The influence of maternal cigarette smoking on placental pathology in pregnancies complicated by abruption
Open accessAbstract
Objective The purpose of this study was to evaluate the effect of maternal cigarette smoking on placental histology in women with abruption.Study design Data were derived from the New Jersey-Placental Abruption Study (NJ-PAS)--an ongoing, case-control study, conducted since August 2002 in 2 large hospitals in NJ. Abruption cases were identified based on a clinical diagnosis. Histologic evaluations were performed by 2 perinatal pathologists who were blinded to the abruption status. Maternal smoking during pregnancy was determined based on patient's self-report. Among abruption cases, histologic findings were compared between smokers and nonsmokers, and the association expressed as odds ratio (OR) with 95% confidence interval (CI). All analyses were adjusted for potential confounders.Results A total of 189 abruption cases were available for analysis, of which 10.6% (n = 20) were smokers. Intervillous thrombus was more common in women who smoked (20%) than in nonsmokers (3.0%) (OR, 17.5; 95% CI, 3.1-99.4). However, placental infarcts were seen less frequently among smokers than nonsmokers (10.0% vs 32.5%; OR, 0.2; 95% CI, 0.1-0.8).Conclusion These findings suggest that different pathologic mechanisms may be responsible for the histologic findings between smokers and nonsmokers diagnosed with placental abruption.
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Tobacco smoking is associated with a 1.7 to 2-fold increased risk of abruption, with a strong dose-response association between the number of cigarettes smoked per day.
“Tobacco smoking is associated with a 1.7 to 2-fold increased risk of abruption, with a strong dose-response association between the number of cigarettes smoked per day (39–41).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [41]
The passage labeled Conclusion reports relative risks of 1.4–2.5 for smoking and placental abruption, encompassing the claimed 1.7–2-fold increase. It also says risk rises with cigarettes smoked per day, but levels off at approximately 10 cigarettes per day; the claim’s unqualified description of a strong dose-response association omits that limit. (LLM, conf=0.86)
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- Authors
- Kaminsky, L. M., Ananth, C. V., Prasad, V., Nath, C., & Vintzileos, A. M.
- Affiliations
- Arkansas Children's Hospital (US)
- Corresponding author
- Ananth, Cande V.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 197
- Issue
- 3
- Pages
- 275.e1-275.e5
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC2175535
- OpenAlex
- W2037630756
- Cited by
- 49
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 7 · 2015: 1 · 2013: 1
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD038902, R01HD038902)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- maternal cigarette smoking, placental abruption, placental pathology, placental histology, placental infarction, smoking during pregnancy
- MeSH terms
- Abruptio Placentae, Adult, Female, Humans, Placenta, Pregnancy, Smoking, Case-Control Studies, Prenatal Injuries
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