Surgical risk reduction: Prophylactic salpingo-oophorectomy and prophylactic mastectomy
Abstract
Investigators have used retrospective and prospective study designs to provide much needed data on the extent of risk reduction after prophylactic oophorectomy and mastectomy in women at increased risk for breast and ovarian cancer. In this publication we identify those women who may wish to consider prophylactic surgery, review data demonstrating the efficacy of prophylactic surgery, and discuss potential surgical complications. We also present data about the frequency of use and psychosocial impact of prophylactic surgery in this typically young group of women. Finally, we provide general treatment guidelines for the practicing clinician.
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The majority of women following prophylactic mastectomy reported decreased hereditary cancer-related distress, while other psychosocial functioning does not appear to be significantly negatively affected.
“Studies have shown that the majority of women following PM reported decreased (hereditary) cancer related distress while other psychosocial functioning does not appear to be significantly affected in a negative way [5,8-10].”
From Standard psychological consultations and follow up for women at increased risk of hereditary breast cancer considering prophylactic mastectomy (2009) · cites this paper as [5]
Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
Jemal, A., Tiwari, R. C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., Feuer, E. J., & Thun, M. J. (2004) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.54.1.8 · Cited by 3,984 · see citing works
Gail, M. H., Brinton, L. A., Byar, D. P., Corle, D. K., Green, S. B., Schairer, C., & Mulvihill, J. J. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.24.1879 · Cited by 3,334 · see citing works
Breast and Ovarian Cancer Risks Due to Inherited Mutations in <i>BRCA1</i> and <i>BRCA2</i>
King, M.-C., Marks, J. H., & Mandell, J. B. (2003) · Science · doi:10.1126/science.1088759 · Cited by 2,229 · see citing works
Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations
Rebbeck, T. R., Lynch, H. T., Neuhausen, S. L., Narod, S. A., Veer, L. V., Garber, J. E., Evans, D. G., Isaacs, C. J., Daly, M. B., Matloff, E. T., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012158 · Cited by 1,462 · see citing works
Efficacy of Bilateral Prophylactic Mastectomy in Women with a Family History of Breast Cancer
Hartmann, L. C., Schaid, D. J., Woods, J. E., Crotty, T. P., Myers, J. L., Arnold, P. G., Petty, P. M., Sellers, T. A., Johnson, J. L., McDonnell, S. K., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400201 · Cited by 1,428 · see citing works
Self-citationRisk-Reducing Salpingo-oophorectomy in Women with aBRCA1orBRCA2Mutation
Kauff, N. D., Satagopan, J. M., Robson, M. E., Scheuer, L., Hensley, M. L., Hudis, C. A., Ellis, N. A., Boyd, J. A., Borgen, P. I., Barakat, R. R., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020119 · Cited by 1,250 · see citing works
Menopause and the Risk of Coronary Heart Disease in Women
Colditz, G. A., Willett, W. C., Stampfer, M. J., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704303161801 · Cited by 1,153 · see citing works
Postmenopausal Hormone Replacement Therapy: Scientific Review
Nelson, H. D., Humphrey, L. L., Nygren, P., Teutsch, S. M., & Allan, J. D. (2002) · JAMA · doi:10.1001/jama.288.7.872 · Cited by 990 · see citing works
Meijers-Heijboer, H., van Geel, B., van Putten, W. L. J., Henzen-Logmans, S. C., Seynaeve, C., Menke-Pluymers, M. B. E., Bartels, C. C. M., Verhoog, L. C., van den Ouweland, A. M. W., Niermeijer, M. F., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107193450301 · Cited by 973 · see citing works
Overview of the main outcomes in breast-cancer prevention trials
Cuzick, J. M., Powles, T. J., Veronesi, U., Forbes, J., Edwards, R. P., Ashley, S., & Boyle, P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12342-2 · Cited by 963 · see citing works
Lakhani, S., van de Vijver, M., Jacquemier, J., Anderson, T., Osin, P., McGuffog, L., & Easton, D. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.09.023 · Cited by 888 · see citing works
Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program.
Brose, M., Rebbeck, T., Calzone, K., Stopfer, J., Nathanson, K., & Weber, B. (2002) · Journal of the National Cancer Institute · doi:10.1093/jnci/94.18.1365 · Cited by 772 · see citing works
Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers
Hartmann, L. C., Sellers, T. A., Schaid, D. J., Frank, T. S., Soderberg, C. L., Sitta, D. L., Frost, M. H., Grant, C. S., Donohue, J. H., Woods, J. E., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.21.1633 · Cited by 743 · see citing works
Self-citationBreast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers
Rebbeck, T. R., Levin, A. M., Eisen, A. F., Snyder, C., Watson, P. A., Cannon‐Albright, L., Isaacs, C. J., Olopade, O., Garber, J. E., Godwin, A. K., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.17.1475 · Cited by 670 · see citing works
Oral Contraceptives and the Risk of Hereditary Ovarian Cancer
Narod, S. A., Risch, H. A., Moslehi, R., Dørum, A., Neuhausen, S. L., Olsson, H. L., Provencher, D. M., Radice, P., Evans, D. G., Bishop, S. E., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808133390702 · Cited by 612 · see citing works
Clinicopathologic features of BRCA-linked and sporadic ovarian cancer.
Boyd, J., Sonoda, Y., Federici, M. G., Bogomolniy, F., Rhei, E., Maresco, D., Saigo, P., Almadrones, L., Barakat, R., Brown, C., et al. (2000) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.283.17.2260 · Cited by 570 · see citing works
Warner, E., Plewes, D. B., Shumak, R. S., Catzavelos, G. C., Prospero, L. S. D., Yaffe, M. J., Goel, V., Ramsay, E. A., Chart, P., Cole, D. E. C., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.15.3524 · Cited by 461 · see citing works
Complications Leading to Surgery after Breast Implantation
Gabriel, S. E., Woods, J. E., O’Fallon, W. M., Beard, C. M., Kurland, L. T., & Melton, L. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703063361001 · Cited by 446 · see citing works
Shapiro, C. L., Manola, J. B., & LeBoff, M. S. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.14.3306 · Cited by 440 · see citing works
RECURRENT DISLOCATION OF THE SHOULDER
British Medical Journal Publishing Group (1929) · BMJ · doi:10.1136/bmj.2.3589.732 · Cited by 440 · see citing works
Outcome of Preventive Surgery and Screening for Breast and Ovarian Cancer in BRCA Mutation Carriers
Scheuer, L. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.5.1260 · Cited by 404 · see citing works
Hormonal Treatment of Postmenopausal Women
Wood, A. J. J., & Belchetz, P. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301508 · Cited by 386 · see citing works
INTRA-ABDOMINAL CARCINOMATOSIS AFTER PROPHYLACTIC OOPHORECTOMY IN OVARIAN-CANCER-PRONE FAMILIES
Tobacman, J., Tucker, M., Kase, R. G., Greene, M., Costa, J. C., & Fraumeni, J. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92681-2 · Cited by 351 · see citing works
BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer.
Moslehi, R., Chu, W., Karlan, B., Fishman, D., Risch, H., Fields, A., Smotkin, D., ben-David, Y., Rosenblatt, J., Russo, D., et al. (2000) · American Journal of Human Genetics · doi:10.1086/302853 · Cited by 341 · see citing works
Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation.
Meijers-Heijboer, E. J., Verhoog, L., Brekelmans, C., Seynaeve, C., Tilanus-Linthorst, M., Wagner, A., Dukel, L., Devilee, P., van den Ouweland, A. V. D., van Geel, A. V., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02347-3 · Cited by 328 · see citing works
Occult Carcinoma in Prophylactic Oophorectomy Specimens
Colgan, T. J., Murphy, J., Cole, D. E. C., Narod, S. A., & Rosen, B. P. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200110000-00009 · Cited by 327 · see citing works
Frost, M. H. (2000) · JAMA · doi:10.1001/jama.284.3.319 · Cited by 325 · see citing works
Brekelmans, C. T. M., Seynaeve, C., Bartels, C. C. M., Tilanus‐Linthorst, M. M. A., Meijers-Heijboer, E. J., Crépin, C., van Geel, A. N., Menke, M., Verhoog, L. C., van den Ouweland, A., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.4.924 · Cited by 306 · see citing works
Pathologic findings in prophylactic oophorectomy specimens in high-risk women.
Leeper, K., Garcia, R., Swisher, E., Goff, B., Greer, B., & Paley, P. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6779 · Cited by 295 · see citing works
Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth
Brugère, J., Guénel, P., Leclerc, A., & Rodriguez, J. (1986) · Cancer · doi:10.1002/1097-0142(19860115)57:2 · Cited by 289 · see citing works
Saarto, T., BLOMQVIST, C. P., Välimäki, M., Mäkelä, P. M., Sarna, S. J., & Elomaa, I. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.4.1341 · Cited by 265 · see citing works
Prophylactic surgery decisions and surveillance practices one year following BRCA1/2 testing.
Lerman, C., Hughes, C., Croyle, R. T., Main, D., Durham, C., Snyder, C. L., Bonney, A., Lynch, J., Narod, S., & Lynch, H. (2000) · Preventive Medicine · doi:10.1006/pmed.2000.0684 · Cited by 262 · see citing works
A Genetic Epidemiological Study of Carcinoma of the Fallopian Tube
Aziz, S., Kuperstein, G., Rosen, B. P., Cole, D. E. C., Nedelcu, R., McLaughlin, J. R., & Narod, S. A. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2000.6095 · Cited by 221 · see citing works
Chlebowski, R. T., Col, N. F., Winer, E. P., Collyar, D. E., Cummings, S. R., Vogel, V. G., Burstein, H. J., Eisen, A. F., Lipkus, I. M., & Pfister, D. G. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.06.029 · Cited by 197 · see citing works
Paley, P., Swisher, E. M., Garcia, R., Agoff, S., Greer, B. E., Peters, K., & Goff, B. A. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2000.6071 · Cited by 193 · see citing works
Occult ovarian tumors in women with BRCA1 or BRCA2 mutations undergoing prophylactic oophorectomy.
Lu, K. H., Garber, J. E., Cramer, D. W., Welch, W. R., Niloff, J., Schrag, D., Berkowitz, R., & Muto, M. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.14.2728 · Cited by 188 · see citing works
Bacteria-associated hemophagocytic syndrome
Risdall, R. J., Brunning, R. D., Hernandez, J. I., & Gordon, D. (1984) · Cancer · doi:10.1002/1097-0142(19841215)54:12 · Cited by 186 · see citing works
Prophylactic oophorectomy in inherited breast/ovarian cancer families.
Struewing, J. P., Watson, P., Easton, D., Ponder, B. A. J., Lynch, H. T., & Tucker, M. A. (1995) · PubMed · Cited by 184 · see citing works
Hatcher, M. B. (2001) · BMJ · doi:10.1136/bmj.322.7278.76 · Cited by 160 · see citing works
Prophylactic surgery in women with a hereditary predisposition to breast and ovarian cancer.
Eisen, A., Rebbeck, T., Wood, W., & Weber, B. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.9.1980 · Cited by 148 · see citing works
Bone Loss in Young Women With Karyotypically Normal Spontaneous Premature Ovarian Failure
Anasti, J. N. (1998) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00583-8 · Cited by 147 · see citing works
Osteoporosis after Oophorectomy for Non-malignant Disease in Premenopausal Women
Aitken, J. M., Hart, D. M., Anderson, J., Lindsay, R., Smith, D. A., & Speirs, C. F. (1973) · BMJ · doi:10.1136/bmj.2.5862.325 · Cited by 142 · see citing works
Long‐term effects of oral contraceptives on ovarian cancer risk
Bosetti, C., Negri, E., Trichopoulos, D., Franceschi, S., Beral, V., Τζώνου, Α., Parazzini, F., Greggi, S., & Vecchia, C. L. (2002) · International Journal of Cancer · doi:10.1002/ijc.10696 · Cited by 119 · see citing works
The woman at increased risk for breast cancer: evaluation and management strategies
Bilimoria, M. M., & Morrow, M. (1995) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.45.5.263 · Cited by 111 · see citing works
Failure of subcutaneous mastectomy to prevent the development of breast cancer
Goodnight, J. E., Quagliana, J. M., & Morton, D. L. (1984) · Journal of Surgical Oncology · doi:10.1002/jso.2930260313 · Cited by 107 · see citing works
Ovarian cancer in women with prior hysterectomy: a 14-year experience at the University of Miami.
Sightler, S. E., Boike, G. M., Estape, R. E., & Averette, H. E. (1991) · PubMed · Cited by 104 · see citing works
Primary Breast Cancer After Prophylactic Mastectomy
Ziegler, L. D., & Kroll, S. S. (1991) · American Journal of Clinical Oncology · doi:10.1097/00000421-199110000-00018 · Cited by 103 · see citing works
Tiller, K., Meiser, B., Butow, P., Clifton, M., Thewes, B., Friedlander, M., & Tucker, K. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6737 · Cited by 88 · see citing works
Cancer of the breast after prophylactic subcutaneous mastectomy
Eldar, S., Meguid, M. M., & Beatty, J. D. (1984) · The American Journal of Surgery · doi:10.1016/0002-9610(84)90352-0 · Cited by 84 · see citing works
Reoperations after prophylactic mastectomy with or without implant reconstruction
Zion, S. M., Slezak, J. M., Sellers, T. A., Woods, J. E., Arnold, P. G., Petty, P. M., Donohue, J. H., Frost, M. H., Schaid, D. J., & Hartmann, L. C. (2003) · Cancer · doi:10.1002/cncr.11757 · Cited by 79 · see citing works
Self-citationFry, A. M., Busby‐Earle, C., Rush, R., & Cull, A. (2001) · Psycho-Oncology · doi:10.1002/pon.512 · Cited by 76 · see citing works
Averette, H. E., Hoskins, W. J., Nguyen, H. N., Boike, G. M., Flessa, H. C., Chmiel, J. S., Zuber, K., Karnell, L. H., & Winchester, D. P. (1993) · PubMed · Cited by 72 · see citing works
Risk-Reduction Mastectomy: Clinical Issues and Research Needs
Stefanek, M. E., Hartmann, L. C., & Nelson, W. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.17.1297 · Cited by 66 · see citing works
Self-citationOvarian cancer and high-risk women—implications for prevention, screening, and early detection
Modugno, F. (2003) · Gynecologic Oncology · doi:10.1016/s0090-8258(03)00254-3 · Cited by 63 · see citing works
Hysterectomy, oophorectomy, and heart disease risk factors in older women.
Kritz‐Silverstein, D. C., Barrett-Connor, E. L., & WINGARD, D. L. (1997) · American Journal of Public Health · doi:10.2105/ajph.87.4.676 · Cited by 61 · see citing works
Hicken, N. F. (1940) · Archives of Surgery · doi:10.1001/archsurg.1940.04080010009002 · Cited by 61 · see citing works
Miller, S. M., Fang, C. Y., Manne, S. L., Engstrom, P. F., & Daly, M. B. (1999) · Gynecologic Oncology · doi:10.1006/gyno.1999.5611 · Cited by 60 · see citing works
Lipoprotein(a) and other lipids after oophorectomy and estrogen replacement therapy
Bruschi, F., Meschìa, M., Soma, M. R., PEROTTI, D., Paoletti, R., & GIORGIOCROSIGNANI, P. (1996) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(96)00349-3 · Cited by 58 · see citing works
Pharmacokinetics of oral 17 beta-estradiol.
Ra, L., & Cassidenti, D. L. (1992) · PubMed · Cited by 56 · see citing works
Uptake of screening and prevention in women at very high risk of breast cancer
Evans, D. G., Lalloo, F. I., Shenton, A., Boggis, C. R. M., & Howell, A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06039-1 · Cited by 54 · see citing works
Fry, A., Rush, R., Busby-Earle, C., & Cull, A. (2001) · Preventive Medicine · doi:10.1006/pmed.2001.0924 · Cited by 48 · see citing works
Subcutaneous Mastectomy: Current State of the Art
Woods, J. E. (1983) · Annals of Plastic Surgery · doi:10.1097/00000637-198312000-00016 · Cited by 39 · see citing works
Prophylactic oophorectomy and ovarian cancer surveillance. Patient perceptions and satisfaction.
Swisher, E. M., Babb, S., Whelan, A., Mutch, D. G., & Rader, J. S. (2001) · PubMed · Cited by 34 · see citing works
Saarto, T., BLOMQVIST, C. P., Ehnholm, C., Taskinen, M., & Elomaa, I. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954058 · Cited by 33 · see citing works
Jh, W., Cf, J., Swanson, J. S., Ma, P., Aa, O., Sh, M., & Ws, F. (1986) · PubMed · Cited by 32 · see citing works
Newman, L. A., Kuerer, H., Hunt, K. K., Vlastos, G., Ames, F., Ross, M. I., & Singletary, S. (2000) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(00)00361-6 · Cited by 29 · see citing works
Screening for breast cancer with MRI
Morris, E. A. (2003) · Seminars in Ultrasound CT and MRI · doi:10.1016/s0887-2171(03)90025-4 · Cited by 27 · see citing works
Merz, C. N. B., Olson, M. B., Johnson, B. D., Bittner, V., Hodgson, T. K., Berga, S. L., Braunstein, G. D., Pepine, C. J., Reís, S. E., Sopko, G. S., et al. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01366-9 · Cited by 25 · see citing works
Influence of bilateral oophorectomy upon lipid metabolism
Suda, Y., Ohta, H., Makita, K., Takamatsu, K., Horiguchi, F., & Nozawa, S. (1998) · Maturitas · doi:10.1016/s0378-5122(97)00089-3 · Cited by 23 · see citing works
Kern, W., Behre, G., Rudolf, T., Kerkhoff, A., Grote‐Metke, A., Eimermacher, H., Kubica, U., Wormann, B. J., Büchner, T., & Hiddemann, W. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980715)83:2 · Cited by 19 · see citing works
Schapira, D. V., Kumar, N. B., & Lyman, G. H. (1993) · Cancer · doi:10.1002/1097-0142(19930501)71:9 · Cited by 11 · see citing works
Prophylactic mastectomy; evolving perspectives
Sakorafas, G. H., & Tsiotou, A. G. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00343-3 · Cited by 8 · see citing works
Flagged first, then by citations
4 of the 78 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Current Management Strategies for Ovarian Cancer
Aletti, G. D., Gallenberg, M. M., Cliby, W. A., Jatoi, A., & Hartmann, L. C. (2007) · Mayo Clinic Proceedings · doi:10.4065/82.6.751 · Cited by 196 · see citing works
Self-citationPractice Bulletin No 182: Hereditary Breast and Ovarian Cancer Syndrome
(2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002296 · Cited by 193 · see citing works
Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations
Eleje, G. U., Eke, A. C., Ezebialu, I. U., Ikechebelu, J. I., Ugwu, E. O., & Okonkwo, O. O. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012464.pub2 · Cited by 172 · see citing works
Pruthi, S., Gostout, B. S., & Lindor, N. M. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0414 · Cited by 152 · see citing works
Harmsen, M. G., Jong, M. A.-D., Hoogerbrugge, N., Maas, A. H. E. M., Prins, J. B., Bulten, J., Teerenstra, S., Adang, E., Piek, J. M. J., van Doorn, H. C., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1597-y · Cited by 107 · see citing works
Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery
Budiana, I. N. G., Angelina, M., & Pemayun, T. G. A. (2019) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.galenos.2018.2018.0119 · Cited by 77 · see citing works
Madalinska, J. B., van Beurden, M., Bleiker, E. M. A., Valdimarsdottir, H. B., Lubsen-Brandsma, L. A. C., Massuger, L. F. A. G., Mourits, M. J. E., Gaarenstroom, K. N., van Dorst, E. B. L., van der Putten, H. W. H. M., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.4922 · Cited by 77 · see citing works
Looking different, feeling different: women’s reactions to risk-reducing breast and ovarian surgery
kConFab Psychosocial Group on behalf of the kConFab Investigators, Hallowell, N., Baylock, B., Heiniger, L., Butow, P. N., Patel, D., Meiser, B., Saunders, C., & Price, M. A. (2012) · Familial Cancer · doi:10.1007/s10689-011-9504-4 · Cited by 66 · see citing works
Epidemiological and Genetic Factors Associated With Ovarian Cancer
McLemore, M. R., Miaskowski, C. A., Aouizerat, B. E., Chen, L.-M., & Dodd, M. J. (2009) · Cancer Nursing · doi:10.1097/ncc.0b013e31819d30d6 · Cited by 66 · see citing works
Bresser, P. J. C., Seynaeve, C., Gool, A. R. V., Niermeijer, M. F., Duivenvoorden, H. J., van Dooren, S., van Geel, A. N., Menke‐Pluijmers, M. B. E., Klijn, J. G. M., & Tibben, A. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.09.009 · Cited by 63 · see citing works
The Role of Prophylactic Surgery in Cancer Prevention
You, Y. N., Lakhani, V. T., & Wells, S. A. (2007) · World Journal of Surgery · doi:10.1007/s00268-006-0616-1 · Cited by 54 · see citing works
Gahm, J., Jurell, G., Edsander-Nord, Å., & Wickman, M. (2008) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2008.11.014 · Cited by 52 · see citing works
Kenen, R. H., Shapiro, P. J., Friedman, S., & Coyne, J. C. (2007) · Psycho-Oncology · doi:10.1002/pon.1152 · Cited by 49 · see citing works
Risk-Reducing Strategies for Ovarian Cancer in BRCA Mutation Carriers: A Balancing Act
Tschernichovsky, R., & Goodman, A. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0444 · Cited by 49 · see citing works
Hereditary Breast and Ovarian Cancer Syndrome
Inuzuka, M., & Nakamura, S. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.02.017 · Cited by 48 · see citing works
Cost-Effectiveness of Testing for Breast Cancer Susceptibility Genes
Holland, M. L., Huston, A. J., & Noyes, K. (2008) · Value in Health · doi:10.1111/j.1524-4733.2008.00418.x · Cited by 41 · see citing works
van Driel, C., de Bock, G., Schroevers, M., & Mourits, M. (2019) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15471 · Cited by 33 · see citing works
Vodermaier, A., Esplen, M. J., & Maheu, C. (2010) · Familial Cancer · doi:10.1007/s10689-010-9325-x · Cited by 32 · see citing works
How medical choices influence quality of life of women carrying a BRCA mutation
Harmsen, M. G., Hermens, R., Prins, J. B., Hoogerbrugge, N., & de Hullu, J. A. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.07.010 · Cited by 28 · see citing works
Tan, M. B., Bleiker, E. M., Menke-Pluymers, M. B., Van Gool, A. R., van Dooren, S., Van Geel, B. N., Tilanus-Linthorst, M. M., Bartels, K. C., Klijn, J. G., Brekelmans, C. T., et al. (2009) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-7-6 · Cited by 27 · see citing works
“Since the decision to pursue PM is complex, personal, and ultimately irreversible, it has been suggested that decisionmaking should include counseling of the woman by a multidisciplinary team of specialists, addressing the benefits of the different procedures as well as the surgical and psychological risks of PM [5].”
BackgroundFIGO position statement on opportunistic salpingectomy as an ovarian cancer prevention strategy
Mor‐Hadar, D., Wilailak, S., Berek, J. S., & McNally, O. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15884 · Cited by 27 · see citing works
Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery
Ma, I. T., Gray, R. J., Wasif, N., Butler, K. A., Cornella, J. L., Magrina, J. F., Magtibay, P. M., Casey, W. J., Mahabir, R. C., Rebecca, A. M., et al. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-016-5479-6 · Cited by 25 · see citing works
McCann, G. A.-L., & Eisenhauer, E. L. (2014) · Journal of Surgical Oncology · doi:10.1002/jso.23743 · Cited by 24 · see citing works
van Driel, C. M. G., de Bock, G. H., Arts, H. J. G., Sie, A. S., Hollema, H., Oosterwijk, J. C., & Mourits, M. J. E. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.12.009 · Cited by 21 · see citing works
Kim, D.-W., Kang, E., Hwang, E., Ma, S. Y., Hwang, Y., Yom, C. K., Kim, K., No, J. H., Kim, Y. B., & Kim, S. W. (2013) · Familial Cancer · doi:10.1007/s10689-013-9625-z · Cited by 20 · see citing works
Who is prone to high levels of distress after prophylactic mastectomy and/or salpingo-ovariectomy?
Bresser, P. J. C., Van Gool, A. R., Seynaeve, C., Duivenvoorden, H. J., Niermeijer, M. F., van Geel, A. N., Menke, M., Klijn, J. G. M., & Tibben, A. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm274 · Cited by 18 · see citing works
AlHilli, M. M., & Al-Hilli, Z. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2018.09.767 · Cited by 15 · see citing works
Ovarian Cancer Genetics and Implications for Imaging and Therapy
Elsherif, S. B., Faria, S. C., Lall, C. G., Iyer, R. B., & Bhosale, P. (2019) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0000000000000932 · Cited by 15 · see citing works
Epidemiology and Etiology of Ovarian Cancer
Montes, A., Gómez, J., Viejo, M. N., Bermejo, M., Urrutia, S., & Mata, J. G. (2012) · InTech eBooks · doi:10.5772/27679 · Cited by 23 · see citing works
Gynaecological oncology perspective on management of the menopause
REES, M. C. P. (2006) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2006.03.042 · Cited by 13 · see citing works
Risk‐reducing surgery for women at high risk of epithelial ovarian cancer
Gaughan, E. M. G., & Walsh, T. (2014) · The Obstetrician & Gynaecologist · doi:10.1111/tog.12107 · Cited by 12 · see citing works
Strategies for Ovarian Cancer Prevention
Dann, R. B., Kelley, J. L., & Zorn, K. K. (2007) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2007.10.001 · Cited by 9 · see citing works
Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery
Budiana, I. N. G., Angelina, M., & Pemayun, T. G. A. (2018) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.2018.0119 · Cited by 9 · see citing works
Khadim, M. F., Eastwood, M. P., Price, J. H., Morrison, P. J., & Khan, K. J. (2013) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2013.09.018 · Cited by 9 · see citing works
Jong, M. A.-D., DeJong, C. A. J., Hermens, R., Kissane, D. W., Massuger, L. F. A. G., Hoogerbrugge, N., Prins, J. B., & deHullu, J. A. (2017) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2017.1296429 · Cited by 8 · see citing works
Scar-Free Laparoscopy in BRCA-Mutated Women
Restaino, S., Finelli, A., Pellecchia, G., Biasioli, A., Mauro, J., Ronsini, C., Martina, M. D., Arcieri, M., Corte, L. D., Sorrentino, F., et al. (2022) · Medicina · doi:10.3390/medicina58070943 · Cited by 6 · see citing works
D’Abbondanza, J. A., George, R., Kives, S. L., & Musgrave, M. A. (2020) · Plastic Surgery · doi:10.1177/2292550320928551 · Cited by 5 · see citing works
Trivedi, M. S., Arber, N., Friedman, E., Garber, J. E., Holcomb, K., Horowitz, N. S., Wright, J. D., Lee, J. J., Vornik, L. A., Abutaseh, S., et al. (2022) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-22-0051 · Cited by 4 · see citing works
Psychological factors that influence decision making about prophylactic surgery
Fang, C. Y., Mckenzie, T., Miller, S. M., & Daly, M. B. (2005) · Complutensian Scientific Journals (Complutense University of Madrid) · doi:10.5209/rev_psic.2005.v2.n2.16890 · Cited by 4 · see citing works
Clinical Approach to Diagnosis and Management of Ovarian, Fallopian Tube, and Peritoneal Carcinoma
Silver, D. F., Dennis, S., & Zgheib, N. B. (2011) · Surgical pathology clinics · doi:10.1016/j.path.2010.12.003 · Cited by 3 · see citing works
Assaf, W., Qarawani, A., Abboud, Y., Shalabna, E., Nahshon, C., Zilberlicht, A., Reiss, A., Schmidt, M., & Segev, Y. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70110 · Cited by 2 · see citing works
Harao, M., Ando, J., Kamata, H., Hoshi, N., Igarashi, S., Sekiguchi, R., & Sugano, K. (2017) · Breast Cancer · doi:10.1007/s12282-017-0813-9 · Cited by 2 · see citing works
Searching for the source: Extraovarian primary peritoneal carcinoma presenting as chest wall masses
Feng, M. B., Badiner, N. M., Hong, L., & Ioffe, Y. (2023) · Gynecologic Oncology Reports · doi:10.1016/j.gore.2023.101195 · Cited by 1 · see citing works
Smallwood, K. G., Crockett, S., Huang, V., Cullimore, V., Davies, J., Satti, G., & Phillips, A. (2022) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2022.2111253 · Cited by 1 · see citing works
Prophylactic oophorectomy in patients with increased risk of ovarian cancer
Németh, K., Koppán, M., Zámbó, K., & Bódis, J. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.04.003
The Psychosocial Impact of Prophylactic Mastectomy and Salpingo-Oophorectomy
Bresser, P. J. C. (2009) · RePub (Erasmus University Rotterdam)
Salant, T., & Lauderdale, D. S. (2006) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2006.06.004
Comparison of Gray Scale Ultrasound and POP-Q System in the Quantification of Pelvic Organ Prolapse
Gregorio, G. L., & Pangilinan, N. C. P. (2010)
Prophylactic Oophorectomy for Patients with Germline BRCA Mutations
Roque, D. R., & Dizon, D. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-59198-8_5
Risk-Reducing Breast and Ovarian Surgery for Women at High Familial Risk
Schultz, I., & Sandelin, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-56673-3_7
Ma, Y., Bu, H., Jin, C., Wang, X., Zhang, Y., & Zhang, H. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i22.3872
Genetic Counseling in the Follow-up of Breast Cancer patients; Conversion of a Luminal Tumor to TNBC
Ahmadi, H., Hosseinpour, R., Jahanbin, B., Majidzadeh‐A, K., & Ardalan, F. A. (2020) · Archives of Breast Cancer · doi:10.32768/abc.20207110-13
Połocka-Molińska, M., Plagens-Rotman, K., Trusz, W., Gwoździcka-Piotrowska, M., Jarząbek‐Bielecka, G., Molińska-Kulesza, A., & Kędzia, W. (2021) · Pielegniarstwo XXI wieku / Nursing in the 21st Century · doi:10.2478/pielxxiw-2021-0016
Prophylactic Bilateral Salpingo-oophorectomy
Ghosh, B., Glover, A. T., & Prosser‐Snelling, E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108582322.060
Hereditary gynecologic tumors and precision cancer medicine
Ogawa, C., Hirasawa, A., Ida, N., Nakamura, K., & Masuyama, H. (2022) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15197
(2006) · Springer eBooks · doi:10.1007/978-3-540-36854-0_17
Deep ulcerated lesion on hard palate
Gonçalves, D. R., Braun, L. W., Fernandes, A. C. P., Martins, M. A. T., Martins, M. D., & Carrard, V. C. (2024) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2023.12.797
Mor‐Hadar, D., McNally, O., Grant, A., Rajadevan, N., McBain, R. D., Naaman, Y., Chan, F., Vicario, E., & Wrede, C. D. (2025) · Surgical Oncology · doi:10.1016/j.suronc.2025.102193
Gynecologic Cancer: Risk Factors, Interception and Prevention
Samimi, G., & Heckman‐Stoddard, B. M. (2026) · Cancers · doi:10.3390/cancers18081235
Hereditary Carcinoma of the Ovary, Fallopian Tubes, and Peritoneum
Porcayo, M. A. T. (2026) · Springer eBooks · doi:10.1007/978-3-032-13454-7_35
Surgical Management of Hereditary Breast and Ovarian Cancer
Specht, M. C., Carmen, M. G. D., & Smith, B. L. (2010) · Springer eBooks · doi:10.1007/978-0-387-93846-2_4
- Authors
- Dowdy, S. C., Stefanek, M., & Hartmann, L. C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Dowdy, Sean C.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 191
- Issue
- 4
- Pages
- 1113-1123
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2117250748
- Cited by
- 61
- References
- 78
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- prophylactic salpingo-oophorectomy, prophylactic mastectomy, hereditary breast and ovarian cancer, BRCA1, BRCA2, risk mitigation, surgical complications, psychosocial impact, treatment guidelines, young women
- MeSH terms
- Breast Neoplasms, Decision Making, Fallopian Tubes, Female, Heterozygote, Humans, Mastectomy, Mutation, Ovarian Neoplasms, Ovariectomy, Risk Assessment, Genes, BRCA1, Genes, BRCA2
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