Treatment of Non-Albicans Candida Vaginitis with Amphotericin B Vaginal Suppositories

Phillips, Albert John

doi:10.1016/j.ajog.2005.03.034

Cited by 66Antifungal resistance and susceptibilityReproductive tract infections researchOcular Infections and Treatments

Treatment of Non-Albicans Candida Vaginitis with Amphotericin B Vaginal Suppositories

Phillips, Albert John·2005·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2005.03.034

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Abstract

Objective This study was undertaken to investigate whether amphotericin B vaginal suppositories would be effective in the treatment of non- albicans Candida vaginitis in women who failed conventional therapy.Study design Thirty-two patients were identified with non- albicans Candida vaginitis. These patients were treated with conventional antifungal agents. Ten patients had persistence of the non- albicans Candida infection after treatment. Amphotericin B 50-mg vaginal suppositories were given nightly for 14 days to this subgroup of treatment failures.Results Of 10 women, 8 (80%) who were treated with amphotericin B vaginally initially showed no further infection. One of the treatment successes had 2 recurrences and responded to a second course of amphotericin B but failed a third course. If this patient is considered a treatment failure, then amphotericin B vaginal suppositories were successful in 70% of patients. The medication was well tolerated and local side effects were minimal.Conclusion Amphotericin B vaginal suppositories are a viable treatment option for refractory vaginitis caused by non- albicans Candida .

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In a study of 10 patients with non-albicans infection, 8 showed no further infection after treatment with 50 mg amphotericin B vaginal suppositories for 14 days.
“What is more, in the study conducted by Philipps between 1995 and 2004, 10 patients identified with non-albicans (9 with C. glabrata and 1 with C. tropicalis) infection were treated with 50 mg amphotericin B vaginal suppositories for 14 days, and after that, 8 of them showed no further infection (2 who failed were infected with C. glabrata) [43].”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [43]

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DI-066 Topical amphotericin b used in candida krusei vaginitis refractory treatment
de Vega, E. C., Gil-Navarro, M., Rubio, M. S., Perez-Blanco, J.-L., Blanco, G. B., & González-Bueno, J. (2015) · doi:10.1136/ejhpharm-2015-000639.241
REFRACTORY FUNGAL VAGINITIS TREATED BY TOPICAL AMPHOTERICIN B. Review
Al-Khikani, F. H. O. (2020) · Medical Science of Ukraine (MSU) · doi:10.32345/2664-4738.2.2020.10 · Cited by 2 · see citing works
The study of vaginal candidiasis with Miconazole suppositories and nystatin suppository
Yu-zhe, X. (2011) · Chinese Journal of Modern Drug Application

Authors: Phillips, A. J.
Affiliations: University of Southern California (US)
Corresponding author: Phillips, Albert John
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2005-06
Volume: 192
Issue: 6
Pages: 2009-2012
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2005.03.034
OpenAlex: W2113992587
Cited by: 66
References: 22
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 5
FWCI: 1.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords: amphotericin B, vaginal suppositories, treatment failure, antifungal therapy, Candida, treatment efficacy, recurrence
MeSH terms: Administration, Intravaginal, Adult, Aged, Amphotericin B, Antifungal Agents, Candida, Candidiasis, Vulvovaginal, Female, Humans, Middle Aged, Treatment Outcome

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Treatment of Non-Albicans Candida Vaginitis with Amphotericin B Vaginal Suppositories

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