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Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus
Open accessAbstract
Objective Changes in metabolic homeostasis in pregnant diabetic women are potential determinants of increased adiposity of the fetus. The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study design Placentas of women with type 1 diabetes mellitus, gestational diabetes mellitus (GDM), or no complications were analyzed by microarray profiling. The pattern of gene expression was assessed in primary placental cell cultures. Results Diabetes mellitus was associated with 49 alterations in gene expression at key steps in placental energy metabolism, with 67% of the alterations related to lipid pathways and 9% of the alterations related to glucose pathways. Preferential activation of lipid genes was observed in pregnancy with GDM. Type 1 diabetes mellitus induced fewer lipid modifications but an enhancement of glycosylation and acylation pathways. Oleate enhanced expression of genes for fatty acid esterification and the formation of lipid droplets 3 times as much as glucose in cultured placental cells. Conclusion These results point to fatty acids as preferential lipogenic substrates for placental cells and suggest that genes for fetoplacental lipid metabolism are enhanced selectively in GDM. The recruited genes may be instrumental in increasing transplacental lipid fluxes and the delivery of lipid substrates for fetal use.
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“The majority of placental gene expression alterations in GDM occur in lipid pathways (67%), as compared with glucose pathways (9%) [152].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [152]
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“Preferential activation of placental lipid genes is also associated with GDM compared with T1DM [152].”
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The Pathophysiology of Gestational Diabetes Mellitus
Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113342 · Cited by 1,874
“Increased “free” plasma/serum ZO-1 is associated with type 1 diabetes (T1DM), T2DM [134], and GDM [135].”
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Self-citationPerinatal risk factors for childhood obesity and metabolic dysregulation
Catalano, P. M., Farrell, K., Thomas, A., Huston-Presley, L., Mencin, P., de Mouzon, S. H., & Amini, S. B. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27416 · Cited by 553
“These alterations in insulin sensitivity in obese pregnant women result in a greater availability of nutrients, such as glucose and lipids, which are preferential energy sources and substrates for feto-placental growth (31).”
BackgroundSelf-citationMaternal obesity and fetal metabolic programming: a fertile epigenetic soil
Heerwagen, M. J. R., Miller, M. R., Barbour, L. A., & Friedman, J. E. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00310.2010 · Cited by 544
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“Consistent with these clinical observations, Radaelli et al. (2009) have reported that enzymes related to intermediary lipid metabolism in contrast to glucose are increased in placenta of obese GDM women.”
ResultSelf-citationMaternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta
Brett, K., Ferraro, Z. M., Yockell‐Lelièvre, J., Gruslin, A., & Adamo, K. B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916153 · Cited by 459
“FABP4 ▲ mRNA (birth weight > control; not macrosomic) [94] ▲ mRNA (birth weight > control; not macrosomic) [94] ▬ (no difference in birth weight) [99] ▲ (with diabetes) (birth weight > control; not macrosomic) [99] ▬ mRNA (birth weight > control; not macrosomic) [96]”
BackgroundInfluentialIs it time to revisit the Pedersen hypothesis in the face of the obesity epidemic?
Catalano, P. M., & Mouzon, S. H. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.11.039 · Cited by 341
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Self-citationDisturbances in lipid metabolism in diabetic pregnancy – Are these the cause of the problem?
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“Studies have also demonstrated major changes in the placental gene expression profile of inflammatory genes in women who have developed gestational diabetes mellitus (GDM; Radaelli et al. 2009).”
The offspring of the diabetic mother – Short- and long-term implications
Mitanchez, D., Yzydorczyk, C., Siddeek, B., Boubred, F., Benahmed, M., & Siméoni, U. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2014.08.004 · Cited by 223
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ResultPrieto‐Sánchez, M. T., Ruíz‐Palacios, M., Blanco‐Carnero, J. E., Pagán, A., Hellmuth, C., Uhl, O., Peißner, W., Ruiz‐Alcaraz, A. J., Parrilla, J. J., Koletzko, B. V., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.01.014 · Cited by 113
“increases in EL [25], and even reduction in placental LPL [26] in GDM were reported.”
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“acids and lipids that may diminish (11) or enhance (57) their”
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“These findings have prompted the notion that placental lipid metabolism may represent a regulatory step toward fetal macrosomia (14, 34, 39, 41).”
BackgroundInfluentialCurrent understanding of placental fatty acid transport
Gil-Sánchez, A., Koletzko, B. V., & Larqué, E. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283523b6e · Cited by 97
“Nevertheless, available results on placental LPL and endothelial lipase levels in GDM patients are inconclusive, maybe because of the low number of patients in such studies; no changes [37,38], increases in endothelial lipase but not in LPL [25], and even a reduction in placental LPL [39] to counteract excessive place…”
BackgroundMaternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition
Segura, M. T., Demmelmair, H., Krauss‐Etschmann, S., Nathan, P., Dehmel, S., Padilla, M. C., Rueda, R., Koletzko, B. V., & Campoy, C. (2017) · Placenta · doi:10.1016/j.placenta.2017.07.001 · Cited by 110
Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus
Pagán, A., Prieto‐Sánchez, M. T., Blanco‐Carnero, J. E., Gil-Sánchez, A., Parrilla, J. J., Demmelmair, H., Koletzko, B. V., & Larqué, E. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00291.2013 · Cited by 100
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“It is accepted that regulation of these genes in GDM alters placenta and fetus lipid metabolism leading to altered fetal development and size, a condition potentiating fetal hyperinsulinemia’s biological effects and contributing to the development of the metabolic syndrome and CVD later in life [79, 96].”
BackgroundReview: Placental transport and metabolism of energy substrates in maternal obesity and diabetes
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“Prior studies have assessed the impact of GDM on genome-wide expression patterns in the placenta, in both the fetal and maternal side, with numbers of diagnosed cases ranging from 2 to 19 [21–24].”
BackgroundPathmaperuma, A., Mana, P. M., Cheung, S. N., Kugathas, K., Josiah, A., Koina, M. E., Broomfield, A., Delghingaro‐Augusto, V., Ellwood, D. A., Dahlstrom, J. E., et al. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.013 · Cited by 77
“A recent study suggested that lipid metabolism genes in placenta are altered in different patterns in gestational diabetes and type 1 diabetes [28].”
BackgroundResultInfluentialMaternal obesity and prenatal programming
Elshenawy, S., & Simmons, R. A. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.002 · Cited by 72
“Furthermore, a gene expression study by Radaelli et al, demonstrated significant alterations in genes involved in lipid metabolism in the placentas of mothers with gestational and type 1 diabetes mellitus [42].”
BackgroundPlacental Fatty Acid Transfer: A Key Factor in Fetal Growth
Larqué, E., Pagán, A., Prieto‐Sánchez, M. T., Blanco‐Carnero, J. E., Gil-Sánchez, A., Moreno, M. Z., Ruíz‐Palacios, M., Gázquez, A., Demmelmair, H., Parrilla, J. J., et al. (2014) · Annals of Nutrition and Metabolism · doi:10.1159/000365028 · Cited by 82
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Newborn Body Fat: Associations with Maternal Metabolic State and Placental Size
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“These findings are in accordance with previous studies and the notion of placenta as a nutrient sensor [32,33].”
ResultRole of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus
Ruíz‐Palacios, M., Ruiz‐Alcaraz, A. J., Sánchez-Campillo, M., & Larqué, E. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000455904 · Cited by 83
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“Genes for lipids and AA transport are upregulated in the placenta of women with GDM more than those for glucose, as are genes for inflammatory pathways (22,23).”
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“At 5 years of age, DNAm measured at CpG sites within R1 were no longer associated with GDM.”
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“Since maternal obesity increases placental lipid accumulation which is associated with fetal adiposity [21], increasing the availability of choline may attenuate placental lipid overload and reduce lipid transport to the fetus.”
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Sobrevía, L., Salsoso, R., Fuenzalida, B., Barros, E., Toledo, L., Silva, L., Pizarro, C., Subiabre, M., Villalobos-Labra, R., Henríquez, J. A., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00119 · Cited by 57
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Current approaches and developments in transcript profiling of the human placenta
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Effect of Excess Gestational Weight Gain on Pregnancy Outcomes in Women With Type 1 Diabetes
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“A few reports of placental histological findings in obese women described infiltration of pro-inflammatory macrophages [10, 24], and one study demonstrated major changes in the expression profile of placental inflammatory genes in women with gestational diabetes mellitus [25].”
BackgroundResi, V., Basu, S., Haghiac, M., Presley, L. H., Minium, J., Kaufman, B. R., Bernard, S. L., Catalano, P. M., & Mouzon, S. H. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00002.2012 · Cited by 47
Self-citationMrizak, I., Arfa, A., Fekih, M., Debbabi, H., Bouslema, A., Boumaiza, I., Zaouali, M., Khan, N. A., & Tabka, Z. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-93 · Cited by 44
Andreassen, O. A., Desikan, R. S., Wang, Y., Thompson, W. K., Schork, A. J., Zuber, V., Doncheva, N. T., Ellinghaus, E., Albrecht, M., Mattingsdal, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123057 · Cited by 39
“The strong polygenic pleiotropy between lipids and T1D also supports a role of lipid pathobiology, as shown in relation to insulin secretion[49], diabetes risk[50] and pathology [51].”
BackgroundObesity in mares promotes uterine inflammation and alters embryo lipid fingerprints and homeostasis†
Sessions, D. R., Heuberger, A. L., & Carnevale, E. M. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy107 · Cited by 49
BMI-Independent Effects of Gestational Diabetes on Human Placenta
Stirm, L., Kovářová, M., Perschbacher, S., Michlmaier, R., Fritsche, L., Siegel-Axel, D. I., Schleicher, E. D., Peter, A., Pauluschke‐Fröhlich, J., Brucker, S. Y., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00397 · Cited by 40
Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application
Ibarra, A., Guedes, B. V., Brito‐Casillas, Y., & Wägner, A. M. (2018) · Non-Coding RNA · doi:10.3390/ncrna4040032 · Cited by 39
“A small study assessing placental gene expression (using a metabolic gene array) in women with type 1 diabetes, obese women with gestational diabetes and women without diabetes, showed differential regulation of lipid-metabolism related genes in the women with gestational diabetes [46].”
BackgroundShen, S., Lu, J., Zhang, L., He, J., Li, W., Chen, N., Wen, X., Xiao, W., Yuan, M., Qiu, L., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.025 · Cited by 40
Insulin Treatment May Alter Fatty Acid Carriers in Placentas from Gestational Diabetes Subjects
Ruíz‐Palacios, M., Prieto‐Sánchez, M. T., Ruiz‐Alcaraz, A. J., Blanco‐Carnero, J. E., Sánchez-Campillo, M., Parrilla, J. J., & Larqué, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061203 · Cited by 37
“but using a low number of subjects and without considering the mode of GDM treatment (diet or insulin) [8,9], which may influence lipid transport.”
Evangelista, A. F., Collares, C. V. A., Xavier, D. J., Macedo, C., Manoel-Caetano, F. S., Rassi, D. M., Foss‐Freitas, M. C., Foss, M. C., Sakamoto‐Hojo, E. T., Nguyen, C., et al. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-28 · Cited by 36
“In addition, transcriptome signatures obtained from placenta [38] and whole blood cells [39] have identified genes involved with lipid metabolism that are differentially expressed between T1D and GDM.”
BackgroundExpression of nutrient transporters in placentas affected by gestational diabetes: role of leptin
Guadix, P., Corrales-Gutiérrez, I., Vilariño‐García, T., Rodríguez-Chacón, C., Sánchez-Jiménez, F., Jiménez‐Cortegana, C., Dueñas, J. L., Sánchez‐Margalet, V., & Pérez‐Pérez, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1172831 · Cited by 37
O’Tierney-Ginn, P., Roberts, V. H. J., Gillingham, M. B., Walker, J., Glazebrook, P. A., Thornburg, K. L. R., Grove, K. L., & Frias, A. E. (2015) · Placenta · doi:10.1016/j.placenta.2015.06.002 · Cited by 33
“Maternal high fat diet [5,6] and maternal insulin resistance [13,14] alter placental fatty acid metabolism and transport and are associated with maternal obesity.”
Gajera, D., Trivedi, V., Thaker, P., Rathod, M., & Dharamsi, A. T. (2023) · Hormone and Metabolic Research · doi:10.1055/a-2061-9441 · Cited by 36
“When compared to glucose pathways (9 %), lipid pathways (67 %) account for the majority of changes in placental gene expression in GDM [18].”
BackgroundDiabetes Mellitus, Obesity, and the Placenta
Desoyé, G., & Cervar-Zivkovic, M. (2019) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2019.11.001 · Cited by 35
Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease
Myatt, L., & Thornburg, K. L. R. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_2 · Cited by 36
Infant of diabetic mother: what one needs to know?
Kallem, V. R., Pandita, A., & Pillai, A. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1494710 · Cited by 38
Maternal obesity and offspring health: Adapting metabolic changes through autophagy and mitophagy
Wang, L., O’Kane, A., Zhang, Y., & Ren, J. T. (2023) · Obesity Reviews · doi:10.1111/obr.13567 · Cited by 37
“proteins for transport and activation of FAs and intracellular lipid biosynthesis were upregulated in the placenta.(130) Reminiscent of adipose tissues, the placenta from obese pregnancy exhibited macrophage accumulation and boosted inflammation in an analogous manner.”
ResultRousseau‐Ralliard, D., Couturier‐Tarrade, A., Thieme, R., Brat, R., Rolland, A., Boileau, P., Aubrière, M.-C., Daniel, N., Dahirel, M., Derisoud, E., et al. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.10.010 · Cited by 31
Foeller, M. E., Zhao, S., Szabó, A., & Cruz, M. O. (2015) · Journal of Perinatology · doi:10.1038/jp.2015.133 · Cited by 30
Nikolova, V., Papacleovoulou, G., Bellafante, E., Manna, L. B., Jansen, E. H. J. M., Baron, S., Abu‐Hayyeh, S., Parker, M. G., & Williamson, C. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00449.2016 · Cited by 29
Manoharan, B., Bobby, Z., Dorairajan, G., Jacob, S. E., Gladwin, V., Vinayagam, V., & Packirisamy, R. M. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1017-3182 · Cited by 23
Moschonis, G., Kaliora, A. C., Karatzi, K., Michaletos, A., Lambrinou, C. P., Karachaliou, A., Chrousos, G. P., Lionis, C. D., & Μanios, Y. (2016) · Public Health Nutrition · doi:10.1017/s1368980016002640 · Cited by 21
“One hypothesis is that during pregnancy of an obese mother, pathways for intracellular lipid biosynthesis are selectively up-regulated((19)).”
Judge, M. P., Casavant, S. G., Dias, J. A. M., & McGrath, J. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw006 · Cited by 19
“Collectively, these results support the need for further investigation of the role of placental lipoprotein lipase activity in diabetic pregnancy.(36,75,76) Investigation of the impact of reduced endothelial lipase activity on placental fatty acid transport in diabetic pregnancy is also warranted.”
BackgroundResultDiabetic pregnancy, maternal and fetal docosahexaenoic acid: a review of existing evidence
Léveillé, P., Rouxel, C., & Plourde, M. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1314460 · Cited by 23
“Indeed, genes for the transport and activation of FAs and low-density lipoproteins were upregulated in the placenta of T1D mothers compared to ND mothers [17].”
BackgroundResultLinask, K. K., & Han, M. (2016) · Birth defects research. Clinical and molecular teratology · doi:10.1002/bdra.23526 · Cited by 20
“5, the different trophoblast lineages are differentiating (Rossant and Cross, 2001).”
Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes
Périmenis, P., Bouckenooghe, T., Delplanque, J., Moitrot, E., Eury, E., Lobbens, S., Gosset, P., Devisme, L., Duvillié, B., Abderrahmani, A., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.026 · Cited by 22
“MD induces damage to placenta [7,8] but the molecular mechanisms involved are still elusive.”
BackgroundLeiva, A., de Medina, C. D., Guzmn-Gutirrez, E., Pardo, F., & Sobrevi, L. (2013) · InTech eBooks · doi:10.5772/55297 · Cited by 16
“The increased levels of maternal cholesterol in GDM (Table 3) are related with alterations in the expression of proteins involved in lipid and cholesterol homeostasis [24,150,151].”
BackgroundResultDoes Maternal Body Mass Index Influence Treatment Effect in Women with Mild Gestational Diabetes?
Mele, L., Landon, M. B., Spong, C. Y., Ramin, S. M., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., Catalano, P., Harper, M., et al. (2014) · American Journal of Perinatology · doi:10.1055/s-0034-1374815 · Cited by 17
Self-citationHuhtala, M. S., Tertti, K., & Rönnemaa, T. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108456 · Cited by 16
Podratz, P. L., Merlo, E., de Araújo, J. F. P., Ayub, J. G. M., Pereira, A. F. Z., Freitas‐Lima, L. C., da Costa, M. B., Miranda‐Alves, L., Cassa, S. G. S., Carneiro, M. T. W. D., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138000 · Cited by 24
Insulin Resistance in Pregnancy: Implications for Mother and Offspring
Hernandez, T. L., Friedman, J. E., & Barbour, L. A. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_5 · Cited by 19
Gázquez, A., Uhl, O., Ruíz‐Palacios, M., Gill, C. A., Patel, N., Koletzko, B. V., Poston, L., & Larqué, E. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.04.020 · Cited by 16
“These can be synthesized de novo from glucose, but also from non-esterified FAs (NEFAs); enhanced FA esterification and TG deposition in placenta LD has been reported following incubation with NEFAs [32-34] which show a higher capacity to influence FA deposition than glucose or insulin.”
BackgroundBariatric Surgery and the Pregnancy Complicated by Gestational Diabetes
Willis, K. A., Alexander, C., & Sheiner, E. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0716-8 · Cited by 16
Stanirowski, P. J., Wątroba, M., Pyźlak, M., Wejman, J., & Szukiewicz, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063559 · Cited by 14
“Indeed, several genes related to lipid transport encoding EL, FABP4 and FABP5 are upregulated in the placentas of GDM/PGDM women and multiple studies have demonstrated alterations in the expression of the enzymes and proteins responsible for the uptake of FFA in a diabetic pregnancy [14–18].”
BackgroundKedziora, S. M., Obermayer, B., Sugulle, M., Herse, F., Kräker, K., Haase, N., Langmia, I. M., Müller, D. N., Staff, A. C., Beule, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315388 · Cited by 18
“The published analyses include small sample numbers (n = 3 and n = 6, respectively), which makes expression differences difficult to be identified [39,40].”
BackgroundRole of adipose tissue in regulating fetal growth in gestational diabetes mellitus
Nguyen‐Ngo, C., Jayabalan, N., Haghvirdizadeh, P., Salomón, C., & Lappas, M. (2020) · Placenta · doi:10.1016/j.placenta.2020.05.006 · Cited by 16
Bhushan, R., Rani, A., Ali, A., Singh, V. K., & Dubey, P. K. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107556 · Cited by 16
Maternal methyl donor supplementation: A potential therapy for metabolic disorder in offspring
Ren, Y., Zeng, Y., Wu, Y., Zhang, Q., & Xiao, X. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109533 · Cited by 17
Pinto, G. D. A., Murgia, A., Lai, C., Ferreira, C. S. T., Goes, V. D. A., Guimarães, D. D. A. B., Ranquine, L. G., Reis, D. L., Struchiner, C. J., Griffin, J. L., et al. (2022) · British Journal Of Nutrition · doi:10.1017/s000711452200397x · Cited by 15
“Additionally, the expression of placental genes related to fatty acid esterification and lipid droplet accumulation is higher(8), and higher amounts of microRNAs targeting insulin resistance pathways and lipid metabolism have been reported(9).”
BackgroundThe Origins of NAFLD: The Potential Implication of Intrauterine Life and Early Postnatal Period
Valentini, F., Rocchi, G., Gentilucci, U. V., Guarino, M. P. L., Altomare, A., & Carotti, S. (2022) · Cells · doi:10.3390/cells11030562 · Cited by 13
“demonstrated that trophoblast cells of GDM mothers show an expression of genes involved in fetoplacental lipid metabolism much more increased compared to glucose metabolism [25].”
BackgroundMassalha, M., Iskander, R., Hassan, H., Spiegel, E., Erez, O., & Nachum, Z. (2025) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2025.1527076 · Cited by 14
Shen, S., Žurauskienė, J., Wei, D., Chen, N., Lu, J., Kuang, Y., Liu, H., Cazier, J., & Qiu, X. (2021) · Endocrine · doi:10.1007/s12020-021-02787-x · Cited by 17
Ahlsson, F., Åkerud, H., Schijven, D., Olivier, J., & Poromaa, I. S. (2015) · Reproductive Sciences · doi:10.1177/1933719115578928 · Cited by 13
Maternal Hypertriglyceridemia in Gestational Diabetes: A New Risk Factor?
Puga, F. M., Duarte, D. B., Benido-Silva, V., Pereira, M., Garrido, S., Vilaverde, J., Moreira, M. S., Pichel, F., Pinto, C., & Dores, J. (2024) · Nutrients · doi:10.3390/nu16111577 · Cited by 12
“A recent study pointed to an over-representation of genes associated with placental lipid pathways (compared to those related to glucose metabolism) in GDM pregnancies, with a selective activation of transplacental lipid fluxes [26].”
BackgroundPavlidou, E., Papandreou, D., Taha, Z., Mantzorou, M., Tyrovolas, S., Kiortsis, D. N., Psara, E., Papadopoulou, S. Κ., Yfantis, M., Spanoudaki, M., et al. (2023) · Nutrients · doi:10.3390/nu15153384 · Cited by 17
“In support of the previous findings, the bio-physiological pathway of insulin resistance among overweight and obese mothers may lead, among other factors, to elevated glucose levels during gestation, which was linked with accelerated fetus development and large birth weight for newborns [34].”
ResultSilvares, E. Á., Fernández-Cruz, T., Domínguez-Vigo, P., Rubio-Cid, P., Seoane‐Pillado, T., & Martínez‐Carballo, E. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12377-z · Cited by 16
“…other hand, it has been demonstrated that lipid metabolism is altered in the placentas of women with GDM (Gauster et al. 2011; Radaelli et al. 2009; Radaelli et al. 2003), subsequent to abnormalities in the structure and function of placentas (such as gene and enzyme expression related to lipids),…”
BackgroundNi, L.-F., Han, Y., Wang, C., Yan, Y., Ding, M., Zheng, T., Wang, Y., Yan, H., & Yang, X. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00755-4 · Cited by 11
Placental 13C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight
Watkins, O. C., Selvam, P., Pillai, R. A., Cracknell-Hazra, V. K. B., Yong, H. E. J., Sharma, N., Cazenave‐Gassiot, A., Bendt, A. K., Godfrey, K. M., Lewis, R. M., et al. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00344-w · Cited by 12
Adipocytokines are not associated with gestational diabetes mellitus but with pregnancy status
Ebert, T., Gebhardt, C., Scholz, M. R., Schleinitz, D., Blüher, M., Stümvoll, M., Kovacs, P. L., Faßhauer, M., & Tönjes, A. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155088 · Cited by 15
“On the other hand, placental microarray data indicate that none of the five adipocytokines from component 1 is differentially expressed in the placenta from women with GDM as compared to pregnant women without GDM [27,28].”
BackgroundLiu, Y., Wang, Y., Wang, Y., Lv, Y., Zhang, Y.-X., & Wang, H.-Y. (2020) · Gynecological Endocrinology · doi:10.1080/09513590.2020.1712696 · Cited by 11
Metadata
- Authors
- Radaelli, T., Lepercq, J., Varastehpour, A., Basu, S., Catalano, P. M., & Hauguel-De Mouzon, S.
- Affiliations
- Hôpital Cochin (FR)
- MetroHealth Medical Center (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 201
- Issue
- 2
- Pages
- 209.e1-209.e10
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3613858
- OpenAlex
- W2039524521
- Cited by
- 156
- References
- 46
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 4 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 8
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Case Western Reserve University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 22965, R01HD022965)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- gestational diabetes mellitus, type 1 diabetes, placental gene expression, fetal adiposity, placental energy metabolism, fatty acid esterification, lipid droplets, oleate, glycosylation, acylation
- MeSH terms
- Adipose Tissue, Adult, Blood Glucose, Cells, Cultured, Diabetes Mellitus, Type 1, Energy Metabolism, Female, Fetus, Homeostasis, Humans, Obesity, Placenta, Pregnancy, Diabetes, Gestational, Gene Expression Regulation, Developmental, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Lipid Metabolism
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