The risk of intrauterine fetal death in the small-for-gestational-age fetus
Open accessAbstract
Objective We sought to evaluate the risk of intrauterine fetal death (IUFD) in small-for-gestational-age (SGA) fetuses.Study design We analyzed a retrospective cohort of all births in the United States in 2005, as recorded in a national database. We calculated the risk of IUFD within 3 sets of SGA threshold categories as well as within non-SGA pregnancies using the number of at-risk fetuses as the denominator.Results The risk of IUFD increased with gestational age and was inversely proportional to percentile of birthweight for gestational age. The risk for IUFD in those <3rd percentile was as high as 58.0 IUFDs per 10,000 at-risk fetuses, 43.9 for <5th percentile, and 26.3 for <10th percentile compared to 5.1 for non-SGA gestations.Conclusion There is an increase in the risk of IUFD in SGA fetuses compared to non-SGA fetuses at all gestational ages with the greatest risk demonstrated in the lowest percentile cohort evaluated.
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In a large retrospective cohort of more than 3 million singleton pregnancies, the risk of stillbirth at birthweights of less than the 3rd percentile was increased approximately 3-fold over the 3rd to 5th percentile group at nearly all gestational ages, and there was an increased risk of 4-fold to 7-fold over the 5th to 10th percentile group.
“In a large retrospective cohort of more than 3 million singleton pregnancies, the risk of stillbirth at birthweights of less than the 3rd percentile was increased approximately 3-fold over the 3rd to 5th percentile group at nearly all gestational ages, and there was an increased risk of 4-fold to 7-fold over the 5th to 10th percentile group.63”
From Society for Maternal-Fetal Medicine Consult Series #52: Diagnosis and management of fetal growth restriction (2020) · cites this paper as [63]
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- Authors
- Pilliod, R. A., Cheng, Y. W., Snowden, J. M., Doss, A. E., & Caughey, A. B.
- Affiliations
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Corresponding author
- Pilliod, Rachel A.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 207
- Issue
- 4
- Pages
- 318.e1-318.e6
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3724359
- OpenAlex
- W2093640939
- Cited by
- 201
- References
- 25
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 17 · 2022: 18 · 2021: 23 · 2020: 21 · 2019: 12 · 2018: 16 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 10 · 2013: 9
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD01262, K12HD001262)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- intrauterine fetal death, small-for-gestational-age fetuses, birth weight for gestational age, fetal growth restriction, gestational age, birth weight percentiles
- MeSH terms
- Adult, Female, Fetal Death, Fetal Growth Retardation, Gestational Age, Humans, Maternal Age, Pregnancy, Retrospective Studies, Risk, Cohort Studies, Databases, Factual, Fetal Weight, Stillbirth
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