., Bruno, G., & Gracco, A. L. T. (2019) · Sleep Medicine Research · doi:10.17241/smr.2019.00465 · Cited by 7 · see citing works
“In fact the long-term results of these therapies are not yet certain and therefore it is important that the therapeutic objective is twofold: orthodontic and directed to solve the OSAS in the period of development [12].”
BackgroundAlSaty, G., Xiang, J. Y., Burns, M., Eliliwi, M., Palomo, J. M., Martin, C. A., Weaver, B. D., & Ngan, P. (2020) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2019.09.016 · Cited by 9 · see citing works
Self-citationSelf‐reported oral moistening disorders in obstructive sleep apnoea: A scoping review
Raoof, M., Verhoeff, M. C., Kooshki, R., Aarab, G., & Lobbezoo, F. (2023) · Journal of Oral Rehabilitation · doi:10.1111/joor.13532 · Cited by 6 · see citing works
- Authors
- Behrents, R. G., Shelgikar, A. V., Conley, R. S., Flores-Mir, C., Hans, M., Levine, M., McNamara, J. A., Palomo, J. M., Pliska, B., Stockstill, J. W., Wise, J., Murphy, S., Nagel, N. J., & Hittner, J.
- Affiliations
- Saint Louis University (US)
- University of Michigan (US)
- University at Buffalo, State University of New York (US)
- Case Western Reserve University (US)
- University of Tennessee Health Science Center (US)
- University of British Columbia (CA)
- Fresno City College (US)
- American Association of Orthodontists (US)
- Corresponding author
- Behrents, Rolf G.
- ORCID
- Venue
- American Journal of Orthodontics and Dentofacial Orthopedics
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 156
- Issue
- 1
- Pages
- 13-28.e1
- ISSN
- 0889-5406 (ISSN-L)
- OpenAlex
- W2954751744
- Cited by
- 284
- References
- 54
- Citations by year
- 2026: 39 · 2025: 37 · 2024: 50 · 2023: 44 · 2022: 51 · 2021: 45 · 2020: 15 · 2019: 3
- FWCI
- 19.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Orthodontics and Dentofacial Orthopedics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Keywords
- obstructive sleep apnea, orthodontics, dental sleep medicine, sleep medicine, clinical guidelines
- MeSH terms
- Academies and Institutes, Orthodontists, Humans, Orthodontic Appliances, Orthodontics, Physicians, Radiography, Dental, Risk Factors, Severity of Illness Index, United States, Prevalence, Treatment Outcome, Polysomnography, Sleep Apnea, Obstructive, Surgeons
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