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Cited by 126Maternal and fetal healthcarePregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

Placental abruption: Maternal risk factors and associated fetal conditions

Raymond, Elizabeth G., Mills, James L.·1993·Acta Obstetricia Et Gynecologica Scandinavica
DOI 10.3109/00016349309021156
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Abstract

OBJECTIVE: To investigate maternal risk factors and fetal conditions associated with abruption. METHODS: Prospective cohort study of 30,681 singleton pregnancies at least 28 weeks' gestation. Data collected by patient questionnaire at the first prenatal visit and by medical record review. RESULTS: 307 women had abruption (1%). After adjustment, important maternal risk factors included age (in years; OR 1.03; 95% CL 1.00, 1.06; p = 0.04) and less than 12 years of education (OR 1.58; 95% CL 1.10, 2.25; p = 0.01). Each pack of cigarettes smoked per day increased the risk by approximately 40% (OR 1.39; 95% CL 1.09, 1.79; p = 0.009). If abruption occurred, the perinatal mortality rate was substantially higher in women who smoked at least one pack per day than in nonsmokers (RR 2.53; 95% CL 1.14, 5.61; p = 0.02). Abruption was also significantly associated with intrauterine growth retardation and fetal malformations. The increased malformation rate was due entirely to nearly a five-times increase in congenital heart defects (OR 4.63; 95% CL 2.49, 8.55; p = 0.00000014). CONCLUSIONS: Heavier smoking increases the risk both of abruption and of perinatal death when abruption occurs. If the association between abruption and congenital heart defects is confirmed, early evaluation could lead to more prompt treatment of these malformations in infants delivered after abruption.

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Authors
Raymond, E. G., & Mills, J. L.
Affiliations
National Institutes of Health (US)
Corresponding author
Raymond, Elizabeth G.
ORCID
Mills, James L.
Venue
Acta Obstetricia Et Gynecologica Scandinavica
Publisher
Wiley
Published
1993-11
Volume
72
Issue
8
Pages
633-639
ISSN
  • 0001-6349 (ISSN-L)
  • 1600-0412
DOI
10.3109/00016349309021156
OpenAlex
W2067124185
Cited by
126
References
25
Citations by year
2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 6
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6276 d)
Locations
  • Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
placental abruption, maternal risk factors, maternal smoking, perinatal mortality, congenital heart disease, fetal growth restriction, fetal malformations, maternal age, maternal education, singleton pregnancy
MeSH terms
Congenital Abnormalities, Abruptio Placentae, Adult, Alcohol Drinking, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Maternal Age, Pregnancy, Prospective Studies, Risk Factors, Smoking, Socioeconomic Factors, Cohort Studies

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