Cited by 2,229BRCA gene mutations in cancerMultiple and Secondary Primary CancersCancer Risks and Factors

Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

King, Mary-Claire, Marks, Joan H., Mandell, Jessica B.·2003·Science

Abstract

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 . We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset.

Integrity signals

Registry

Crossref · 10.1126/science.1088759

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
King, M.-C., Marks, J. H., & Mandell, J. B.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
  • King, Mary-Claire
  • Mandell, Jessica B.
Venue
Science
Published
2003-10-24
Volume
302
Issue
5645
Pages
643-646
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2087025655
Cited by
2,229
References
28
Citations by year
2026: 34 · 2025: 49 · 2024: 54 · 2023: 94 · 2022: 85 · 2021: 94 · 2020: 111 · 2019: 99 · 2018: 102 · 2017: 112 · 2016: 118 · 2015: 140 · 2014: 120 · 2013: 116 · 2012: 127
FWCI
46.86
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
  • Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
BRCA1, BRCA2, hereditary breast cancer, hereditary ovarian cancer, lifetime cancer risk, Ashkenazi Jewish women, mutation carriers, family history (medicine), physical activity, adolescent obesity, age at cancer onset
MeSH terms
Alleles, Breast Neoplasms, Family, Fathers, Female, Genotype, Heterozygote, Humans, Jews, Life Style, Male, Mutation, Obesity, Ovarian Neoplasms, Risk, Time Factors, Cohort Studies, Exercise, Incidence, Age of Onset, Risk Assessment, Genes, BRCA1, Penetrance, Genetic Predisposition to Disease, Genes, BRCA2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review