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Cited by 200Prenatal Substance Exposure EffectsPregnancy and Medication ImpactYouth, Drugs, and Violence

Effects of cocaine use during pregnancy on low birthweight and preterm birth: systematic review and metaanalyses

Gouin, Katy, Murphy, Kellie, Shah, Prakesh S.·2011·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2010.11.013
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Abstract

Objective To review systematically maternal antenatal cocaine exposure and adverse perinatal outcomes.Study design Medline, Embase, CINAHL and secondary references in relevant studies were searched. English language studies of antenatal cocaine exposure and pregnancy outcomes published from 1966 to July 2009 were included. Metaanalyses were performed using the random effects model.Results Thirty-one studies were included. Cocaine use during pregnancy was associated with significantly higher odds of preterm birth (odds ratio [OR], 3.38; 95% confidence interval [CI], 2.72-4.21), low birthweight (OR, 3.66; 95% CI, 2.90-4.63), and small for gestational age infants (OR, 3.23; 95% CI, 2.43-4.30), as well as shorter gestational age at delivery (-1.47 week; 95% CI, -1.97 to -0.98 week) and reduced birthweight (-492 g; 95% CI, -562 to -421 g).Conclusion Prenatal cocaine exposure is significantly associated with preterm birth, low birthweight, and small for gestational age infants.

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  • Non-prescription and recreational drug use during pregnancy is associated with higher risks of foetal death, low birth weight, and preterm birth.

    “However, current data suggest that non-prescription and recreational drug use during pregnancy is associated with increased risk of foetal death, low birth weight, and preterm birth (Gouin 2011, Gunn 2016Ladhani 2011, Metz 2017).”

    From Preconception lifestyle advice for people with infertility (2021) · cites this paper as Gouin 2011

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Authors
Gouin, K., Murphy, K., & Shah, P. S.
Affiliations
Mount Sinai Hospital (CA)
Corresponding author
Gouin, Katy
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2011-04
Volume
204
Issue
4
Pages
340.e1-340.e12
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2010.11.013
OpenAlex
W2080673280
Cited by
200
References
47
Citations by year
2026: 12 · 2025: 12 · 2024: 18 · 2023: 10 · 2022: 13 · 2021: 16 · 2020: 16 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 8 · 2015: 8 · 2014: 17 · 2013: 11 · 2012: 14
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (KRS86242)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
  • Social Sciences › Demography › Youth, Drugs, and Violence
Keywords
cocaine use during pregnancy, prenatal cocaine exposure, preterm birth, low birth weight, small for gestational age, gestational age, perinatal outcomes, maternal substance use
MeSH terms
Birth Weight, Cocaine, Female, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age, Narcotics, Pregnancy, Prenatal Exposure Delayed Effects, Odds Ratio, Cocaine-Related Disorders, Premature Birth

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