Cited by 61BRCA gene mutations in cancerCancer Risks and FactorsWomen's cancer prevention and management

Surgical risk reduction: Prophylactic salpingo-oophorectomy and prophylactic mastectomy

Dowdy, Sean C., Stefanek, Michael, Hartmann, Lynn C.·2004·American Journal of Obstetrics and Gynecology

Abstract

Investigators have used retrospective and prospective study designs to provide much needed data on the extent of risk reduction after prophylactic oophorectomy and mastectomy in women at increased risk for breast and ovarian cancer. In this publication we identify those women who may wish to consider prophylactic surgery, review data demonstrating the efficacy of prophylactic surgery, and discuss potential surgical complications. We also present data about the frequency of use and psychosocial impact of prophylactic surgery in this typically young group of women. Finally, we provide general treatment guidelines for the practicing clinician.

Integrity signals

Registry

Crossref · 10.1016/j.ajog.2004.04.028

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74 of 74 references verified0 citation errors · 0 not checkable

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Authors
Dowdy, S. C., Stefanek, M., & Hartmann, L. C.
Affiliations
National Institutes of Health (US)
Corresponding author
Dowdy, Sean C.
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2004-10
Volume
191
Issue
4
Pages
1113-1123
ISSN
0002-9378 (ISSN-L)
OpenAlex
W2117250748
Cited by
61
References
78
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords
prophylactic salpingo-oophorectomy, prophylactic mastectomy, hereditary breast and ovarian cancer, BRCA1, BRCA2, risk mitigation, surgical complications, psychosocial impact, treatment guidelines, young women
MeSH terms
Breast Neoplasms, Decision Making, Fallopian Tubes, Female, Heterozygote, Humans, Mastectomy, Mutation, Ovarian Neoplasms, Ovariectomy, Risk Assessment, Genes, BRCA1, Genes, BRCA2

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