Vulvovaginal candidosis: contemporary challenges and the future of prophylactic and therapeutic approaches
Abstract
Summary: Vulvovaginal candidosis (VVC) is a common gynaecological disorder that is delineated by the inflammation of vaginal wall and it is caused by the opportunistic fungal pathogen Candida species. In fact, three out of every four women will experience at least one occasion of VVC during some point in their lives. Although uncomplicated VVC is relatively harmless, the complicated VVC such as recurrent attack often creates restlessness and depression in the patients, thus greatly affects their quality of life. Managements of VVC are usually associated with the use of antimycotic suppositories, topical cream or oral agents. These antimycotic agents are either available over‐the‐counter or prescribed by the clinicians. In recent decades, the rise of clinical challenges such as the increased prevalence of resistant Candida strains, recurrent VVC infection and adverse effects of multidrug interactions have necessitated the development of novel therapeutic or prophylactic options to combat the complicated VVC in the future. In this review, we discuss the current antimycotic treatments available for Candida vaginitis and the problems that exist in these seemingly effective treatments. Besides, we attempt to contemplate some of the future and prospective strategies surrounding the development of alternative therapeutic and prophylactic options in treating and preventing complicated VVC respectively.
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Treatment of VVC in pregnant women is necessary because it can prevent a lower birth weight of the fetus or a premature delivery.
“Treatment of VVC in pregnant women is necessary because it can prevent a lower birth weight of the fetus or a premature delivery [69].”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [69]
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Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods
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- Authors
- Chew, S. Y., & Than, L. T. L.
- Affiliations
- Universiti Putra Malaysia (MY)
- Corresponding author
- Than, Leslie Thian Lung
- Venue
- Mycoses
- Publisher
- Wiley
- Published
- 2016-01-13
- Volume
- 59
- Issue
- 5
- Pages
- 262-273
- ISSN
- 0027-5557 (ISSN-L)
- 0933-7407
- 1439-0507
- OpenAlex
- W2233314156
- Cited by
- 63
- References
- 12
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 16 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mycoses (publishedVersion)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- vaginal candidiasis, Candida vaginitis, recurrent vulvovaginal candidiasis, antifungal prophylaxis, antifungal therapy, antifungal resistance, Candida, adverse drug interactions, quality of life
- MeSH terms
- Administration, Oral, Administration, Topical, Antifungal Agents, Candida, Candidiasis, Vulvovaginal, Drug Interactions, Nonprescription Drugs, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Recurrence, Drug Resistance, Fungal
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